Search Results - "Chio, Christine"

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 by Inoue, Satoshi, Hao, Zhenyue, Elia, Andrew J, Cescon, David, Zhou, Lily, Silvester, Jennifer, Snow, Bryan, Harris, Isaac S, Sasaki, Masato, Li, Wanda Y, Itsumi, Momoe, Yamamoto, Kazuo, Ueda, Takeshi, Dominguez-Brauer, Carmen, Gorrini, Chiara, Chio, Iok In Christine, Haight, Jillian, You-Ten, Annick, McCracken, Susan, Wakeham, Andrew, Ghazarian, Danny, Penn, Linda J Z, Melino, Gerry, Mak, Tak W

“…Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or…”
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH by Yun, Jihye, Mullarky, Edouard, Lu, Changyuan, Bosch, Kaitlyn N., Kavalier, Adam, Rivera, Keith, Roper, Jatin, Chio, Iok In Christine, Giannopoulou, Eugenia G., Rago, Carlo, Muley, Ashlesha, Asara, John M., Paik, Jihye, Elemento, Olivier, Chen, Zhengming, Pappin, Darryl J., Dow, Lukas E., Papadopoulos, Nickolas, Gross, Steven S., Cantley, Lewis C.

“…More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that…”
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer by Öhlund, Daniel, Handly-Santana, Abram, Biffi, Giulia, Elyada, Ela, Almeida, Ana S, Ponz-Sarvise, Mariano, Corbo, Vincenzo, Oni, Tobiloba E, Hearn, Stephen A, Lee, Eun Jung, Chio, Iok In Christine, Hwang, Chang-Il, Tiriac, Hervé, Baker, Lindsey A, Engle, Dannielle D, Feig, Christine, Kultti, Anne, Egeblad, Mikala, Fearon, Douglas T, Crawford, James M, Clevers, Hans, Park, Youngkyu, Tuveson, David A

“…Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease…”
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function by Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

“…Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and…”
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Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer by Ponz-Sarvise, Mariano, Corbo, Vincenzo, Tiriac, Hervé, Engle, Dannielle D, Frese, Kristopher K, Oni, Tobiloba E, Hwang, Chang-Il, Öhlund, Daniel, Chio, Iok In Christine, Baker, Lindsey A, Filippini, Dea, Wright, Kevin, Bapiro, Tashinga E, Huang, Pearl, Smith, Paul, Yu, Kenneth H, Jodrell, Duncan I, Park, Youngkyu, Tuveson, David A

“…is mutated in the majority of pancreatic ductal adenocarcinoma. MAPK and PI3K-AKT are primary KRAS effector pathways, but combined MAPK and PI3K inhibition has…”
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Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer by Boutin, Rebecca, Lee, Hiu-Fung, Guan, Tian Lai, Nguyen, Tan Trieu, Huang, Xian Fang, Waller, Daniel D., Lu, Jordan, Christine Chio, Iok In, Michel, René P., Sebag, Michael, Tsantrizos, Youla S.

“…Novel C6-substituted pyrazolo­[3,4-d]­pyrimidine- and C2-substituted purine-based bisphosphonate (C6-PyraP-BP and C2-Pur-BP, respectively) inhibitors of the…”
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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma by Chan, Karina, Robert, Francis, Oertlin, Christian, Kapeller-Libermann, Dana, Avizonis, Daina, Gutierrez, Johana, Handly-Santana, Abram, Doubrovin, Mikhail, Park, Julia, Schoepfer, Christina, Da Silva, Brandon, Yao, Melissa, Gorton, Faith, Shi, Junwei, Thomas, Craig J., Brown, Lauren E., Porco, John A., Pollak, Michael, Larsson, Ola, Pelletier, Jerry, Chio, Iok In Christine

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with limited treatment options. Although metabolic reprogramming is a hallmark of many cancers,…”
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Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development by Ueda, Takeshi, Sasaki, Masato, Elia, Andrew J., Chio, Iok In Christine, Hamada, Koichi, Fukunaga, Rikiro, Mak, Tak W.

“…MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is…”
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma by Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John, Chipuk, Jerry E., Brody, Rachel, Itzkowitz, Steven, Chio, Iok In Christine, Hasson, Dan, Bernstein, Emily, Parsons, Ramon E.

“…Tumors exhibit enhancer reprogramming compared to normal tissue. The etiology is largely attributed to cell-intrinsic genomic alterations. Here, using freshly…”
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Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma by Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John, Chipuk, Jerry E., Brody, Rachel, Itzkowitz, Steven, Chio, Iok In Christine, Hasson, Dan, Bernstein, Emily, Parsons, Ramon E.

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Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity by Lin, Wen-Jye, Su, Yu-Wen, Lu, Yong-Chen, Hao, Zhenyue, Chio, Iok In Christine, Chen, Nien-Jung, Brüstle, Anne, Li, Wanda Y, Mak, Tak Wah

“…TNF receptor-associated factor 2 (TRAF2) is a key intracellular signaling mediator that acts downstream of not only TNFα but also various members of the TNFα…”
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Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation by Dominguez-Brauer, Carmen, Hao, Zhenyue, Elia, Andrew J., Fortin, Jérôme M., Nechanitzky, Robert, Brauer, Patrick M., Sheng, Yi, Mana, Miyeko D., Chio, Iok In Christine, Haight, Jillian, Pollett, Aaron, Cairns, Robert, Tworzyanski, Leanne, Inoue, Satoshi, Reardon, Colin, Marques, Ana, Silvester, Jennifer, Cox, Maureen A., Wakeham, Andrew, Yilmaz, Omer H., Sabatini, David M., van Es, Johan H., Clevers, Hans, Sato, Toshiro, Mak, Tak W.

“…The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule…”
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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors by Chen, Nien-Jung, Chio, Iok In Christine, Lin, Wen-Jye, Duncan, Gordon, Chau, Hien, Katz, David, Huang, Huey-Lan, Pike, Kelly A, Hao, Zhenyue, Su, Yu-Wen, Yamamoto, Kazuo, de Pooter, Renée F, Zúñiga-Pflücker, Juan Carlos, Wakeham, Andrew, Yeh, Wen-Chen, Mak, Tak W

“…Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFα stimulation. In…”
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Softening redox homeostasis in cancer cells by Powers, Justin A., Chio, Iok In Christine

“…Extracellular matrix (ECM) rigidity increases during tumour progression. In a recent study, Romani et al. delineated a connection between ECM stiffness and the…”
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product by Liberti, Maria V., Dai, Ziwei, Wardell, Suzanne E., Baccile, Joshua A., Liu, Xiaojing, Gao, Xia, Baldi, Robert, Mehrmohamadi, Mahya, Johnson, Marc O., Madhukar, Neel S., Shestov, Alexander A., Chio, Iok I. Christine, Elemento, Olivier, Rathmell, Jeffrey C., Schroeder, Frank C., McDonnell, Donald P., Locasale, Jason W.

“…Targeted cancer therapies that use genetics are successful, but principles for selectively targeting tumor metabolism that is also dependent on the environment…”
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A novel TLR 2‐triggered signalling crosstalk synergistically intensifies TNF ‐mediated IL ‐6 induction by Chang, Yu‐Ling, Chen, Tzu‐Hui, Wu, Yi‐Hsiu, Chen, Guann‐An, Weng, Tzu‐Huei, Tseng, Ping‐Hui, Hsieh, Shie‐Liang, Fu, Shu‐Ling, Lin, Chi‐Hung, Chen, Chun‐Jen, Chu, Ching‐Liang, Chio, Iok In Christine, Mak, Tak Wah, Chen, Nien‐Jung

“…Toll‐like receptors ( TLR ) recognize pathogens and trigger the production of vigorous pro‐inflammatory cytokines [such as tumour necrosis factor ( TNF )] that…”
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Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer by Nipp, Ryan D., Ruddy, Margaret, Fuh, Charn‐Xin, Zangardi, Mark L., Chio, Christine, Kim, E. Bridget, Li, Barbara Kong Mui, Long, Ying, Blouin, Gayle C., Lage, Daniel, Ryan, David P., Greer, Joseph A., El‐Jawahri, Areej, Temel, Jennifer S.

“…Background Oncology clinicians often struggle with managing medications and vaccinations in older adults with cancer. We sought to demonstrate the feasibility…”
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Randomized trial of a pharmacy intervention for older adults with cancer by Ruddy, Margaret, El-Jawahri, Areej, Lage, Daniel, Zangardi, Mark, Chio, Christine, Kim, E. Bridget, Li, Barbara Kong Mui, Long, Ying, Blouin, Gayle C., Temel, Jennifer S., Nipp, Ryan David

“…Abstract only…”
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Evaluating oncology pharmacist safety reporting in an outpatient cancer center by Blouin, Gayle C., Chio, Christine, Kim, E. Bridget, McGladrigan, Conor, Bohlen, Nie, Lafleur, Katie

“…Abstract only 238 Background: Safety reporting is imperative because it provides an opportunity to identify and address preventable errors to enhance patient…”
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Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma by DeNicola, Gina M., Chen, Pei-Hsuan, Mullarky, Edouard, Chio, Christine, Asara, John M., Minna, John D., Tuveson, David A., DeBerardinis, Ralph J., Cantley, Lewis C.

“…Tumors have high energetic and anabolic needs for rapid growth and proliferation, and the serine biosynthetic pathway has recently been identified as an…”
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