Search Results - "Chiozzi, Paola"

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine by Chiozzi, Paola, Sarti, Alba Clara, Sanz, Juana M., Giuliani, Anna Lisa, Adinolfi, Elena, Vultaggio-Poma, Valentina, Falzoni, Simonetta, Di Virgilio, Francesco

“…Previous data from our laboratory show that expression of the P2X7 receptor (P2X7R) is needed for amyloid β (Aβ)-stimulated microglia activation and IL-1β…”
Get full text

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor by Adinolfi, Elena, Cirillo, Maria, Woltersdorf, Ronja, Falzoni, Simonetta, Chiozzi, Paola, Pellegatti, Patrizia, Callegari, Maria Giulia, Sandonà, Doriana, Markwardt, Fritz, Schmalzing, Günther, Di Virgilio, Francesco

“…P2X7 is the largest member of the P2X subfamily of purinergic receptors. A typical feature is the carboxyl tail, which allows formation of a large pore…”
Get full text

The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism by RAFFAGHELLO, Lizzia, CHIOZZI, Paola, FALZONI, Simonetta, DI VIRGILIO, Francesco, PISTOIA, Vito

“…P2X(7) is a receptor for extracellular nucleotides expressed by different normal cell types. P2X(7) triggering may result in stimulation of cell proliferation…”
Get full text

Nucleotide receptors: an emerging family of regulatory molecules in blood cells by Di Virgilio, Francesco, Chiozzi, Paola, Ferrari, Davide, Falzoni, Simonetta, Sanz, Juana M., Morelli, Anna, Torboli, Maurizia, Bolognesi, Giorgio, Baricordi, O. Roberto

“…Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has been known for many years that adenosine diphosphate is a potent…”
Get full text

Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7 ATP Receptor by Baricordi, O. Roberto, Melchiorri, Loredana, Adinolfi, Elena, Falzoni, Simonetta, Chiozzi, Paola, Buell, Gary, Di Virgilio, Francesco

“…Human leukocytes can express the P2X7 purinergic receptor, an ionic channel gated by extracellular ATP, for which the physiological role is only partially…”
Get full text

Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo by Roberto, M., Ferrari, Davide, Fogli, Miriam, Rossi, Lara, Pizzirani, Cinzia, Forchap, Sylvia, Chiozzi, Paola, Vaselli, Diletta, Bertolini, Francesco, Foutz, Thomas, Aluigi, Michela, Baccarani, Michele, Di Virgilio, Francesco

“…Although extracellular nucleotides support a wide range of biologic responses of mature blood cells, little is known about their effect on blood cell…”
Get full text

Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4 by Solini, Anna, Santini, Eleonora, Chimenti, Daniele, Chiozzi, Paola, Pratesi, Federico, Cuccato, Sabina, Falzoni, Simonetta, Lupi, Roberto, Ferrannini, Ele, Pugliese, Giuseppe, Di Virgilio, Francesco

“…Apoptosis, a normal event in renal tissue homeostasis, has been considered as a major mechanism for either resolution of glomerular hypercellularity in…”
Get more information

Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release by Solini, A, Chiozzi, P, Morelli, A, Fellin, R, Di Virgilio, F

“…We have investigated reponses to extracellular ATP in human fibroblasts obtained by skin biopsies. Our data show that these cells express a P2X7 purinergic…”
Get full text

The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release by Ferrari, Davide, La Sala, Andrea, Chiozzi, Paola, Morelli, Anna, Falzoni, Simonetta, Girolomoni, Giampiero, Idzko, Marco, Dichmann, Stefan, Norgauer, Johannes, Di Virgilio, Francesco

“…ABSTRACT We investigated the expression of purinoceptors in human dendritic cells, providing functional, pharmacological, and biochemical evidence that…”
Get full text

Mouse Dendritic Cells Express the P2X7 Purinergic Receptor: Characterization and Possible Participation in Antigen Presentation by Mutini, Carmela, Falzoni, Simonetta, Ferrari, Davide, Chiozzi, Paola, Morelli, Anna, Baricordi, O. Roberto, Collo, Ginetta, Ricciardi-Castagnoli, Paola, Di Virgilio, Francesco

“…Immune cells express P2 purinoceptors of the P2Y and P2X subtypes. In the present work, we show that three dendritic cell (DC) lines, D2SC/1, CB1, and FSDC,…”
Get full text

Spontaneous Cell Fusion in Macrophage Cultures Expressing High Levels of the P2Z/P2X7 Receptor by Chiozzi, Paola, Sanz, Juana M., Ferrari, Davide, Falzoni, Simonetta, Aleotti, Arrigo, Buell, Gary N., Collo, Ginetta, Di Virgilio, Francesco

“…Mouse and human macrophages express a plasma membrane receptor for extracellular ATP named P2Z/P2X7. This molecule, recently cloned, is endowed with the…”
Get full text

P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production by Ferrari, Davide, Idzko, Marco, Dichmann, Stefan, Purlis, Daniela, Virchow, Christian, Norgauer, Johannes, Chiozzi, Paola, Di Virgilio, Francesco, Luttmann, Werner

“…Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far…”
Get full text

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein by Franceschini, Alessia, Capece, Marina, Chiozzi, Paola, Falzoni, Simonetta, Sanz, Juana Maria, Sarti, Alba Clara, Bonora, Massimo, Pinton, Paolo, Di Virgilio, Francesco

“…ABSTRACT The P2X7 receptor (P2X7R) is a known and powerful activator of the NOD‐like receptor (NLR)P3 inflammasome; however, the underlying pathways are poorly…”
Get full text

Expression of P2X7 Receptor Increases In Vivo Tumor Growth by ADINOLFI, Elena, RAFFAGHELLO, Lizzia, GIULIANI, Anna Lisa, CAVAZZINI, Luigi, CAPECE, Marina, CHIOZZI, Paola, BIANCHI, Giovanna, KROEMER, Guido, PISTOIA, Vito, DI VIRGILIO, Francesco

“…The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, recent evidence suggests a role for P2X7 in cell proliferation. Here,…”
Get full text

Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression by Sanz, Juana M., Chiozzi, Paola, Ferrari, Davide, Colaianna, Marilena, Idzko, Marco, Falzoni, Simonetta, Fellin, Renato, Trabace, Luigia, Di Virgilio, Francesco

“…Extracellular ATP is a mediator of intercellular communication and a danger signal. Release of this and other nucleotides modulates microglia responses via P2Y…”
Get full text

Role of the Purinergic P2Z Receptor in Spontaneous Cell Death in J774 Macrophage Cultures by Chiozzi, Paola, Murgia, Marta, Falzoni, Simonetta, Ferrari, Davide, Di Virgilio, Francesco

“…J774 mouse macrophages express an ionotropic receptor gated by extracellular ATP. Activation of this receptor, currently named purinergic P2Z, causes…”
Get full text

Stimulation of P2 receptors causes release of IL-1β–loaded microvesicles from human dendritic cells by Pizzirani, Cinzia, Ferrari, Davide, Chiozzi, Paola, Adinolfi, Elena, Sandonà, Dorianna, Savaglio, Erika, Di Virgilio, Francesco

“…Dendritic cells (DCs) are professional antigen-presenting cells that initiate the immune response by activating T lymphocytes. DCs express plasma membrane…”
Get full text

Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation by Vultaggio-Poma, Valentina, Falzoni, Simonetta, Chiozzi, Paola, Sarti, Alba Clara, Adinolfi, Elena, Giuliani, Anna Lisa, Sánchez-Melgar, Alejandro, Boldrini, Paola, Zanoni, Michele, Tesei, Anna, Pinton, Paolo, Di Virgilio, Francesco

“…: Caloric restriction improves the efficacy of anti-cancer therapy. This effect is largely dependent on the increase of the extracellular ATP concentration in…”
Get full text

P2X7 targeting inhibits growth of human mesothelioma by Amoroso, Francesca, Salaro, Erica, Falzoni, Simonetta, Chiozzi, Paola, Giuliani, Anna Lisa, Cavallesco, Giorgio, Maniscalco, Pio, Puozzo, Andrea, Bononi, Ilaria, Martini, Fernanda, Tognon, Mauro, Di Virgilio, Francesco

“…Malignant pleural mesothelioma (MPM) is an aggressive tumor refractory to anti-blastic therapy. MPM cells show several genetic and biochemical defects, e.g…”
Get full text

Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells by Di Virgilio, Francesco, Jiang, Lin-Hua, Roger, Sébastien, Falzoni, Simonetta, Sarti, Alba Clara, Vultaggio-Poma, Valentina, Chiozzi, Paola, Adinolfi, Elena

“…The P2X7 receptor [P2X7R or P2RX7 in National Center for Biotechnology Information (NCBI) gene nomenclature] is a member of the P2X receptor (P2XR) subfamily…”
Get more information