Search Results - "Chioti, Vasiliki T."
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N–Cα Bond Cleavage Catalyzed by a Multinuclear Iron Oxygenase from a Divergent Methanobactin-like RiPP Gene Cluster
Published in Journal of the American Chemical Society (20-03-2024)“…DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes involved in the biosynthesis of ribosomally synthesized and…”
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Journal Article -
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Potent and specific antibiotic combination therapy against Clostridioides difficile
Published in Nature chemical biology (01-07-2024)“…Keratinicyclins and keratinimicins are recently discovered glycopeptide antibiotics. Keratinimicins show broad-spectrum activity against Gram-positive…”
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Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB
Published in ACS chemical biology (21-07-2023)“…The emergence of multidrug-resistant pathogens poses a threat to public health and requires new antimicrobial agents. As the archetypal glycopeptide antibiotic…”
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Studying protein‐protein interactions in fatty acid and polyketide biosynthetic pathways via site‐specific vibrational spectroscopy
Published in The FASEB journal (01-04-2018)“…By virtue of their structural diversity and striking potency, natural products have long been used as therapeutic agents. Natural products are biosynthesized…”
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