Search Results - "Chirgadze, D. Y."

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis by Wilson, L. F. L., Dendooven, T., Hardwick, S. W., Echevarría-Poza, A., Tryfona, T., Krogh, K. B. R. M., Chirgadze, D. Y., Luisi, B. F., Logan, D. T., Mani, K., Dupree, P.

“…Heparan sulfate is a highly modified O -linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially…”
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Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein–protein interactions by Núñez Miguel, R, Sanders, J, Chirgadze, D Y, Furmaniak, J, Rees Smith, B

“…The TSH receptor (TSHR) ligands M22 (a thyroid stimulating human monoclonal antibody) and TSH, bind to the concave surface of the leucine rich repeats domain…”
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FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity by Núñez Miguel, R, Sanders, J, Chirgadze, D Y, Blundell, T L, Furmaniak, J, Rees Smith, B

“…The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with…”
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Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function by Sanders, J, Jeffreys, J, Depraetere, H, Evans, M, Richards, T, Kiddie, A, Brereton, K, Premawardhana, L D K E, Chirgadze, D Y, Núñez Miguel, R, Blundell, T L, Furmaniak, J, Rees Smith, B

“…The properties of a human monoclonal antibody to the thyrotropin receptor (TSHR) (M22) with the characteristics of patient sera thyroid stimulating…”
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Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist by Sanders, J, Allen, F, Jeffreys, J, Bolton, J, Richards, T, Depraetere, H, Nakatake, N, Evans, M, Kiddie, A, Premawardhana, L D K E, Chirgadze, D Y, Miguel, R Núñez, Blundell, T L, Furmaniak, J, Smith, B Rees

“…Analysis of nine mouse monoclonal antibodies (mAbs) to the thyrotropin receptor (TSHR) with TSH antagonist activity showed that only one of the mAbs (RSR B2)…”
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Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate by Kerbarh, Olivier, Chirgadze, Dimitri Y., Blundell, Tom L., Abell, Chris

“…The salicylate synthase, Irp9, from Yersinia enterocolitica is involved in the biosynthesis of the siderophore yersiniabactin. It is a bifunctional enzyme that…”
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Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor by Lietha, Daniel, Chirgadze, Dimitri Y., Mulloy, Barbara, Blundell, Tom L., Gherardi, Ermanno

“…NK1 is a splice variant of the polypeptide growth factor HGF/SF, which consists of the N‐terminal (N) and first kringle (K) domain and requires heparan sulfate…”
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Structure of an Xrcc4–DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode by Doré, Andrew S., Furnham, Nicholas, Davies, Owen R., Sibanda, Bancinyane L., Chirgadze, Dimitri Y., Jackson, Stephen P., Pellegrini, Luca, Blundell, Tom L.

“…DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the…”
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Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding by Chirgadze, Dimitri Y, Demydchuk, Mykhaylo, Becker, Marion, Moran, Stephen, Paoli, Massimo

“…Protein-protein interactions govern a wide range of cellular processes. Molecular recognition responsible for homodimerization and heterodimerization in the…”
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Structural basis for collagen recognition by the immune receptor OSCAR by Zhou, Long, Hinerman, Jennifer M., Blaszczyk, Michal, Miller, Jeanette L.C., Conrady, Deborah G., Barrow, Alexander D., Chirgadze, Dimitri Y., Bihan, Dominique, Farndale, Richard W., Herr, Andrew B.

“…The osteoclast-associated receptor (OSCAR) is a collagen-binding immune receptor with important roles in dendritic cell maturation and activation of…”
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Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding by Gherardi, Ermanno, Chirgadze, Dimitri Y, Hepple, Jonathan P, Zhou, Hongjun, Byrd, R. Andrew, Blundell, Tom L

“…Although ligand-induced receptor dimerization is a common prerequisite for receptor activation, the mode by which different growth factors bind their receptors…”
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Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation by Chirgadze, Dimitri Y, Hepple, Jonathan, Byrd, R.Andrew, Sowdhamini, R, Blundell, Tom L, Gherardi, Ermanno

“…The modular structure of HGF/SF offers a reductionist or `divide and rule' approach to the analysis of structure and function. Domain deletion experiments have…”
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A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation by De Genst, Erwin, Chan, Pak-Ho, Pardon, Els, Hsu, Shang-Te D, Kumita, Janet R, Christodoulou, John, Menzer, Linda, Chirgadze, Dimitri Y, Robinson, Carol V, Muyldermans, Serge, Matagne, André, Wyns, Lode, Dobson, Christopher M, Dumoulin, Mireille

“…We report the effects of the interaction of two camelid antibody fragments, generally called nanobodies, namely cAb-HuL5 and a stabilized and more…”
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High-resolution crystal structure of the human Notch 1 ankyrin domain by Ehebauer, Matthias T, Chirgadze, Dimitri Y, Hayward, Penny, Martinez Arias, Alfonso, Blundell, Tom L

“…The Notch receptor is part of a highly conserved signalling system of central importance to animal development. Its ANK (ankyrin) domain is required for…”
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Crystal structure of the β‐chain of human hepatocyte growth factor‐like/macrophage stimulating protein by Carafoli, Federico, Chirgadze, Dimitri Y., Blundell, Tom L., Gherardi, Ermanno

“…Hepatocyte growth factor like/macrophage stimulating protein (HGFl/MSP) and hepatocyte growth factor/scatter factor (HGF/SF) define a distinct family of…”
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Structural constraints on protein self-processing in L-aspartate-α-decarboxylase by Schmitzberger, Florian, Kilkenny, Mairi L., Lobley, Carina M. C., Webb, Michael E., Vinkovic, Mladen, Matak-Vinkovic, Dijana, Witty, Michael, Chirgadze, Dimitri Y., Smith, Alison G., Abell, Chris, Blundell, Tom L.

“…Aspartate decarboxylase, which is translated as a pro‐protein, undergoes intramolecular self‐cleavage at Gly24–Ser25. We have determined the crystal structures…”
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Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1) by Owen, Darerca, Lowe, Peter N., Nietlispach, Daniel, Brosnan, C. Elaine, Chirgadze, Dimitri Y., Parker, Peter J., Blundell, Tom L., Mott, Helen R.

“…PRK1 is a serine/threonine kinase that belongs to the protein kinase C superfamily. It can be activated either by members of the Rho family of small G…”
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Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor by Lietha, D., Chirgadze, D. Y., Mulloy, M., Blundell, T. L., Gherardi, E.

“…Abstract only…”
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A New Crystal Form of the NK1 Splice Variant of HGF/SF Demonstrates Extensive Hinge Movement and Suggests That the NK1 Dimer Originates by Domain Swapping by Watanabe, Keiichi, Chirgadze, Dimitri Y., Lietha, Daniel, de Jonge, Hugo, Blundell, Tom L., Gherardi, Ermanno

“…NK1 is a splice variant of the polypeptide growth factor HGF/SF that consists of the N terminal (N) and first kringle (K) domains and retains receptor binding…”
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