Search Results - "Chipuk, Jerry E"

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? by Chipuk, Jerry E, Green, Douglas R

“…The mitochondrial pathway of apoptosis proceeds when molecules sequestered between the outer and inner mitochondrial membranes are released to the cytosol by…”
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Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors by Serasinghe, Madhavika N., Wieder, Shira Y., Renault, Thibaud T., Elkholi, Rana, Asciolla, James J., Yao, Jonathon L., Jabado, Omar, Hoehn, Kyle, Kageyama, Yusuke, Sesaki, Hiromi, Chipuk, Jerry E.

“…Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic role in cancer biology remains unknown. Here, we examine the direct…”
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Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis by Chipuk, Jerry E., McStay, Gavin P., Bharti, Archana, Kuwana, Tomomi, Clarke, Christopher J., Siskind, Leah J., Obeid, Lina M., Green, Douglas R.

“…Mitochondria are functionally and physically associated with heterotypic membranes, yet little is known about how these interactions impact mitochondrial…”
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GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells by Greter, Melanie, Helft, Julie, Chow, Andrew, Hashimoto, Daigo, Mortha, Arthur, Agudo-Cantero, Judith, Bogunovic, Milena, Gautier, Emmanuel L., Miller, Jennifer, Leboeuf, Marylene, Lu, Geming, Aloman, Costica, Brown, Brian D., Pollard, Jeffrey W., Xiong, Huabao, Randolph, Gwendalyn J., Chipuk, Jerry E., Frenette, Paul S., Merad, Miriam

“…GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and…”
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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool by Jordan, Stefan, Tung, Navpreet, Casanova-Acebes, Maria, Chang, Christie, Cantoni, Claudia, Zhang, Dachuan, Wirtz, Theresa H., Naik, Shruti, Rose, Samuel A., Brocker, Chad N., Gainullina, Anastasiia, Hornburg, Daniel, Horng, Sam, Maier, Barbara B., Cravedi, Paolo, LeRoith, Derek, Gonzalez, Frank J., Meissner, Felix, Ochando, Jordi, Rahman, Adeeb, Chipuk, Jerry E., Artyomov, Maxim N., Frenette, Paul S., Piccio, Laura, Berres, Marie-Luise, Gallagher, Emily J., Merad, Miriam

“…Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation…”
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Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis by Renault, Thibaud T., Floros, Konstantinos V., Elkholi, Rana, Corrigan, Kelly-Ann, Kushnareva, Yulia, Wieder, Shira Y., Lindtner, Claudia, Serasinghe, Madhavika N., Asciolla, James J., Buettner, Christoph, Newmeyer, Donald D., Chipuk, Jerry E.

“…Proapoptotic BCL-2 proteins converge upon the outer mitochondrial membrane (OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis…”
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Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis by Follis, Ariele Viacava, Llambi, Fabien, Merritt, Parker, Chipuk, Jerry E., Green, Douglas R., Kriwacki, Richard W.

“…The cytosolic fraction of the tumor suppressor p53 activates the apoptotic effector protein BAX to trigger apoptosis. Here we report that p53 activates BAX…”
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Mitochondrial origins of fractional control in regulated cell death by Santos, Luís C., Vogel, Robert, Chipuk, Jerry E., Birtwistle, Marc R., Stolovitzky, Gustavo, Meyer, Pablo

“…Individual cells in clonal populations often respond differently to environmental changes; for binary phenotypes, such as cell death, this can be measured as a…”
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Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization by Cassidy-Stone, Ann, Chipuk, Jerry E., Ingerman, Elena, Song, Cheng, Yoo, Choong, Kuwana, Tomomi, Kurth, Mark J., Shaw, Jared T., Hinshaw, Jenny E., Green, Douglas R., Nunnari, Jodi

“…Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release…”
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Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition by Trotta, Andrew P., Gelles, Jesse D., Serasinghe, Madhavika N., Loi, Patrick, Arbiser, Jack L., Chipuk, Jerry E.

“…The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative…”
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PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes by Wickramasinghe, Nadeera M., Sachs, David, Shewale, Bhavana, Gonzalez, David M., Dhanan-Krishnan, Priyanka, Torre, Denis, LaMarca, Elizabeth, Raimo, Serena, Dariolli, Rafael, Serasinghe, Madhavika N., Mayourian, Joshua, Sebra, Robert, Beaumont, Kristin, Iyengar, Srinivas, French, Deborah L., Hansen, Arne, Eschenhagen, Thomas, Chipuk, Jerry E., Sobie, Eric A., Jacobs, Adam, Akbarian, Schahram, Ischiropoulos, Harry, Ma’ayan, Avi, Houten, Sander M., Costa, Kevin, Dubois, Nicole C.

“…Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease, but they are…”
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BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak by Du, Han, Wolf, Jacob, Schafer, Blanca, Moldoveanu, Tudor, Chipuk, Jerry E., Kuwana, Tomomi

“…Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the…”
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How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis by Elkholi, Rana, Chipuk, Jerry E.

“…Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome integrity, cancer development, and cancer treatment has intrigued…”
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma by Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John, Chipuk, Jerry E., Brody, Rachel, Itzkowitz, Steven, Chio, Iok In Christine, Hasson, Dan, Bernstein, Emily, Parsons, Ramon E.

“…Tumors exhibit enhancer reprogramming compared to normal tissue. The etiology is largely attributed to cell-intrinsic genomic alterations. Here, using freshly…”
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Do inducers of apoptosis trigger caspase-independent cell death? by Chipuk, Jerry E, Green, Douglas R

“…Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which…”
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BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly by Kuwana, Tomomi, Bouchier-Hayes, Lisa, Chipuk, Jerry E., Bonzon, Christine, Sullivan, Barbara A., Green, Douglas R., Newmeyer, Donald D.

“…Using a Bax-dependent membrane-permeabilization assay, we show that peptides corresponding to the BH3 domains of Bcl-2 family “BH3-only” proteins have dual…”
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PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis by Follis, Ariele Viacava, Chipuk, Jerry E, Fisher, John C, Yun, Mi-Kyung, Grace, Christy R, Nourse, Amanda, Baran, Katherine, Ou, Li, Min, Lie, White, Stephen W, Green, Douglas R, Kriwacki, Richard W

“…π-stacking interactions unique between residues of PUMA and Bcl-xL, which lead to the unfolding of Bcl-xL via an allosteric mechanism, are required to disrupt…”
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Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2 by LOPEZ-RIVERA, Esther, JAYARAMAN, Padmini, AGUIRRE-GHISO, Julio, SIKORA, Andrew G, PARIKH, Falguni, DAVIES, Michael A, EKMEKCIOGLU, Suhendan, IZADMEHR, Sudeh, MILTON, Denái R, CHIPUK, Jerry E, GRIMM, Elizabeth A, ESTRADA, Yeriel

“…Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide synthase (iNOS) is overexpressed in melanoma and other cancers,…”
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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins by Chipuk, Jerry E, Fisher, John C, Dillon, Christopher P, Kriwacki, Richard W, Kuwana, Tomomi, Green, Douglas R

“…Normal cellular lifespan is contingent upon preserving outer mitochondrial membrane (OMM) integrity, as permeabilization promotes apoptosis. BCL-2 family…”
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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis by Chipuk, Jerry E., Kuwana, Tomomi, Bouchier-Hayes, Lisa, Droin, Nathalie M., Newmeyer, Donald D., Schuler, Martin, Green, Douglas R.

“…The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that cytosolic localization of endogenous…”
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