Search Results - "Chiorazzi, N"

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia by Chen, S-S, Chang, B Y, Chang, S, Tong, T, Ham, S, Sherry, B, Burger, J A, Rai, K R, Chiorazzi, N

“…Bruton’s tyrosine kinase (BTK) is involved in the regulation of B-cell growth, migration and adhesion. The importance of BTK in cell trafficking is emphasized…”
Get full text

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation by Ghia, P., Chiorazzi, N., Stamatopoulos, K.

“… Several studies suggest that immune‐mediated pathways are important in the pathogenesis of chronic lymphocytic leukaemia (CLL). The in vivo accumulation of…”
Get full text

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia by Young, E, Noerenberg, D, Mansouri, L, Ljungström, V, Frick, M, Sutton, L-A, Blakemore, S J, Galan-Sousa, J, Plevova, K, Baliakas, P, Rossi, D, Clifford, R, Roos-Weil, D, Navrkalova, V, Dörken, B, Schmitt, C A, Smedby, K E, Juliusson, G, Giacopelli, B, Blachly, J S, Belessi, C, Panagiotidis, P, Chiorazzi, N, Davi, F, Langerak, A W, Oscier, D, Schuh, A, Gaidano, G, Ghia, P, Xu, W, Fan, L, Bernard, O A, Nguyen-Khac, F, Rassenti, L, Li, J, Kipps, T J, Stamatopoulos, K, Pospisilova, S, Zenz, T, Oakes, C C, Strefford, J C, Rosenquist, R, Damm, F

“…Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To…”
Get full text

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood by Herndon, T M, Chen, S-S, Saba, N S, Valdez, J, Emson, C, Gatmaitan, M, Tian, X, Hughes, T E, Sun, C, Arthur, D C, Stetler-Stevenson, M, Yuan, C M, Niemann, C U, Marti, G E, Aue, G, Soto, S, Farooqui, M Z H, Herman, S E M, Chiorazzi, N, Wiestner, A

“…Chronic lymphocytic leukemia (CLL) is a progressive malignancy of mature B-cells that involves the peripheral blood (PB), lymph nodes (LNs) and bone marrow…”
Get full text

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2 by Strefford, J C, Sutton, L-A, Baliakas, P, Agathangelidis, A, Malčíková, J, Plevova, K, Scarfó, L, Davis, Z, Stalika, E, Cortese, D, Cahill, N, Pedersen, L B, di Celle, P F, Tzenou, T, Geisler, C, Panagiotidis, P, Langerak, A W, Chiorazzi, N, Pospisilova, S, Oscier, D, Davi, F, Belessi, C, Mansouri, L, Ghia, P, Stamatopoulos, K, Rosenquist, R

“…Recent studies have revealed recurrent mutations of the NOTCH1 , SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive,…”
Get full text

Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity by Marsilio, S, Khiabanian, H, Fabbri, G, Vergani, S, Scuoppo, C, Montserrat, E, Shpall, E J, Hadigol, M, Marin, P, Rai, K R, Rabadan, R, Devereux, S, Pasqualucci, L, Chiorazzi, N

Get full text

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors by Sutton, Lesley-Ann, Young, Emma, Baliakas, Panagiotis, Hadzidimitriou, Anastasia, Moysiadis, Theodoros, Plevova, Karla, Rossi, Davide, Kminkova, Jana, Stalika, Evangelia, Pedersen, Lone Bredo, Malcikova, Jitka, Agathangelidis, Andreas, Davis, Zadie, Mansouri, Larry, Scarfò, Lydia, Boudjoghra, Myriam, Navarro, Alba, Muggen, Alice F, Yan, Xiao-Jie, Nguyen-Khac, Florence, Larrayoz, Marta, Panagiotidis, Panagiotis, Chiorazzi, Nicholas, Niemann, Carsten Utoft, Belessi, Chrysoula, Campo, Elias, Strefford, Jonathan C, Langerak, Anton W, Oscier, David, Gaidano, Gianluca, Pospisilova, Sarka, Davi, Frederic, Ghia, Paolo, Stamatopoulos, Kostas, Rosenquist, Richard

“…We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated…”
Get full text

Inhibition of reactive oxygen species limits expansion of chronic lymphocytic leukemia cells by Yigit, B, Wang, N, Chen, S-S, Chiorazzi, N, Terhorst, C

Get full text

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia by Murphy, E J, Neuberg, D S, Rassenti, L Z, Hayes, G, Redd, R, Emson, C, Li, K, Brown, J R, Wierda, W G, Turner, S, Greaves, A W, Zent, C S, Byrd, J C, McConnel, C, Barrientos, J, Kay, N, Hellerstein, M K, Chiorazzi, N, Kipps, T J, Rai, K R

“…The clinical course of patients with recently diagnosed early stage chronic lymphocytic leukemia (CLL) is highly variable. We examined the relationship between…”
Get full text

A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence by Darzentas, N, Hadzidimitriou, A, Murray, F, Hatzi, K, Josefsson, P, Laoutaris, N, Moreno, C, Anagnostopoulos, A, Jurlander, J, Tsaftaris, A, Chiorazzi, N, Belessi, C, Ghia, P, Rosenquist, R, Davi, F, Stamatopoulos, K

“…Chronic lymphocytic leukemia (CLL) is uniquely characterized by the existence of subsets of cases with quasi-identical, ‘stereotyped’ B-cell receptors (BCRs)…”
Get full text

PATTERNS OF DUVELISIB‐INDUCED LYMPHOCYTOSIS IN PATIENTS WITH R/R CLL OR SLL INCLUDING THOSE WITH HIGH‐RISK FACTORS TREATED IN THE DUO TRIAL by Barrientos, J., Flinn, I., Davids, M.S., Cashen, A., Chiorazzi, N., Chen, S., Hidy, S., Pachter, J., Lustgarten, S., Weaver, D.T., Brown, J.

Get full text

Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability by Cui, X, Zhang, L, Magli, A R, Catera, R, Yan, X-J, Griffin, D O, Rothstein, T L, Barrientos, J, Kolitz, J E, Allen, S L, Rai, K R, Chiorazzi, N, Chu, C C

“…The degree of chronic lymphocytic leukemia (CLL) B-cell antigen receptor (BCR) binding to myosin-exposed apoptotic cells (MEACs) correlates with worse patient…”
Get full text

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors by Fais, F, Ghiotto, F, Hashimoto, S, Sellars, B, Valetto, A, Allen, S L, Schulman, P, Vinciguerra, V P, Rai, K, Rassenti, L Z, Kipps, T J, Dighiero, G, Schroeder, Jr, H W, Ferrarini, M, Chiorazzi, N

“…To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain insight into the potential role…”
Get full text

No Improvement In Long-Term Overall Survival After The Introduction Of Chemo(Immuno)Therapy For Chronic Lymphocytic Leukemia Patients Belonging To Stereotyped Subset #2 by Baliakas, Panagiotis, Mattsson, Mattias, Hadzidimitriou, A., Minga, E., Agathangelidis, A., Sutton, L. A., Scarfo, L., Davis, Z., Yan, X. J., Plevova, K., Sandberg, Y., Vojdeman, F. Juhl, Tzenou, T., Chu, C. C., Veroneze, S., Mansouri, Larry, Smedby, K. E., Giudicelli, V., Nguyen-Khac, F., Panagiotidis, P., Juliusson, G., Anagnostopoulos, A., Lefranc, M. P., Trentin, L., Catherwood, M., Montillo, M., Niemann, C. U., Langerak, A. W., Pospisilova, S., Stavroyianni, N., Chiorazzi, N., Oscier, D., Jelinek, D. F., Shanafelt, T., Darzentas, N., Belessi, C., Davi, F., Ghia, P., Rosenquist, Richard, Stamatopoulos, Kostas

Get full text

Not All IGHV3-21 CLL Are Equal: Subset #2 Displays a Distinctive Clinicobiological Profile with Remarkable Similarities to Subset #169, its Close Immunogenetic Relative by Baliakas, Panagiotis, Hadzidimitriou, A., Sutton, L. A., Minga, E., Agathangelidis, A., Tsanousa, A., Scarfo, L., Davis, Z., Yan, X. J., Shanafelt, T., Plevova, K., Sandberg, Y., Vojdeman, F. J., Boudjogra, M., Tzenou, T., Chatzouli, M., Chu, C. C., Veronese, S., Gardiner, A., Mansouri, Larry, Smedby, K. E., Pedersen, L. B., Moreno, D., Van Lom, K., Giudicelli, V., Francova, H. S., Nguyen-Khac, F., Panagiotidis, P., Juliusson, G., Angelis, L., Anagnostopoulos, A., Lefranc, M. P., Trentin, L., Catherwood, M., Montillo, M., Geisler, C., Langerak, A. W., Pospisilova, S., Chiorazzi, N., Oscier, D., Jelinek, D., Darzentas, N., Belessi, C., Davi, F., Ghia, P., Rosenquist, Richard Brandell, Stamatopoulos, K.

Get full text

Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas by FAIS, F, GAIDANO, G, CAPELLO, D, GLOGHINI, A, GHIOTTO, F, RONCELLA, S, CARBONE, A, CHIORAZZI, N, FERRARINI, M

“…Primary effusion lymphoma (PEL) is a lymphoproliferation of B cells infected by Kaposi's sarcoma-associated herpes-virus/human herpesvirus-8 and reflecting a…”
Get full text

Clinical and laboratory parameters that define clinically relevant B-CLL subgroups by Chiorazzi, N, Allen, S L, Ferrarini, M

“…B cell-type chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease. This is reflected by the very wide-ranging clinical courses that B-CLL patients…”
Get more information

MECHANISMS OF DISEASE: Chronic Lymphocytic Leukemia by Chiorazzi, Nicholas, Rai, Kanti R, Ferrarini, Manlio

“…Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone remarkable changes during the past decade. This review addresses the latest ideas…”
Get full text

Chronic Lymphocytic Leukemia by Chiorazzi, Nicholas, Rai, Kanti R, Ferrarini, Manlio

“…Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone remarkable changes during the past decade. This review addresses the latest ideas…”
Get full text

75 GENE EXPRESSION PROFILING CAN DISTINGUISH PHYSIOLOGIC B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA CLONAL EXPANSIONS FROM PRELEUKEMIC AND LEUKEMIC CLONES by McCarthy, B., Wang, X.-P., Paul, S., Goodwin, L., Rawstron, A., Chiorazzi, N.

“…B-cell chronic lymphocytic leukemia (B-CLL), the most common adult leukemia, is a clonal disease manifested by an absolute lymphocytosis. However, not all…”
Get full text