Search Results - "Chirdo, Fernando G"

Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder by Dunne, Margaret R, Byrne, Greg, Chirdo, Fernando G, Feighery, Conleth

“…Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great…”
Get full text

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2 by Caminero, Alberto, McCarville, Justin L., Galipeau, Heather J., Deraison, Celine, Bernier, Steve P., Constante, Marco, Rolland, Corinne, Meisel, Marlies, Murray, Joseph A., Yu, Xuechen B., Alaedini, Armin, Coombes, Brian K., Bercik, Premysl, Southward, Carolyn M., Ruf, Wolfram, Jabri, Bana, Chirdo, Fernando G., Casqueiro, Javier, Surette, Michael G., Vergnolle, Nathalie, Verdu, Elena F.

“…Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a…”
Get full text

IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease by Perez, Federico, Ruera, Carolina N, Miculan, Emanuel, Carasi, Paula, Dubois-Camacho, Karen, Garbi, Laura, Guzman, Luciana, Hermoso, Marcela A, Chirdo, Fernando G

“…Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While…”
Get full text

Role of CXCR3/CXCL10 axis in immune cell recruitment into the small intestine in celiac disease by Bondar, Constanza, Araya, Romina E, Guzman, Luciana, Rua, Eduardo Cueto, Chopita, Nestor, Chirdo, Fernando G

“…Lymphocytic infiltration in the lamina propria (LP), which is primarily composed of CD4(+) Th1 cells and plasma cells, and increased numbers of intraepithelial…”
Get full text

Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease by Allegretti, Yessica L, Bondar, Constanza, Guzman, Luciana, Cueto Rua, Eduardo, Chopita, Nestor, Fuertes, Mercedes, Zwirner, Norberto W, Chirdo, Fernando G

“…The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen presentation. MICA/B…”
Get full text

Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen by Araya, Romina E, Jury, Jennifer, Bondar, Constanza, Verdu, Elena F, Chirdo, Fernando G

“…Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine…”
Get full text

Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice by Galipeau, Heather J, Rulli, Nestor E, Jury, Jennifer, Huang, Xianxi, Araya, Romina, Murray, Joseph A, David, Chella S, Chirdo, Fernando G, McCoy, Kathy D, Verdu, Elena F

“…Celiac disease (CD) is frequently diagnosed in patients with type 1 diabetes (T1D), and T1D patients can exhibit Abs against tissue transglutaminase, the…”
Get full text

Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy by Chirdo, Fernando G., Chopita, Nestor, Redondo, Agustina, Guzman, Luciana, Bondar, Constanza, García, Marina, Bottasso Arias, Natalia M., Córsico, Betina

“…Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes…”
Get full text

Statement of the Prolamin Working Group on the Determination of Gluten in Fermented Foods Containing Partially Hydrolyzed Gluten by Scherf, Katharina Anne, Catassi, Carlo, Chirdo, Fernando G, Ciclitira, Paul J, Feighery, Conleth Francis, Gianfrani, Carmen, Koning, Frits, Lundin, Knut E A, Masci, Stefania, Schuppan, Detlef, Smulders, Marinus J M, Tranquet, Olivier, Troncone, Riccardo, Koehler, Peter

Get full text

Immunomodulatory dendritic cells in intestinal lamina propria by Chirdo, Fernando G., Millington, Owain R., Beacock-Sharp, Helen, Mowat, Allan McI

Get full text

Increased Intraepithelial Vα24 Invariant NKT Cells in the Celiac Duodenum by Montalvillo, Enrique, Bernardo, David, Martínez-Abad, Beatriz, Allegretti, Yessica, Fernández-Salazar, Luis, Calvo, Carmen, Chirdo, Fernando G, Garrote, José A, Arranz, Eduardo

“…Celiac Disease (CD) is an interferon (IFN)γ-mediated duodenal hypersensitivity to wheat gluten occurring in genetically predisposed individuals. Gluten-free…”
Get full text

Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease by Ruera, Carolina N, Perez, Federico, Iribarren, María Luz, Guzman, Luciana, Menendez, Lorena, Garbi, Laura, Chirdo, Fernando G

“…Usually, the massive elimination of cells under steady-state conditions occurs by apoptosis, which is also acknowledged to explain the loss of enterocytes in…”
Get full text

Biogeographic Variation and Functional Pathways of the Gut Microbiota in Celiac Disease by Constante, Marco, Libertucci, Josie, Galipeau, Heather J., Szamosi, Jake C., Rueda, Gaston, Miranda, Pedro M., Pinto-Sanchez, Maria Ines, Southward, Carolyn M., Rossi, Laura, Fontes, Michelle E., Chirdo, Fernando G., Surette, Michael G., Bercik, Premysl, Caminero, Alberto, Verdu, Elena F.

“…Genes and gluten are necessary but insufficient to cause celiac disease (CeD). Altered gut microbiota has been implicated as an additional risk factor…”
Get full text

Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice by Galipeau, Heather J, McCarville, Justin L, Huebener, Sina, Litwin, Owen, Meisel, Marlies, Jabri, Bana, Sanz, Yolanda, Murray, Joseph A, Jordana, Manel, Alaedini, Armin, Chirdo, Fernando G, Verdu, Elena F

“…Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. The recent increase in CD incidence suggests…”
Get full text

Sterile inflammation drives multiple programmed cell death pathways in the gut by Ruera, Carolina N., Miculán, Emanuel, Pérez, Federico, Ducca, Gerónimo, Carasi, Paula, Chirdo, Fernando G.

“…Intestinal epithelial cells have a rapid turnover, being rapidly renewed by newly differentiated enterocytes, balanced by massive and constant removal of…”
Get full text

Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium by Rahmani, Sara, Galipeau, Heather J., Clarizio, Alexandra V., Wang, Xuanyu, Hann, Amber, Rueda, Gaston H., Kirtikar, Utkarshini N., Constante, Marco, Wulczynski, Mark, Su, Hsuan-Ming, Burchett, Rebecca, Bramson, Jonathan L., Pinto-Sanchez, Maria Ines, Stefanolo, Juan Pablo, Niveloni, Sonia, Surette, Michael G., Murray, Joseph A., Anderson, Robert P., Bercik, Premysl, Caminero, Alberto, Chirdo, Fernando G., F. Didar, Tohid, Verdu, Elena F.

“…Intestinal epithelial cell (IEC) damage is a hallmark of celiac disease (CeD); however, its role in gluten-dependent T-cell activation is unknown. We…”
Get full text

Mechanisms of innate immune activation by gluten peptide p31-43 in mice by Araya, Romina E, Gomez Castro, María Florencia, Carasi, Paula, McCarville, Justin L, Jury, Jennifer, Mowat, Allan M, Verdu, Elena F, Chirdo, Fernando G

“…Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Innate immunity contributes to the…”
Get more information

Immunomodulatory dendritic cells in intestinal lamina propria by Chirdo, Fernando G., Millington, Owain R., Beacock‐Sharp, Helen, Mowat, Allan McI

“…The lamina propria (LP) of the small intestine contains many dendritic cells (DC), which are likely to be in close contact with luminal antigens, but their…”
Get full text

Single Domain Antibodies Are Specially Suited for Quantitative Determination of Gliadins under Denaturing Conditions by Doña, Vanina, Urrutia, Mariela, Bayardo, Mariela, Alzogaray, Vanina, Goldbaum, Fernando Alberto, Chirdo, Fernando G

“…Food intended for celiac patients' consumption must be analyzed for the presence of toxic prolamins using high detectability tests. Though 60% ethanol is the…”
Get full text

Production of the Main Celiac Disease Autoantigen by Transient Expression in Nicotiana benthamiana by Marín Viegas, Vanesa S, Acevedo, Gonzalo R, Bayardo, Mariela P, Chirdo, Fernando G, Petruccelli, Silvana

“…Celiac Disease (CD) is a gluten sensitive enteropathy that remains widely undiagnosed and implementation of massive screening tests is needed to reduce the…”
Get full text