Search Results - "Chines, P"

Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns by MOHLKE, Karen L, JACKSON, Anne U, NARISU, Narisu, ENLOE, Sareena, VALLE, Timo T, TUOMILEHTO, Jaakko, BERGMAN, Richard N, BOEHNKE, Michael, COLLINS, Francis S, SCOTT, Laura J, PECK, Erin C, SUH, Yong D, CHINES, Peter S, WATANABE, Richard M, BUCHANAN, Thomas A, CONNEELY, Karen N, ERDOS, Michael R

“…Mitochondria play an integral role in ATP production in cells and are involved in glucose metabolism and insulin secretion, suggesting that variants in the…”
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Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome by McCord, Rachel Patton, Nazario-Toole, Ashley, Zhang, Haoyue, Chines, Peter S, Zhan, Ye, Erdos, Michael R, Collins, Francis S, Dekker, Job, Cao, Kan

“…Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA. This…”
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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants by Parker, Stephen C. J., Stitzel, Michael L., Taylor, D. Leland, Orozco, Jose Miguel, Erdos, Michael R., Akiyama, Jennifer A., van Bueren, Kelly Lammerts, Chines, Peter S., Narisu, Narisu, Black, Brian L., Visel, Axel, Pennacchio, Len A., Collins, Francis S.

“…Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene…”
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Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns by Mohlke, K L, Lange, E M, Valle, T T, Ghosh, S, Magnuson, V L, Silander, K, Watanabe, R M, Chines, P S, Bergman, R N, Tuomilehto, J, Collins, F S, Boehnke, M

“…Linkage disequilibrium (LD) is a proven tool for evaluating population structure and localizing genes for monogenic disorders. LD-based methods may also help…”
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Methionine Synthase: High-Resolution Mapping of the Human Gene and Evaluation as a Candidate Locus for Neural Tube Defects by Brody, Lawrence C., Baker, Priscilla J., Chines, Peter S., Musick, Anjene, Molloy, Anne M., Swanson, Deborah A., Kirke, Peadar N., Ghosh, Soumitra, Scott, John M., Mills, James L.

“…Periconceptual folate supplementation has been found to prevent the occurrence of many neural tube defects (NTDs). Consequently, genetic variation in folate…”
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Type 2 Diabetes: Evidence for Linkage on Chromosome 20 in 716 Finnish Affected Sib Pairs by Ghosh, Soumitra, Watanabe, Richard M., Hauser, Elizabeth R., Valle, Timo, Magnuson, Victoria L., Erdos, Michael R., Langefeld, Carl D., Balow, James, Ally, Delphine S., Kohtamaki, Kimmo, Chines, Peter, Birznieks, Gunther, Kaleta, Hong-Shi, Musick, Anjene, Te, Catherine, Tannenbaum, Joyce, Eldridge, William, Shapiro, Shane, Martin, Colin, Witt, Alyson, So, Alistair, Chang, Jennie, Shurtleff, Ben, Porter, Rachel, Kudelko, Kristina, Unni, Arun, Segal, Leonid, Sharaf, Ravi, Blaschak-Harvan, Jillian, Eriksson, Johan, Tenkula, Tuula, Vidgren, Gabriele, Ehnholm, Christian, Tuomilehto-Wolf, Eva, Hagopian, William, Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., Boehnke, Michael

“…We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477…”
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Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database by Willer, Cristen J., Scott, Laura J., Bonnycastle, Lori L., Jackson, Anne U., Chines, Peter, Pruim, Randall, Bark, Craig W., Tsai, Ya-Yu, Pugh, Elizabeth W., Doheny, Kimberly F., Kinnunen, Leena, Mohlke, Karen L., Valle, Timo T., Bergman, Richard N., Tuomilehto, Jaakko, Collins, Francis S., Boehnke, Michael

“…The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [:2003 Nature…”
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Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers by Ghosh, S, Karanjawala, ZE, Hauser, E R, Ally, D, Knapp, JI, Rayman, J B, Musick, A, Tannenbaum, J, Te, C

“…Large-scale genotyping is required to generate dense identity-by-descent maps to map genes for human complex disease. In some studies the number of genotypes…”
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Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes by SILANDER, Kaisa, MOHLKE, Karen L, CHINES, Peter S, ERDOS, Michael R, NARISU, Narisu, CONNEELY, Karen N, CHUN LI, FINGERLIN, Tasha E, DHANJAL, Sharanjeet K, VALLE, Timo T, BERGMAN, Richard N, TUOMILEHTO, Jaakko, SCOTT, Laura J, WATANABE, Richard M, BOEHNKE, Michael, COLLINS, Francis S, PECK, Erin C, HOLLSTEIN, Pablo, SKOL, Andrew D, JACKSON, Anne U, DELOUKAS, Panagiotis, HUNT, Sarah, STAVRIDES, George

“…Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes Kaisa Silander 1 , Karen L. Mohlke 1 , Laura J. Scott 2…”
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Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group by Ghosh, S, Karanjawala, Z E, Hauser, E R, Ally, D, Knapp, J I, Rayman, J B, Musick, A, Tannenbaum, J, Te, C, Shapiro, S, Eldridge, W, Musick, T, Martin, C, Smith, J R, Carpten, J D, Brownstein, M J, Powell, J I, Whiten, R, Chines, P, Nylund, S J, Magnuson, V L, Boehnke, M, Collins, F S

“…Large-scale genotyping is required to generate dense identity-by-descent maps to map genes for human complex disease. In some studies the number of genotypes…”
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Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits by Klein, Alison P, Tsai, Ya-Yu, Duggal, Priya, Gillanders, Elizabeth M, Barnhart, Michael, Mathias, Rasika A, Dusenberry, Ian P, Turiff, Amy, Chines, Peter S, Goldstein, Janet, Wojciechowski, Robert, Hening, Wayne, Pugh, Elizabeth W, Bailey-Wilson, Joan E

“…Genome-wide linkage analysis using microsatellite markers has been successful in the identification of numerous Mendelian and complex disease loci. The recent…”
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Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium by Duggal, Priya, Gillanders, Elizabeth M, Mathias, Rasika A, Ibay, Grace P, Klein, Alison P, Baffoe-Bonnie, Agnes B, Ou, Liang, Dusenberry, Ian P, Tsai, Ya-Yu, Chines, Peter S, Doan, Betty Q, Bailey-Wilson, Joan E

“…We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical…”
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