Search Results - "Chiocca, E. Antonio"

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma by Xu, Bo, Tian, Lei, Chen, Jing, Wang, Jing, Ma, Rui, Dong, Wenjuan, Li, Aimin, Zhang, Jianying, Antonio Chiocca, E., Kaur, Balveen, Feng, Mingye, Caligiuri, Michael A., Yu, Jianhua

“…Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune system. CD47, in collaboration with SIRPα, represents an important…”
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Advances in local therapy for glioblastoma — taking the fight to the tumour by van Solinge, Thomas S., Nieland, Lisa, Chiocca, E. Antonio, Broekman, Marike L. D.

“…Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains one of the most treatment-resistant CNS malignancies, and the tumour…”
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Molecular responses to immune checkpoint blockade in glioblastoma by Ito, Hirotaka, Nakashima, Hiroshi, Chiocca, E. Antonio

“…Transcriptional signatures and immune cell infiltrates associated with immune activation distinguish patients with glioblastoma who initially respond to immune…”
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Glial and myeloid heterogeneity in the brain tumour microenvironment by Andersen, Brian M., Faust Akl, Camilo, Wheeler, Michael A., Chiocca, E. Antonio, Reardon, David A., Quintana, Francisco J.

“…Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of patients over the past decade. The brain tumour microenvironment…”
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Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy by Erel-Akbaba, Gulsah, Carvalho, Litia A, Tian, Tian, Zinter, Max, Akbaba, Hasan, Obeid, Pierre J, Chiocca, E. Antonio, Weissleder, Ralph, Kantarci, Ayse Gulten, Tannous, Bakhos A

“…Targeted therapy against the programmed cell death ligand-1 (PD-L1) blockade holds considerable promise for the treatment of different tumor types; however,…”
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions by Wen, Patrick Y, Weller, Michael, Lee, Eudocia Quant, Alexander, Brian M, Barnholtz-Sloan, Jill S, Barthel, Floris P, Batchelor, Tracy T, Bindra, Ranjit S, Chang, Susan M, Chiocca, E Antonio, Cloughesy, Timothy F, DeGroot, John F, Galanis, Evanthia, Gilbert, Mark R, Hegi, Monika E, Horbinski, Craig, Huang, Raymond Y, Lassman, Andrew B, Le Rhun, Emilie, Lim, Michael, Mehta, Minesh P, Mellinghoff, Ingo K, Minniti, Giuseppe, Nathanson, David, Platten, Michael, Preusser, Matthias, Roth, Patrick, Sanson, Marc, Schiff, David, Short, Susan C, Taphoorn, Martin J B, Tonn, Joerg-Christian, Tsang, Jonathan, Verhaak, Roel G W, von Deimling, Andreas, Wick, Wolfgang, Zadeh, Gelareh, Reardon, David A, Aldape, Kenneth D, van den Bent, Martin J

“…Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have…”
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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents by Cho, Choi-Fong, Wolfe, Justin M., Fadzen, Colin M., Calligaris, David, Hornburg, Kalvis, Chiocca, E. Antonio, Agar, Nathalie Y. R., Pentelute, Bradley L., Lawler, Sean E.

“…Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro…”
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The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches by Mineo, Marco, Ricklefs, Franz, Rooj, Arun K., Lyons, Shawn M., Ivanov, Pavel, Ansari, Khairul I., Nakano, Ichiro, Chiocca, E. Antonio, Godlewski, Jakub, Bronisz, Agnieszka

“…Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically…”
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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy by Passaro, Carmela, Alayo, Quazim, De Laura, Isabella, McNulty, John, Grauwet, Korneel, Ito, Hirotaka, Bhaskaran, Vivek, Mineo, Marco, Lawler, Sean E, Shah, Khalid, Speranza, Maria C, Goins, William, McLaughlin, Eric, Fernandez, Soledad, Reardon, David A, Freeman, Gordon J, Chiocca, E Antonio, Nakashima, Hiroshi

“…Glioblastoma (GBM) is resistant to standard of care. Immune checkpoints inhibitors (such as anti-PD-1 mAbs) efficiently restore antitumor T-cell activity. We…”
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The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma by Bhaskaran, Vivek, Nowicki, Michal O., Idriss, Mahmoud, Jimenez, Miguel A., Lugli, Gianmarco, Hayes, Josie L., Mahmoud, Ahmad Bakur, Zane, Rachel E., Passaro, Carmela, Ligon, Keith L., Haas-Kogan, Daphne, Bronisz, Agnieszka, Godlewski, Jakub, Lawler, Sean E., Chiocca, E. Antonio, Peruzzi, Pierpaolo

“…MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically…”
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Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma by Nakashima, Hiroshi, Nguyen, Tran, Kasai, Kazue, Passaro, Carmela, Ito, Hirotaka, Goins, William F, Shaikh, Imran, Erdelyi, Ronald, Nishihara, Reiko, Nakano, Ichiro, Reardon, David A, Anderson, Ana C, Kuchroo, Vijay, Chiocca, E Antonio

“…Glioblastoma (GBM) is the most common primary central nervous system cancer in adults. Oncolytic HSV-1 (oHSV) is the first FDA-approved gene therapy approach…”
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NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy by Otani, Yoshihiro, Yoo, Ji Young, Lewis, Cole T, Chao, Samantha, Swanner, Jessica, Shimizu, Toshihiko, Kang, Jin Muk, Murphy, Sara A, Rivera-Caraballo, Kimberly, Hong, Bangxing, Glorioso, Joseph C, Nakashima, Hiroshi, Lawler, Sean E, Banasavadi-Siddegowda, Yeshavanth, Heiss, John D, Yan, Yuanqing, Pei, Guangsheng, Caligiuri, Michael A, Zhao, Zhongming, Chiocca, E Antonio, Yu, Jianhua, Kaur, Balveen

“…Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely…”
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CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells by Han, Jianfeng, Chu, Jianhong, Keung Chan, Wing, Zhang, Jianying, Wang, Youwei, Cohen, Justus B., Victor, Aaron, Meisen, Walter H., Kim, Sung-hak, Grandi, Paola, Wang, Qi-En, He, Xiaoming, Nakano, Ichiro, Chiocca, E. Antonio, Glorioso III, Joseph C., Kaur, Balveen, Caligiuri, Michael A., Yu, Jianhua

“…Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer of chimeric antigen receptor (CAR)-modified immune cells has emerged…”
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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma by Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

“…Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data…”
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A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases by Chen, Xilin, Han, Jianfeng, Chu, Jianhong, Zhang, Lingling, Zhang, Jianying, Chen, Charlie, Chen, Luxi, Wang, Youwei, Wang, Hongwei, Yi, Long, Elder, J Bradley, Wang, Qi-En, He, Xiaoming, Kaur, Balveen, Chiocca, E Antonio, Yu, Jianhua

“…Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast cancer and indicate a poor prognosis. These tumors are especially…”
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Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal by Godlewski, Jakub, Nowicki, Michal O, Bronisz, Agnieszka, Williams, Shanté, Otsuki, Akihiro, Nuovo, Gerard, Raychaudhury, Abhik, Newton, Herbert B, Chiocca, E Antonio, Lawler, Sean

“…MicroRNAs (miR) show characteristic expression signatures in various cancers and can profoundly affect cancer cell behavior. We carried out miR expression…”
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National Institute of Neurological Disorders and Stroke: current funding status, opportunities, challenges, emerging scientific advances, and recommendations for neurosurgery by Lonser, Russell R, Zipfel, Gregory J, Chiocca, E Antonio

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microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma by Kefas, Benjamin, Godlewski, Jakub, Comeau, Laurey, Li, Yunqing, Abounader, Roger, Hawkinson, Michael, Lee, Jeongwu, Fine, Howard, Chiocca, E Antonio, Lawler, Sean, Purow, Benjamin

“…microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that…”
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Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment by Lawler, Sean E, Chiocca, E Antonio

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Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients by Figueroa, Javier M, Skog, Johan, Akers, Johnny, Li, Hongying, Komotar, Ricardo, Jensen, Randy, Ringel, Florian, Yang, Isaac, Kalkanis, Steven, Thompson, Reid, LoGuidice, Lori, Berghoff, Emily, Parsa, Andrew, Liau, Linda, Curry, William, Cahill, Daniel, Bettegowda, Chetan, Lang, Frederick F, Chiocca, E Antonio, Henson, John, Kim, Ryan, Breakefield, Xandra, Chen, Clark, Messer, Karen, Hochberg, Fred, Carter, Bob S

“…RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids…”
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