Search Results - "Chiramel, Abhilash I."

Role of autophagy in Zika virus infection and pathogenesis by Chiramel, Abhilash I., Best, Sonja M.

“…•Autophagy is pro- and antiviral in ZIKV infection.•ZIKV evades ER-Phagy by cleaving autophagy receptor FAM134B.•Autophagy is a critical antiviral response at…”
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FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga by Chiramel, Abhilash I., Dougherty, Jonathan D., Nair, Vinod, Robertson, Shelly J., Best, Sonja M.

“…Selective autophagy of the endoplasmic reticulum (termed ER-phagy) is controlled by members of the FAMI34 reticulon protein family. Here we used mouse…”
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miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells by KOVALEVA, Valentina, MORA, Rodrigo, SEIFFERT, Martina, YOON JUNG PARK, PLASS, Christoph, CHIRAMEL, Abhilash I, BARTENSCHLAGER, Ralf, DÖHNER, Hartmut, STILGENBAUER, Stephan, PSCHERER, Armin, LICHTER, Peter

“…Toxicity and relapses from the immunochemotherapy used to treat chronic lymphocytic leukemia (CLL) prompt continued interest in gentle but effective targeted…”
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Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2 by Shi, Guoli, Chiramel, Abhilash I, Li, Tiansheng, Lai, Kin Kui, Kenney, Adam D, Zani, Ashley, Eddy, Adrian C, Majdoul, Saliha, Zhang, Lizhi, Dempsey, Tirhas, Beare, Paul A, Kar, Swagata, Yewdell, Jonathan W, Best, Sonja M, Yount, Jacob S, Compton, Alex A

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and…”
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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation by Chiramel, Abhilash I, Meyerson, Nicholas R, McNally, Kristin L, Broeckel, Rebecca M, Montoya, Vanessa R, Méndez-Solís, Omayra, Robertson, Shelly J, Sturdevant, Gail L, Lubick, Kirk J, Nair, Vinod, Youseff, Brian H, Ireland, Robin M, Bosio, Catharine M, Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M, Taylor, R Travis, Bouamr, Fadila, Sawyer, Sara L, Best, Sonja M

“…Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity…”
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Disruption of the Golgi Apparatus and Contribution of the Endoplasmic Reticulum to the SARS-CoV-2 Replication Complex by Hackstadt, Ted, Chiramel, Abhilash I., Hoyt, Forrest H., Williamson, Brandi N., Dooley, Cheryl A., Beare, Paul A., de Wit, Emmie, Best, Sonja M., Fischer, Elizabeth R.

“…A variety of immunolabeling procedures for both light and electron microscopy were used to examine the cellular origins of the host membranes supporting the…”
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AP3B1 Has Type I Interferon-Independent Antiviral Function against SARS-CoV-2 by Subramanian, Gayatri, Hage, Adam, Feldmann, Friederike, Chiramel, Abhilash I, McNally, Kristin L, Sturdevant, Gail L, Beare, Paul A, Best, Sonja M

“…The unprecedented research effort associated with the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) included several extensive…”
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A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis by Broeckel, Rebecca M, Feldmann, Friederike, McNally, Kristin L, Chiramel, Abhilash I, Sturdevant, Gail L, Leung, Jacqueline M, Hanley, Patrick W, Lovaglio, Jamie, Rosenke, Rebecca, Scott, Dana P, Saturday, Greg, Bouamr, Fadila, Rasmussen, Angela L, Robertson, Shelly J, Best, Sonja M

“…Kyasanur Forest disease virus (KFDV) and the closely related Alkhurma hemorrhagic disease virus (AHFV) are emerging flaviviruses that cause severe viral…”
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Divergent roles of autophagy in virus infection by Chiramel, Abhilash I, Brady, Nathan R, Bartenschlager, Ralf

“…Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens,…”
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A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle by Martin, Scott, Chiramel, Abhilash I, Schmidt, Marie Luisa, Chen, Yu-Chi, Whitt, Nadia, Watt, Ari, Dunham, Eric C, Shifflett, Kyle, Traeger, Shelby, Leske, Anne, Buehler, Eugen, Martellaro, Cynthia, Brandt, Janine, Wendt, Lisa, Müller, Andreas, Peitsch, Stephanie, Best, Sonja M, Stech, Jürgen, Finke, Stefan, Römer-Oberdörfer, Angela, Groseth, Allison, Feldmann, Heinz, Hoenen, Thomas

“…The 2014-2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host…”
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Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM by Basu, Rajeswari, Dambra, Richard, Jiang, Di, Schätzlein, Sophia A, Njiyang, Shu, Ashour, Joseph, Chiramel, Abhilash I, Vigil, Adam, Papov, Jr, Vladimir V

“…The rapidly developing field of oncolytic virus (OV) therapy necessitates the development of new and improved analytical approaches for the characterization of…”
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Unique Francisella Phosphatidylethanolamine Acts as a Potent Anti-Inflammatory Lipid by Ireland, Robin, Schwarz, Benjamin, Nardone, Glenn, Wehrly, Tara D., Broeckling, Corey D., Chiramel, Abhilash I., Best, Sonja M., Bosio, Catharine M.

“…Virulent Francisella tularensis subsp. tularensis (Ftt) is a dynamic, intracellular, bacterial pathogen. Its ability to evade and rapidly suppress host…”
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Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses by Dunham, Eric C., Banadyga, Logan, Groseth, Allison, Chiramel, Abhilash I., Best, Sonja M., Ebihara, Hideki, Feldmann, Heinz, Hoenen, Thomas

“…The current Ebola virus (EBOV) outbreak in West Africa is unprecedented in terms of both its size and duration, and there has been speculation and concern…”
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A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection by Dutta, Mukta, Robertson, Shelly J., Okumura, Atsushi, Scott, Dana P., Chang, Jean, Weiss, Jeffrey M., Sturdevant, Gail L., Feldmann, Friederike, Haddock, Elaine, Chiramel, Abhilash I., Ponia, Sanket S., Dougherty, Jonathan D., Katze, Michael G., Rasmussen, Angela L., Best, Sonja M.

“…The unprecedented 2013–2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor…”
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The liver X receptor agonist LXR 623 restricts flavivirus replication by Mlera, Luwanika, Offerdahl, Danielle K., Dorward, David W., Carmody, Aaron, Chiramel, Abhilash I., Best, Sonja M., Bloom, Marshall E.

“…The vector-borne flaviviruses (VBFVs) are well known for causing great misery and death in humans worldwide. The VBFVs include those transmitted by mosquitos,…”
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Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression by Lubick, Kirk J., Robertson, Shelly J., McNally, Kristin L., Freedman, Brett A., Rasmussen, Angela L., Taylor, R. Travis, Walts, Avram D., Tsuruda, Seitaro, Sakai, Mizuki, Ishizuka, Mariko, Boer, Elena F., Foster, Erin C., Chiramel, Abhilash I., Addison, Conrad B., Green, Richard, Kastner, Daniel L., Katze, Michael G., Holland, Steven M., Forlino, Antonella, Freeman, Alexandra F., Boehm, Manfred, Yoshii, Kentaro, Best, Sonja M.

“…Type I interferon (IFN-α/β or IFN-I) signals through two receptor subunits, IFNAR1 and IFNAR2, to orchestrate sterile and infectious immunity. Cellular…”
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Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection by Tran, Pham-Tue-Hung, Chiramel, Abhilash I, Johansson, Magnus, Melik, Wessam

“…Flaviviruses are usually transmitted to humans via mosquito or tick bites. During infection, virus replication and assembly, whose cellular sites are…”
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Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication by Shue, Byron, Chiramel, Abhilash I, Cerikan, Berati, To, Thu-Hien, Frölich, Sonja, Pederson, Stephen M, Kirby, Emily N, Eyre, Nicholas S, Bartenschlager, Ralf F W, Best, Sonja M, Beard, Michael R

“…Cellular factors have important roles in all facets of the flavivirus replication cycle. Deciphering viral-host protein interactions is essential for…”
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Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19 by Robertson, Shelly J., Bedard, Olivia, McNally, Kristin L., Shaia, Carl, Clancy, Chad S., Lewis, Matthew, Broeckel, Rebecca M., Chiramel, Abhilash I., Shannon, Jeffrey G., Sturdevant, Gail L., Rosenke, Rebecca, Anzick, Sarah L., Forte, Elvira, Preuss, Christoph, Baker, Candice N., Harder, Jeffrey M., Brunton, Catherine, Munger, Steven, Bruno, Daniel P., Lack, Justin B., Leung, Jacqueline M., Shamsaddini, Amirhossein, Gardina, Paul, Sturdevant, Daniel E., Sun, Jian, Martens, Craig, Holland, Steven M., Rosenthal, Nadia A., Best, Sonja M.

“…Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and…”
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Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga by Chiramel, Abhilash I., Banadyga, Logan, Dougherty, Jonathan D., Falzarano, Darryl, Martellaro, Cynthia, Brees, Dominique, Taylor, R. Travis, Ebihara, Hideki, Best, Sonja M.

“…Antiviral therapeutics with existing clinical safely profiles would be highly desirable in an outbreak situation, such as the 2013-2016 emergence of Ebola…”
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