Search Results - "Chintha, Venkataramaiah"
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Therapeutic potentiality of a new flavonoid against ketamine induced glutamatergic dysregulation in schizophrenia: In vivo and in silico approach
Published in Biomedicine & pharmacotherapy (01-06-2021)“…Glutamate and dopamine hypotheses are leading theories of the pathophysiology of schizophrenia. Multiple lines of evidence suggest that dopaminergic and…”
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Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin
Published in PloS one (03-11-2022)“…The present study intends to formulate, characterize and appraise the phospholipid-based nanovesicular system for enhanced delivery of Hesperetin (HT). The…”
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3
Green synthesis, antibacterial, antiviral and molecular docking studies of α-aminophosphonates
Published in Synthetic communications (01-09-2020)“…An efficient method for the synthesis of α-aminophosphonate derivatives has been developed with different functional groups under catalyst and solvent free…”
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4
Biphenyl Backbone-Based (Bis)Urea and (Bis)Thiourea Derivatives as Antimicrobial and Antioxidant Agents and Evaluation of Docking Studies and ADME Properties
Published in Polycyclic aromatic compounds (09-08-2023)“…In the present study, a new series of (bis)ureas 11(a-f) and (bis)thioureas 13(a-f) of 3,3'-dimethoxy-[1,1'-biphenyl]-4,4'-diamine dihydrochloride (9) has been…”
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5
Green synthesis, molecular docking, anti-oxidant and anti-inflammatory activities of α-aminophosphonates
Published in Medicinal chemistry research (01-10-2019)“…The naturally viable α -amino acid surrogates have been synthesised via Kabachnik–Fields reaction by the condensation of 2-aminothiazole with various aldehydes…”
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Synthesis and anti-diabetic activity evaluation of phosphonates containing thiazolidinedione moiety
Published in Phosphorus, sulfur, and silicon and the related elements (02-07-2020)“…A sequence of substituted phosphonates containing the thiazolidinedione moiety was synthesized with good yields. The structures of all the synthesized…”
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Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking Studies of Carbamoyl Phosphonates
Published in Russian journal of organic chemistry (01-12-2023)“…A novel class of carbamoyl phosphonates derivatives of dimethyl, ethyl, and aryl phosphonates were prepared by one-pot synthesis through treatment with…”
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8
Anti-Obesity and Lipid Lowering Activity of Bauhiniastatin-1 is Mediated Through PPAR-γ/AMPK Expressions in Diet-Induced Obese Rat Model
Published in Frontiers in pharmacology (22-07-2021)“…Objective: To evaluate the therapeutic efficacy and underlying molecular mechanisms of Bauhiniastatin-1 (BSTN1) to alleviate adiposity in diet-induced obese…”
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9
Alcohol exacerbated biochemical and biophysical alterations in liver mitochondrial membrane of diabetic male wistar rats – A possible amelioration by green tea
Published in Clinical nutrition open science (01-04-2022)“…The biological membranes are important for cell structure and function but, during diseased conditions such as diabetes and in chronic alcoholism, they may be…”
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10
Pharmacological Potentiality of Bioactive Flavonoid against Ketamine Induced Cell Death of PC 12 Cell Lines: An In Vitro Study
Published in Antioxidants (09-06-2021)“…During the past few years, there has been exponential growth in the field of ethnopharmacology in the treatment of different human ailments, including…”
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Design and synthesis of novel 1,3,2-benzoxazaphosphinine-2-one derivatives: an in vitro biological evaluation and in silico approaches
Published in Phosphorus, sulfur, and silicon and the related elements (06-01-2021)“…A new class of benzoxazaphosphinine-2-one derivatives were synthesized by the reaction of 2-(3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazol-2-yl)phenol with…”
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12
Modulations in the ATPases during ketamine-induced schizophrenia and regulatory effect of "3-(3, 4-dimethoxy phenyl) -1- (4-methoxyphenyl) prop-2-en-1-one": an in vivo and in silico studies
Published in Journal of receptors and signal transduction (03-03-2020)“…Schizophrenia is a devastating illness and displays a wide range of psychotic symptoms. Accumulating evidence indicate impairment of bioenergetic pathways…”
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Isolation and neuroprotective prospective of novel bioactive compound "3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one" against ketamine-induced cognitive deficits in schizophrenia: an experimental study
Published in Natural product research (04-03-2022)“…For the first time a new flavonoid compound is isolated from the seeds of (CP) using different chromatographic techniques and it's structure is predicted as…”
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14
Bioavailability and Neuroprotectivity of 3-(3, 4-dimethoxy phenyl)-1-4 (methoxy phenyl) prop-2-en-1-one against Schizophrenia: an in silico approach
Published in Journal of receptors and signal transduction (02-11-2019)“…Schizophrenia is a major debilitating disorder worldwide. Schizophrenia is a result of multi-gene mutation and psycho-social factors. Mutated amino acid…”
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15
Perturbations in the catecholamine metabolism and protective effect of "3-(3, 4-dimethoxy phenyl)-1-4(methoxy phenyl) prop-2-en-1-one" during ketamine-induced schizophrenia: an in vivo and in silico studies
Published in Journal of biomolecular structure & dynamics (03-07-2021)“…Different kinds of secondary metabolites present in the medicinal plants play an important role to alleviate different human ailments including…”
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16
Preparation, characterization, and evaluation
Published in PloS one (03-11-2022)“…The present study intends to formulate, characterize and appraise the phospholipid-based nanovesicular system for enhanced delivery of Hesperetin (HT). The…”
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17
An efficient nano-FGT catalyzed green synthesis of α-aminophosphonates and evaluation of their antioxidant, anti-inflammatory activity and molecular docking studies
Published in Synthetic communications (02-01-2022)“…A green and efficient one-pot has been developed for the synthesis of a series of new diethyl-(((2,3-dihydrobenzo[b][1, 4] dioxin-6yl)amino)(substituted…”
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18
In silico docking studies and synthesis of new phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole as potential antimicrobial agents
Published in Journal of receptors and signal transduction (02-09-2020)“…A new class of phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole were synthesized in good to excellent yields (78-96%) by an in situ,…”
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19
In silico, in ovo and in vitro antiviral efficacy of phosphorylated derivatives of abacavir: an experimental approach
Published in Journal of receptors and signal transduction (02-09-2020)“…Outstanding increase of oral absorption, bioavailability, and antiviral efficacy of phosphorylated nucleosides and basic antiviral influence of abacavir is the…”
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20
In silico molecular docking and in vitro antioxidant activity studies of novel α-aminophosphonates bearing 6-amino-1,3-dimethyl uracil
Published in Journal of receptors and signal transduction (03-03-2020)“…In the present study, a new series of α-Aminophosphonates bearing 6-amino-1,3-dimethyluracil was synthesized in good to excellent yields (78-95%) by one-pot,…”
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