Search Results - "Chintala, Shravan K."

Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells by Ganesh, Bhagyalaxmi S, Chintala, Shravan K

“…Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma. Although a majority of studies to date have concentrated on…”
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Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy by Chintala, Shravan K, Pan, Jinhong, Satapathy, Sandeep, Condruti, Rebecca, Hao, Zixuan, Liu, Pei-Wen, O'Conner, Christian F, Barr, Joseph T, Wilson, Mark R, Jeong, Shinwu, Fini, M Elizabeth

“…There is a significant unmet need for therapeutics to treat ocular surface barrier damage, also called epitheliopathy, due to dry eye and related diseases. We…”
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Dynasore protects the ocular surface against damaging oxidative stress by Webster, Andrew, Chintala, Shravan K, Kim, Jasmine, Ngan, Michelle, Itakura, Tatsuo, Panjwani, Noorjahan, Argüeso, Pablo, Barr, Joseph T, Jeong, Shinwu, Fini, M Elizabeth

“…Water soluble "vital" dyes are commonly used clinically to evaluate health of the ocular surface; however, staining mechanisms remain poorly understood. Recent…”
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Regulatory Effects of GPR158 Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways by Suarez, Maria Fernanda, Itakura, Tatsuo, Pany, Satyabrata, Jeong, Shinwu, Chintala, Shravan K., Raizman, Michael B., Riesinger, Steven, Lazarova, Tsvetelina, Echenique, José, Serra, Horacio M., Stamer, W. Daniel, Fini, M. Elizabeth

“…Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The…”
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Kainic Acid-Mediated Upregulation of Matrix Metalloproteinase-9 Promotes Retinal Degeneration by Zhang, Xu, Cheng, Mei, Chintala, Shravan K

“…Excitotoxicity has been proposed to play a pivotal role in retinal damage, but the mechanisms that underlie retinal damage are not clearly understood. In this…”
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Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype by Schuman, Joel S, Wang, Nan, Chintala, Shravan K, Fini, M. Elizabeth

“…The glaucomas are a group of optic neuropathies comprising the leading cause of irreversible blindness worldwide. Elevated intraocular pressure due to a…”
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Deficiency in Matrix Metalloproteinase Gelatinase B (MMP-9) Protects against Retinal Ganglion Cell Death after Optic Nerve Ligation by Chintala, Shravan K., Zhang, Xu, Austin, Jeffrey S., Fini, M. Elizabeth

“…Loss of retinal ganglion cells is the final end point in blinding diseases of the optic nerve such as glaucoma. To enable the use of mouse genetics to…”
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Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration by Mohan, Royce, Chintala, Shravan K., Jung, Jae Chang, Villar, Winston V.L., McCabe, Frank, Russo, Laoti A., Lee, Yunhee, McCarthy, Brendan E., Wollenberg, Kurt R., Jester, James V., Wang, Min, Welgus, Howard G., Shipley, J. Michael, Senior, Robert M., Fini, M. Elizabeth

“…We studied the role of the matrix metalloproteinase gelatinase B (gelB; MMP-9) in epithelial regeneration using the gelB-deficient mouse. We report the novel…”
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Plasminogen activators promote excitotoxicity-induced retinal damage by Mali, Raghuveer S, Cheng, Mei, Chintala, Shravan K

“…Increased levels of extracellular L-glutamate have been suggested to play a role in retinal damage in a number of blinding diseases such as glaucoma and…”
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Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma by Chintala, Shravan K.

“…Elevated intraocular pressure (IOP) promotes the degeneration of retinal ganglion cells (RGCs) during the progression of Primary Open-Angle Glaucoma (POAG)…”
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Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons by Massoll, Charlotte, Mando, Wasym, Chintala, Shravan K

“…This study investigated the role of sterile alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like degeneration of…”
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Influence of interleukin-1 beta induction and mitogen-activated protein kinase phosphorylation on optic nerve ligation-induced matrix metalloproteinase-9 activation in the retina by Zhang, Xu, Chintala, Shravan K.

“…Ischemic damage to the retina is a multifaceted process that results in irreversible loss of ganglion cells and blinding disease. Although the mechanisms…”
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Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN by KOUL, Dimpy, PARTHASARATHY, Ranjani, YUNG, W. K, RUIJUN SHEN, DAVIES, Michael A, JASSER, Samar A, CHINTALA, Shravan K, RAO, Jasti S, YI SUN, BENVENISITE, Etty N, LIU, Ta-Jen

“…Human gliomas are highly invasive, and remain to be a major obstacle for any effective therapeutic remedy. Among many other factors, gliomas express elevated…”
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Down-Regulation of RNA 3'-Terminal Phosphate Cyclase Attenuates Toll-Like Receptor 3-Mediated Axonal Loss in the Retina and Optic Nerve by Chintala, Shravan K, Daram, Naveena

“…To investigate the role of RNA 3'-terminal phosphate cyclase (Rtca) in Toll-like receptor 3 (TLR3)-mediated loss of retinal ganglion cells (RGCs) and their…”
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Optic nerve ligation leads to astrocyte-associated matrix metalloproteinase-9 induction in the mouse retina by Zhang, Xu, Cheng, Mei, Chintala, Shravan K.

“…Ischemic damage results in irreversible ganglion cell loss in the retina. While the mechanisms underlying ischemia-induced ganglion cell loss are not clearly…”
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Dynasore protects the ocular surface against damaging stress by Webster, Andrew, Chintala, Shravan K, Kim, Jasmine, Ngan, Michelle, Itakura, Tatsuo, Panjwani, Noorjahan, Argüeso, Pablo, Barr, Joseph T, Jeong, Shinwu, Elizabeth Fini, M

“…Water soluble "vital" dyes are commonly used clinically to evaluate health of the ocular surface; however, staining mechanisms remain poorly understood. Recent…”
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Curcumin attenuates staurosporine-mediated death of retinal ganglion cells by Burugula, Balabharathi, Ganesh, Bhagyalaxmi S, Chintala, Shravan K

“…Staurosporine (SS) causes retinal ganglion cell (RGC) death in vivo, but the underlying mechanisms have been unclear. Since previous studies on RGC-5 cells…”
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Intravitreous Injection of a Membrane Depolarization Agent Causes Retinal Degeneration Via Matrix Metalloproteinase-9 by Mali, Raghuveer S, Cheng, Mei, Chintala, Shravan K

“…Membrane depolarization and subsequent synaptic release of l-glutamate have been implicated in ischemic retinal damage. However, the mechanisms that lead to…”
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Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3 by Chintala, Shravan K, Putris, Nahrain, Geno, Mason

“…To investigate whether activation of Toll-like receptor 3 (TLR3) promotes the degeneration of retinal ganglion cells (RGCs) by upregulating the protein levels…”
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PARP‐1/PAR Activity in Cultured Human Lens Epithelial Cells Exposed to Two Levels of UVB Light by Cencer, Caroline S., Chintala, Shravan K., Townsend, Tenira J., Feldmann, Daniel P., Awrow, Mirna A., Putris, Nahrain A., Geno, Mason E., Donovan, Maria G., Giblin, Frank J.

“…This study investigated poly(ADP‐ribose) polymerase‐1 (PARP‐1) activation in cultured human lens epithelial cells exposed to two levels of UVB light (312 nm…”
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