Search Results - "Chinnapen, Daniel J.F."

Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease by Cho, Jin Ah, Chinnapen, Daniel J.F.

“…Mucosal surfaces that line our gastrointestinal tract are continuously exposed to trillions of bacteria that form a symbiotic relationship and impact host…”
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Membrane Transport across Polarized Epithelia by Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, Lencer, Wayne I

“…Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers between the external environment and the internal milieu. To…”
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A monovalent streptavidin with a single femtomolar biotin binding site by Ting, Alice Y, Howarth, Mark, Chinnapen, Daniel J-F, Gerrow, Kimberly, Dorrestein, Pieter C, Grandy, Melanie R, Kelleher, Neil L, El-Husseini, Alaa

“…Streptavidin and avidin are used ubiquitously because of the remarkable affinity of their biotin binding, but they are tetramers, which disrupts many of their…”
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Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER by Chinnapen, Daniel J.-F., Chinnapen, Himani, Saslowsky, David, Lencer, Wayne I.

“…Abstract Cholera toxin (CT), and members of the AB5 family of toxins enter host cells and hijack the cell's endogenous pathways to induce toxicity. CT binds to…”
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Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1 by Chinnapen, Daniel J.-F., Hsieh, Wan-Ting, te Welscher, Yvonne M., Saslowsky, David E., Kaoutzani, Lydia, Brandsma, Eelke, D'Auria, Ludovic, Park, Hyejung, Wagner, Jessica S., Drake, Kimberly R., Kang, Minchul, Benjamin, Thomas, Ullman, M. David, Costello, Catherine E., Kenworthy, Anne K., Baumgart, Tobias, Massol, Ramiro H., Lencer, Wayne I.

“…The glycosphingolipid GM1 binds cholera toxin (CT) on host cells and carries it retrograde from the plasma membrane (PM) through endosomes, the trans-Golgi…”
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Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum by Wernick, Naomi L B, Chinnapen, Daniel J-F, Cho, Jin Ah, Lencer, Wayne I

“…Cholera toxin (CT), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the…”
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Ganglioside GM1-mediated Transcytosis of Cholera Toxin Bypasses the Retrograde Pathway and Depends on the Structure of the Ceramide Domain by Saslowsky, David E., te Welscher, Yvonne M., Chinnapen, Daniel J.-F., Wagner, Jessica S., Wan, Joy, Kern, Eli, Lencer, Wayne I.

“…Cholera toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized intestinal epithelial cells and trafficking retrograde…”
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Genetic architecture underlying changes in carotenoid accumulation during the evolution of the blind Mexican cavefish, Astyanax mexicanus by Riddle, Misty R., Aspiras, Ariel C., Damen, Fleur, Hutchinson, John N., Chinnapen, Daniel J.‐F., Tabin, Julius, Tabin, Clifford J.

“…Carotenoids are lipid‐soluble yellow to orange pigments produced by plants, bacteria, and fungi. They are consumed by animals and metabolized to produce…”
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Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers by Duclos, Richard I., Blue, Kiara D., Rufo, Michael J., Chen, Xiaoling, Guo, Jason J., Ma, Xiaoyu, Lencer, Wayne I., Chinnapen, Daniel J.F.

“…[Display omitted] Robust transport of therapeutic peptides and other medicinal molecules across tight epithelial barriers would overcome the major obstacle to…”
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Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2 by Saslowsky, David E, Cho, Jin Ah, Chinnapen, Himani, Massol, Ramiro H, Chinnapen, Daniel J-F, Wagner, Jessica S, De Luca, Heidi E, Kam, Wendy, Paw, Barry H, Lencer, Wayne I

“…Cholera toxin (CT) causes the massive secretory diarrhea associated with epidemic cholera. To induce disease, CT enters the cytosol of host cells by co-opting…”
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A Deoxyribozyme That Harnesses Light to Repair Thymine Dimers in DNA by Daniel J.-F. Chinnapen, Sen, Dipankar

“…In vitro selection was used to investigate whether nucleic acid enzymes are capable of catalyzing photochemical reactions. The reaction chosen was…”
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Microtubule Motors Power Plasma Membrane Tubulation in Clathrin‐Independent Endocytosis by Day, Charles A., Baetz, Nicholas W., Copeland, Courtney A., Kraft, Lewis J., Han, Bing, Tiwari, Ajit, Drake, Kimberly R., De Luca, Heidi, Chinnapen, Daniel J.‐F., Davidson, Michael W., Holmes, Randall K., Jobling, Michael G., Schroer, Trina A., Lencer, Wayne I., Kenworthy, Anne K.

“…How the plasma membrane is bent to accommodate clathrin‐independent endocytosis remains uncertain. Recent studies suggest Shiga and cholera toxin induce…”
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Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1 by te Welscher, Yvonne M., Chinnapen, Daniel J.-F., Kaoutzani, Lydia, Mrsny, Randall J., Lencer, Wayne I.

“…The incretin hormone Glucagon-like peptide 1 (GLP-1) requires delivery by injection for the treatment of Type 2 diabetes mellitus. Here, we test if the…”
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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids by Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, Te Welscher, Yvonne M, Gonzalez, Rodrigo J, Softic, Samir, Pacheco, Michele, Mrsny, Randall J, Kahn, C Ronald, von Andrian, Ulrich H, Lau, Jesper, Pentelute, Bradley L, Lencer, Wayne I

“…Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here,…”
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Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins by Cho, Jin A, Chinnapen, Daniel J-F, Aamar, Emil, te Welscher, Yvonne M, Lencer, Wayne I, Massol, Ramiro

“…Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the…”
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A Deoxyribozyme, Sero1C, Uses Light and Serotonin to Repair Diverse Pyrimidine Dimers in DNA by Thorne, Rebecca E., Chinnapen, Daniel J.-F., Sekhon, Gurpreet S., Sen, Dipankar

“…An in vitro selection search for DNAs capable of catalyzing photochemistry yielded two distinctive deoxyribozymes (DNAzymes) with photolyase activity: UV1C,…”
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Towards Elucidation of the Mechanism of UV1C, a Deoxyribozyme with Photolyase Activity by Chinnapen, Daniel J.-F., Sen, Dipankar

“…Among the unexpected chemistries that can be catalyzed by nucleic acid enzymes is photochemistry. We have reported the in vitro selection of a small,…”
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Hemin-Stimulated Docking of Cytochrome c to a Hemin−DNA Aptamer Complex by Chinnapen, Daniel J. F, Sen, Dipankar

“…DNA aptamers were selected for their ability to bind simultaneously to the protein cytochrome c and to the metalloporphyrin hemin. Such aptamers each contained…”
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