Search Results - "Chiriac, Mircea T."

Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma by Krammer, Susanne, Sicorschi Gutu, Cristina, Grund, Janina C, Chiriac, Mircea T, Zirlik, Sabine, Finotto, Susetta

“…Asthma is a chronic respiratory disease affecting people of all ages, especially children, worldwide. Origins of asthma are suggested to be placed in early…”
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IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer by Heim, Lisanne, Yang, Zuqin, Tausche, Patrick, Hohenberger, Katja, Chiriac, Mircea T, Koelle, Julia, Geppert, Carol-Immanuel, Kachler, Katerina, Miksch, Sarah, Graser, Anna, Friedrich, Juliane, Kharwadkar, Rakshin, Rieker, Ralf J, Trufa, Denis I, Sirbu, Horia, Neurath, Markus F, Kaplan, Mark H, Finotto, Susetta

“…Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely…”
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Glucose-Restricted Diet Regulates the Tumor Immune Microenvironment and Prevents Tumor Growth in Lung Adenocarcinoma by Gähler, Alexander, Trufa, Denis I, Chiriac, Mircea T, Tausche, Patrick, Hohenberger, Katja, Brunst, Ann-Kathrin, Rauh, Manfred, Geppert, Carol I, Rieker, Ralf J, Krammer, Susanne, Leberle, Anna, Neurath, Markus F, Sirbu, Horia, Hartmann, Arndt, Finotto, Susetta

“…Lung cancer is the second common cancer type in western countries and has a high mortality. During the development and progression of the tumor, the nutrients…”
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Induction of Complement-Fixing Autoantibodies against Type VII Collagen Results in Subepidermal Blistering in Mice by Sitaru, Cassian, Chiriac, Mircea T, Mihai, Sidonia, Buning, Jurgen, Gebert, Andreas, Ishiko, Akira, Zillikens, Detlef

“…Experimental models reproducing an autoimmune response resulting in skin blistering in immunocompetent animals are lacking. Epidermolysis bullosa acquisita…”
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Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen by Sitaru, Cassian, Mihai, Sidonia, Otto, Christoph, Chiriac, Mircea T, Hausser, Ingrid, Dotterweich, Barbara, Saito, Hitoshi, Rose, Christian, Ishiko, Akira, Zillikens, Detlef

“…Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies specific to type VII…”
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An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease by Stolzer, Iris, Dressel, Anja, Chiriac, Mircea T., Neurath, Markus F., Günther, Claudia

“…Blocking interferon-function by therapeutic intervention of the JAK-STAT-axis is a novel promising treatment option for inflammatory bowel disease (IBD)…”
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Pathogenicity of IgG subclass autoantibodies to type VII collagen: Induction of dermal–epidermal separation by Recke, Andreas, Sitaru, Cassian, Vidarsson, Gestur, Evensen, Mirja, Chiriac, Mircea T, Ludwig, Ralf J, Zillikens, Detlef

“…Abstract In different autoimmune diseases, tissue damage is mediated by the Fc portion of autoantibodies. These include autoimmunity to type VII collagen, a…”
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IgG4 autoantibodies induce dermal–epidermal separation by Mihai, Sidonia, Chiriac, Mircea T., Herrero‐González, Josep E., Goodall, Margaret, Jefferis, Roy, Savage, Caroline O. S., Zillikens, Detlef, Sitaru, Cassian

“…Bullous pemphigoid (BP) is a sub‐epidermal autoimmune blistering disease associated with autoantibodies to the dermal–epidermal junction (DEJ). Patients’…”
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Targeting Immune Cell Wiring in Ulcerative Colitis by Neurath, Markus F., Chiriac, Mircea T.

“…The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of…”
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In vivo detection of mucosal healing-involved histiocytes by confocal laser endomicroscopy by Hundorfean, Gheorghe, Agaimy, Abbas, Chiriac, Mircea T, Geißdörfer, Walter, Wacker, Jochen, Neurath, Markus F, Mudter, Jonas

“…Histiocytes have a pivotal role in wound repair and intestinal epithelial recovery-the most important goal to sustain gut functionality.Yet,an in vivo…”
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STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs by Chiriac, Mircea T, Hracsko, Zsuzsanna, Becker, Christoph, Neurath, Markus F

“…Colorectal cancer (CRC) is a significant socioeconomic burden in modern society and is accountable for millions of premature deaths each year. The role of…”
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Development and Validation of a Confocal Laser Endomicroscopy-Based Score for In Vivo Assessment of Mucosal Healing in Ulcerative Colitis Patients by Hundorfean, Gheorghe, Chiriac, Mircea T, Mihai, Sidonia, Hartmann, Arndt, Mudter, Jonas, Neurath, Markus F

“…Abstract Background Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH)…”
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Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease by Chiriac, Mircea T, Buchen, Barbara, Wandersee, Alexandra, Hundorfean, Gheorghe, Günther, Claudia, Bourjau, Yvonne, Doyle, Sean E, Frey, Benjamin, Ekici, Arif B, Büttner, Christian, Weigmann, Benno, Atreya, Raja, Wirtz, Stefan, Becker, Christoph, Siebler, Jürgen, Neurath, Markus F

“…Background & Aims We investigated the roles of interleukin 28A (also called IL28A or interferon λ2) in intestinal epithelial cell (IEC) activation, studying…”
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TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma by Krug, Jasmin, Kiefer, Alexander, Koelle, Julia, Vuorinen, Tytti, Xepapadaki, Paraskevi, Stanic, Barbara, Chiriac, Mircea T, Akdis, Mübeccel, Zimmermann, Theodor, Papadopoulos, Nikolaos G, Finotto, Susetta

“…Interferon (IFN) responses have been reported to be defective in rhinovirus (RV)-induced asthma. The heterodimeric receptor of type I IFN (IFN-α/β) is composed…”
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Chitosan-coated triangular silver nanoparticles as a novel class of biocompatible, highly sensitive plasmonic platforms for intracellular SERS sensing and imaging by Potara, Monica, Boca, Sanda, Licarete, Emilia, Damert, Annette, Alupei, Marius-Costel, Chiriac, Mircea T, Popescu, Octavian, Schmidt, Ute, Astilean, Simion

“…There is a need for new strategies for noninvasive imaging of pathological conditions within the human body. The approach of combining the unique physical…”
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STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8 by Stolzer, Iris, Schickedanz, Laura, Chiriac, Mircea T., López-Posadas, Rocío, Grassl, Guntram A., Mattner, Jochen, Wirtz, Stefan, Winner, Beate, Neurath, Markus F., Günther, Claudia

“…Intestinal homeostasis and the maintenance of the intestinal epithelial barrier are essential components of host defense during gastrointestinal Salmonella…”
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Pemphigus vulgaris is the most common autoimmune bullous disease in Northwestern Romania by Baican, Adrian, Baican, Corina, Chiriac, Gabriela, Chiriac, Mircea T., Macovei, Victorina, Zillikens, Detlef, Ciuce, Dorina, Sitaru, Cassian

“…Background  Autoimmune bullous diseases are organ‐specific diseases characterized by autoreactive T and B cells specific for structural proteins of the skin…”
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STAT1 deficiency supports PD-1/PD-L1 signaling resulting in dysfunctional TNFα mediated immune responses in a model of NSCLC by Friedrich, Juliane, Heim, Lisanne, Trufa, Denis I, Sirbu, Horia, Rieker, Ralf J, Chiriac, Mircea T, Finotto, Susetta

“…In this study we described that Signal Transducer and Activator of Transcription 1 (STAT1) is a key point regulator of PD-1 in tumour infiltrating lymphocytes…”
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Su1699 Development and Initial Validation of a Diagnosis and Grading Score of Acute Gastrointestinal Graft-Versus-Host Disease by Probe-Based Confocal LASER Endomicroscopy (pCLE) by Hundorfean, Gheorghe, Chiriac, Mircea T, Agaimy, Abbas, Mackensen, Andreas, Siebler, Jürgen, Neurath, Markus F

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Confocal laser endomicroscopy provides potential differentiation criteria between Crohn's disease and ulcerative colitis by Hundorfean, Gheorghe, Chiriac, Mircea T, Mudter, Jonas, Neurath, Markus F

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