Search Results - "Chisholm, David"

Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes by Khatib, Thabat, Chisholm, David R, Whiting, Andrew, Platt, Bettina, McCaffery, Peter

“…Retinoic acid has been previously proposed in the treatment of Alzheimer's disease (AD). Here, five transgenic mouse models expressing AD and frontotemporal…”
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Conjugate Addition of 3‑Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring by Chisholm, David R, Valentine, Roy, Pohl, Ehmke, Whiting, Andrew

“…A convenient, mild and effective conjugate addition of 3-butyn-2-one to a variety of anilines in ethanol is reported. The reaction was monitored and…”
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Daniel Call’s Schocker: German Knittelvers in the late twentieth century by Chisholm, David

“…The word “Knittelvers” has been used since the eighteenth century to describe four-stress rhyming couplets which seem to be rather simply and awkwardly…”
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CYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity by Zolfaghari, Reza, Mattie, Floyd J., Wei, Cheng-Hsin, Chisholm, David R., Whiting, Andrew, Ross, A. Catharine

“…Of numerous genes regulated by retinoic acid (RA), CYP26A1 is the most inducible gene by RA. In this study, we have used a shortened construct form, E4, of the…”
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Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability by Hudhud, Lina, Chisholm, David R, Whiting, Andrew, Steib, Anita, Pohóczky, Krisztina, Kecskés, Angéla, Szőke, Éva, Helyes, Zsuzsanna

“…All-trans-retinoic acid (ATRA), the active metabolite of vitamin A, plays a pivotal role in cell differentiation, proliferation and embryonic development. It…”
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Detection and time-tracking activation of a photosensitiser on live single colorectal cancer cells using Raman spectroscopy by Gala de Pablo, Julia, Chisholm, David R, Ambler, Carrie A, Peyman, Sally A, Whiting, Andrew, Evans, Stephen D

“…Raman spectroscopy has been used to observe uptake, metabolism and response of single-cells to drugs. Photodynamic therapy is based on the use of light, a…”
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The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors by Haffez, Hesham, Chisholm, David R, Valentine, Roy, Pohl, Ehmke, Redfern, Christopher, Whiting, Andrew

“…All- -retinoic acid (ATRA) and its synthetic analogues EC23 and EC19 direct cellular differentiation by interacting as ligands for the retinoic acid receptor…”
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Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids by Haffez, Hesham, Chisholm, David R., Tatum, Natalie J., Valentine, Roy, Redfern, Christopher, Pohl, Ehmke, Whiting, Andrew, Przyborski, Stefan

“…[Display omitted] Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to…”
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A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor by Khatib, Thabat, Whiting, Andrew, Chisholm, David R., Redfern, Christopher, Müller, Berndt, McCaffery, Peter

“…Retinoic acid (RA) regulates numerous aspects of central nervous system function through modulation of gene transcription via retinoic acid receptors (RARs)…”
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The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria by Waite, Ryan, Adams, Candace T., Chisholm, David R., Sims, C. H. Cole, Hughes, Joshua G., Dias, Eva, White, Emily A., Welsby, Kathryn, Botchway, Stanley W., Whiting, Andrew, Sharples, Gary J., Ambler, Carrie A.

“…The emergence of antibiotic resistance is a growing threat to human health, and therefore, alternatives to existing compounds are urgently needed. In this…”
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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene by Chisholm, David R, Lamb, Rebecca, Pallett, Tommy, Affleck, Valerie, Holden, Claire, Marrison, Joanne, O'Toole, Peter, Ashton, Peter D, Newling, Katherine, Steffen, Andreas, Nelson, Amanda K, Mahler, Christoph, Valentine, Roy, Blacker, Thomas S, Bain, Angus J, Girkin, John, Marder, Todd B, Whiting, Andrew, Ambler, Carrie A

“…Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of…”
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Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids by Khatib, Thabat, Marini, Pietro, Nunna, Sudheer, Chisholm, David R, Whiting, Andrew, Redfern, Christopher, Greig, Iain R, McCaffery, Peter

“…Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In…”
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Cellular localisation of structurally diverse diphenylacetylene fluorophores by Chisholm, David R, Hughes, Joshua G, Blacker, Thomas S, Humann, Rachel, Adams, Candace, Callaghan, Daniel, Pujol, Alba, Lembicz, Nicola K, Bain, Angus J, Girkin, John M, Ambler, Carrie A, Whiting, Andrew

“…Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be…”
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Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480 by Gala de Pablo, Julia, Chisholm, David R, Steffen, Andreas, Nelson, Amanda K, Mahler, Christoph, Marder, Todd B, Peyman, Sally A, Girkin, John M, Ambler, Carrie A, Whiting, Andrew, Evans, Stephen D

“…The development of new imaging tools, molecules and modalities is crucial to understanding biological processes and the localised cellular impact of bioactive…”
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Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device by Sangeetha Menon, Amarnath, Subasic de Azevedo, Igor, Choong, Kylie, Bhatnagar, Dhruv, Wang, Chen, Sluka, Pavel, Chisholm, David R., Pasic, Paul, Thissen, Helmut, Sama, Gopal, Robinson, Andrea, Rodda, Andrew, Tria, Aldous, Spiegel, Loren, Dharma, Anak, Kaipananickal, Harikrishnan, Okabe, Jun, El-Osta, Assam, Mountford, Simon, Thompson, Philip, Dear, Anthony E.

“…Purpose The Lumi-Solve photo-angioplasty drug eluting balloon catheter (DEBc) may afford safety advantages over current DEBc. Lumi-Solve utilises the guidewire…”
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Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways by Chisholm, David R, Tomlinson, Charles W. E, Zhou, Garr-Layy, Holden, Claire, Affleck, Valerie, Lamb, Rebecca, Newling, Katherine, Ashton, Peter, Valentine, Roy, Redfern, Christopher, Erostyák, János, Makkai, Geza, Ambler, Carrie A, Whiting, Andrew, Pohl, Ehmke

“…Retinoids, such as all-trans-retinoic acid (ATRA), are endogenous signaling molecules derived from vitamin A that influence a variety of cellular processes…”
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Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins by Tomlinson, Charles W. E, Chisholm, David R, Valentine, Roy, Whiting, Andrew, Pohl, Ehmke

“…Vitamin A derived retinoid compounds have multiple, powerful roles in the cellular growth and development cycle and, as a result, have attracted significant…”
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Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines by Chisholm, David R, Zhou, Garr-Layy, Pohl, Ehmke, Valentine, Roy, Whiting, Andrew

“…The synthesis of novel tetrahydroquinolines (THQ) and dihydroquinolines (DHQ) are reported using three practical, scalable synthetic approaches to access…”
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SEDRFuse: A Symmetric Encoder-Decoder With Residual Block Network for Infrared and Visible Image Fusion by Jian, Lihua, Yang, Xiaomin, Liu, Zheng, Jeon, Gwanggil, Gao, Mingliang, Chisholm, David

“…Image fusion is an important task for computer vision as a diverse range of applications are benefiting from the fusion operation. The existing image fusion…”
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Position dependent ventricular tachycardia in two children with peripherally inserted central catheters (PICCs) by Hacking, Matthew B., Brown, Johanna, Chisholm, David G.

“…Summary We report two cases of ventricular tachycardia (VT) in children following the insertion of peripherally inserted central catheters (PICCs). These…”
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