Search Results - "Chino, Naoyoshi"

Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection by Yanagi, Shigehisa, Ashitani, Jun-ichi, Ishimoto, Hiroshi, Date, Yukari, Mukae, Hiroshi, Chino, Naoyoshi, Nakazato, Masamitsu

“…Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was…”
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cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels by Ostrow, Kimberly Laskie, Mammoser, Aaron, Suchyna, Tom, Sachs, Frederick, Oswald, Robert, Kubo, Shigeru, Chino, Naoyoshi, Gottlieb, Philip A

“…The peptide GsMTx4 from the tarantula venom ( Grammostola spatulata) inhibits mechanosensitive ion channels. In this work, we report the cDNA sequence encoding…”
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The Intermediate Form of Glycine-Extended Adrenomedullin Is the Major Circulating Molecular Form in Human Plasma by Kitamura, Kazuo, Kato, Johji, Kawamoto, Mari, Tanaka, Miho, Chino, Naoyoshi, Kangawa, Kenji, Eto, Tanenao

“…Adrenomedullin (AM), a potent vasodilator peptide, is processed from its AM precursor as glycine-extended AM (AM-gly), an intermediate form of AM…”
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High-Resolution X-ray Structure of the Unexpectedly Stable Dimer of the [Lys(-2)-Arg(-1)-des(17−21)]Endothelin-1 Peptide by Hoh, François, Cerdan, Rachel, Kaas, Quentin, Nishi, Yoshinori, Chiche, Laurent, Kubo, Shigeru, Chino, Naoyoshi, Kobayashi, Yuji, Dumas, Christian, Aumelas, André

“…Previous structural studies on the [Lys(-2)-Arg(-1)]endothelin-1 peptide (KR-ET-1), 540-fold less potent than ET-1, strongly suggested the presence of an…”
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Structure-activity relationship of endothelin: importance of charged groups by Nakajima, K, Kubo, S, Kumagaye, S, Nishio, H, Tsunemi, M, Inui, T, Kuroda, H, Chino, N, Watanabe, T X, Kimura, T

“…Endothelin (ET)-related peptides including ET-1 (1-39) were synthesized, and their constricting activity in rat pulmonary artery rings and pressor activity in…”
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Topological isomers of human uroguanylin: interconversion between biologically active and inactive isomers by Chino, Naoyoshi, Kubo, Shigeru, Kitani, Tetsuya, Yoshida, Takuya, Tanabe, Ryosuke, Kobayashi, Yuji, Nakazato, Masamitsu, Kangawa, Kenji, Kimura, Terutoshi

“…The solution structures of the two compounds of human uroguanylin (I and II), which were generated during disulfide bond forming reaction, were found to be…”
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[Lys(-2)-Arg(-1)]Endothelin-1 Solution Structure by Two-Dimensional 1H-NMR: Possible Involvement of Electrostatic Interactions in Native Disulfide Bridge Formation and in Biological Activity Decrease by Aumelas, Andre, Chiche, Laurent, Kubo, Shigeru, Chino, Naoyoshi, Tamaoki, Haruhiko, Kobayashi, Yuji

“…Addition of the Lys(-2)-Arg(-1) dipeptide, present in the precursor protein, to the N-terminus of endothelin-1 (ET-1), to form a 23-residue peptide (KR-ET-1)…”
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Identification of Human β-Defensin-2 in Respiratory Tract and Plasma and Its Increase in Bacterial Pneumonia by Hiratsuka, Takeaki, Nakazato, Masamitsu, Date, Yukari, Ashitani, Jun-ichi, Minematsu, Toshio, Chino, Naoyoshi, Matsukura, Shigeru

“…Human β-defensin-2 (hBD-2), a novel antimicrobial peptide, was originally isolated from human skin. We found that synthetic hBD-2 has high bactericidal…”
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Improvement in the oxidative folding of endothelin-1 by a lys-Arg extension at the amino terminus: Implication of a salt bridge between Arg−1 and Asp8 by Kubo, Shigeru, Chino, Naoyoshi, Nakajima, Kiichiro, Aumelas, André, Chiche, Laurent, Segawa, Shin-ichi, Tamaoki, Haruhiko, Kobayashi, Yuji, Kimura, Terutoshi, Sakakibara, Shumpei

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Optimization of the Oxidative Folding Reaction and Disulfide Structure Determination of Human α-Defensin 1, 2, 3 and 5 by Kubo, Shigeru, Tanimura, Kyoko, Nishio, Hideki, Chino, Naoyoshi, Teshima, Tadashi, Kimura, Terutoshi, Nishiuchi, Yuji

“…The optimal conditions were determined for oxidative folding of the reduced human α-defensins, HNP1, HNP2, HNP3 and HD5, preferentially into their native…”
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Optimization of the Oxidative Folding Reaction and Disulfide Structure Determination of Human [alpha]-Defensin 1, 2, 3 and 5 by Kubo, Shigeru, Tanimura, Kyoko, Nishio, Hideki, Chino, Naoyoshi, Teshima, Tadashi, Kimura, Terutoshi, Nishiuchi, Yuji

“…The optimal conditions were determined for oxidative folding of the reduced human α-defensins, HNP1, HNP2, HNP3 and HD5, preferentially into their native…”
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Chemical Synthesis of Human β-Defensin (hBD)-1, -2, -3 and -4: Optimization of the Oxidative Folding Reaction by Chino, Naoyoshi, Kubo, Shigeru, Nishio, Hideki, Nishiuchi, Yuji, Nakazato, Masamitsu, Kimura, Terutoshi

“…Reduced human beta -defensin (hBD)-1, -2, -3 and -4 synthesized by Boc chemistry were subjected to oxidative folding reaction under optimal conditions. Among…”
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Isolation of human [beta]-defensin-4 in lung tissue and its increase in lower respiratory tract infection by Yanagi, Shigehisa, Ashitani, Jun-ichi, Ishimoto, Hiroshi, Date, Yukari, Mukae, Hiroshi, Chino, Naoyoshi, Nakazato, Masamitsu

“…Background Human [beta]-defensin-4 (hBD-4), a new member of the [beta]-defensin family, was discovered by an analysis of the genomic sequence. The objective of…”
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Structural analysis of human beta-defensin-1 and its significance in urinary tract infection by Hiratsuka, T, Nakazato, M, Ihi, T, Minematsu, T, Chino, N, Nakanishi, T, Shimizu, A, Kangawa, K, Matsukura, S

“…Human beta-defensin-1 (hBD-1) is a 36-amino-acid antimicrobial peptide that functions in the host innate defense. We developed a highly sensitive…”
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The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations by Kaas, Quentin, Aumelas, André, Kubo, Shigeru, Chino, Naoyoshi, Kobayashi, Yuji, Chiche, Laurent

“…The [des(17-21)]-endothelin-1 (CSH-ET) and [Lys(-)(2)-Arg(-)(1)-des(17-21)]-endothelin-1 (KR-CSH-ET) peptides, designed by removing the five-residue…”
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The [Lys-2-Arg-1-des(17−21)]-Endothelin-1 Peptide Retains the Specific Arg-1−Asp8 Salt Bridge but Reveals Discrepancies between NMR Data and Molecular Dynamics Simulations by Kaas, Quentin, Aumelas, André, Kubo, Shigeru, Chino, Naoyoshi, Kobayashi, Yuji, Chiche, Laurent

“…The [des(17−21)]-endothelin-1 (CSH-ET) and [Lys-2-Arg-1-des(17−21)]-endothelin-1 (KR-CSH-ET) peptides, designed by removing the five-residue hydrophobic tail…”
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The [Lys - 2 -Arg - 1 -des(17−21)]-Endothelin-1 Peptide Retains the Specific Arg - 1 −Asp 8 Salt Bridge but Reveals Discrepancies between NMR Data and Molecular Dynamics Simulations by Kaas, Quentin, Aumelas, André, Kubo, Shigeru, Chino, Naoyoshi, Kobayashi, Yuji, Chiche, Laurent

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Chemical Synthesis of Human [beta]-Defensin (hBD)-1, -2, -3 and -4: Optimization of the Oxidative Folding Reaction by Chino, Naoyoshi, Kubo, Shigeru, Nishio, Hideki, Nishiuchi, Yuji, Nakazato, Masamitsu, Kimura, Terutoshi

“…Issue Title: Australian Peptide Conference Issue Reduced human β-defensin (hBD)-1, -2, -3 and -4 synthesized by Boc chemistry were subjected to oxidative…”
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Analysis of hypotensive mechanisms of human and rat adrenomedullin in anesthetized rat by Itahara, Yukako, Watanabe, Takushi X., Inui, Tatsuya, Chino, Naoyoshi, Kimura, Terutoshi, Sakakibara, Shumpei

“…Adrenomedullin is a novel hypotensive peptide isolated from human pheochromocytoma (Biochem. Biophys. Res. Commun. 192, 553-560 (1993)). This peptide,…”
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Identification of Biologically Active and Inactive Human Uroguanylins in Plasma and Urine and Their Increases in Renal Insufficiency by Nakazato, Masamitsu, Yamaguchi, Hideki, Kinoshita, Hiroshi, Kangawa, Kenji, Matsuo, Hisayuki, Chino, Naoyoshi, Matsukura, Shigeru

“…Uroguanylin, a 16-amino acid peptide, is an endogenous activator of intestinal and possibly renal guanylate cyclase C (GC-C). Using two synthetic topological…”
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