Search Results - "Chiocco, Matthew"

Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke by Harvey, Brandon K, Airavaara, Mikko, Hinzman, Jason, Wires, Emily M, Chiocco, Matthew J, Howard, Douglas B, Shen, Hui, Gerhardt, Greg, Hoffer, Barry J, Wang, Yun

“…Following the onset of an ischemic brain injury, the excitatory neurotransmitter glutamate is released. The excitotoxic effects of glutamate are a major…”
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Spatial and temporal control of age-related APP processing in genomic-based β-secretase transgenic mice by Chiocco, Matthew J, Lamb, Bruce T

“…Abstract Genetic mutations associated with Alzheimer's disease (AD) in the Amyloid Precursor Protein ( APP ) gene specifically alter the production of the APP…”
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Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice by Chiocco, Matthew J, Kulnane, Laura Shapiro, Younkin, Linda, Younkin, Steve, Evin, Geneviève, Lamb, Bruce T

“…Amyloid-beta (Abeta) the primary component of the senile plaques found in Alzheimer's disease (AD) is generated by the rate-limiting cleavage of amyloid…”
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Neurotrophic factors for the treatment of Parkinson's disease by Chiocco, Matthew J, Harvey, Brandon K, Wang, Yun, Hoffer, Barry J

“…Abstract Parkinson's disease (PD) is a slowly progressive disorder with no known etiology. Pathologically, there is a loss of the dopaminergic neurons in the…”
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A7 Drug discovery approach for rare neurological diseases: using novel zinc finger protein technology to develop potential therapy for huntington’s disease by Chiocco, Matthew, Choi, Vivian, Graham, Anne-Renee, Klatte, Debra, Francone, Omar, Thomson, David, Zeitler, Bryan, Froelich, Steven, Yu, Qi, Paschon, David E, Miller, Jeffrey C, Marlen, Kimberly, Rebar, Edward J, Urnov, Fyodor D, Gregory, Philip D, Steve Zhang, H

“…There are approximately 7000 known rare and orphan diseases, over a third of which affect the central nervous system, virtually all do not have adequate…”
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Targeted Over-Expression of Glutamate Transporter 1 by Harvey, Brandon K, Airavaara, Mikko, Hinzman, Jason, Wires, Emily M, Chiocco, Matthew J, Howard, Douglas B, Shen, Hui, Gerhardt, Greg, Hoffer, Barry J, Wang, Yun

“…Following the onset of an ischemic brain injury, the excitatory neurotransmitter glutamate is released. The excitotoxic effects of glutamate are a major…”
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Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5′UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in Alzheimer's Disease by Chiocco, Matthew J., Zhu, Xuguang, Walther, Donna, Pletnikova, Olga, Troncoso, Juan C., Uhl, George R., Liu, Qing-Rong

“…Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat polymorphisms that are associated with…”
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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease by Chiocco, Matthew J, Zhu, Xuguang, Walther, Donna, Pletnikova, Olga, Troncoso, Juan C, Uhl, George R, Liu, Qing-Rong

“…Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat polymorphisms that are associated with…”
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Beta-secretase transgenic mice: Effects of BACE1 and BACE2 on Alzheimer's disease pathogenesis by Chiocco, Matthew J

“…Numerous investigations have demonstrated that genetic factors play a major role in the etiology of Alzheimer's disease (AD). Identification of mutations in…”
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Beta-secretase transgenic mice: Effects of BACE1 and BACE2 on Alzheimer's disease pathogenesis by Chiocco, Matthew J

“…Numerous investigations have demonstrated that genetic factors play a major role in the etiology of Alzheimer's disease (AD). Identification of mutations in…”
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Altered Amyloid-β Metabolism and Deposition in Genomic-based β-Secretase Transgenic Mice by Matthew J. Chiocco, Laura Shapiro Kulnane, Linda Younkin, Steve Younkin, Geneviève Evin, Bruce T. Lamb

“…Amyloid-β (Aβ) the primary component of the senile plaques found in Alzheimer's disease (AD) is generated by the rate-limiting cleavage of amyloid precursor…”
Get full text