Search Results - "Chinery, R."

Transgenic Mice that Overexpress the Human Trefoil Peptide pS2 have an Increased Resistance to Intestinal Damage by Playford, R. J., Marchbank, T., Goodlad, R. A., Chinery, R. A., Poulsom, R., Hanby, A. M., Wright, N. A.

“…pS2 is a member of the trefoil peptide family, all of which are overexpressed at sites of gastrointestinal injury. We hypothesized that they are important in…”
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Intestinal Trefoil Factor Controls the Expression of the Adenomatous Polyposis Coli--Catenin and the E-Cadherin--Catenin Complexes in Human Colon Carcinoma Cells by Efstathiou, J. A., Noda, M., Rowan, A., Dixon, C., Chinery, R., Jawhari, A., Hattori, T., Wright, N. A., Bodmer, W. F., Pignatelli, M.

“…Intestinal trefoil factor 3 (TFF3) is a member of the trefoil family of peptides, small molecules constitutively expressed in epithelial tissues, including the…”
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Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat by Chinery, R, Playford, R J

“…1. The availability of recombinant epidermal growth factor provides a potentially exciting development for the treatment of gastrointestinal ulceration…”
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hP1.B, a Human P-Domain Peptide Homologous with Rat Intestinal Trefoil Factor, is Expressed Also in the Ulcer-Associated Cell Lineage and the Uterus by Hauser, Frank, Poulsom, Richard, Chinery, Rebecca, Rogers, Len A., Hanby, Andrew M., Wright, Nicholas A., Hoffmann, Werner

“…The six-cysteine P-domain motif forms the basic repeat unit of a growing family of mucin-associated peptides. A precursor for a human secretory polypeptide has…”
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Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract by Hanby, AM, Chinery, R, Poulsom, R, Playford, RJ, Pignatelli, M

“…E-cadherin, an epithelial adhesion molecule, is critical for the maintenance of cell polarity and differentiation. We studied the distribution of E-cadherin in…”
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Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor by Chinery, R., Cox, H.M.

“…1 The direct epithelial effects of epidermal growth factor (EGF) and its modulation by intestinal trefoil factor (ITF) have been studied in a human colonic…”
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The role of transforming growth factor alpha in the enterochromaffin- like cell tumor autonomy in an African rodent mastomys by Tang, LH, Modlin, IM, Lawton, GP, Kidd, M, Chinery, R

“…BACKGROUND & AIMS: Gastric carcinoids evolved from enterochromaffin- like (ECL) cell hyperplasia are usually associated with high pH and hypergastrinemia. The…”
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The Gene Encoding Human Intestinal Trefoil Factor (TFF3) Is Located on Chromosome 21q22.3 Clustered with Other Members of the Trefoil Peptide Family by Chinery, Rebecca, Williamson, Jill, Poulsom, Richard

“…The gene coding for human intestinal trefoil factor (hITF), a recently described cellular motogen produced by gastrointestinal goblet cells and epithelia…”
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Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution by Marchbank, T, Chinery, R, Hanby, AM, Poulsom, R, Elia, G, Playford, RJ

“…Pancreatic secretory trypsin inhibitor (PSTI) is a potent serine protease inhibitor that prevents excessive digestion of the gastrointestinal mucus but may…”
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8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo by Carlson, Chris C., Chinery, Rebecca, Burnham, Laura L., Dransfield, Daniel T.

“…The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little…”
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Trefoil Peptides: Less Clandestine in the Intestine by Chinery, Rebecca, Coffey, Robert J.

“…Trefoil peptides are small, stable peptides secreted into the gut, but their function has been obscure. Now Lefebvre et al . ( p. 259 ) and Mashimo et al . (…”
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Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization In situ by CHINERY, R, POULSOM, R, ROGERS, L. A, JEFFERY, R. E, LONGCROFT, J. M, HANBY, A. M, WRIGHT, N. A

“…A cDNA encoding rat intestinal trefoil factor (rITF) was prepared by reverse transcription and PCR amplification. The sequence obtained was well conserved with…”
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A compartmental model for the prediction of breath concentration and absorbed dose of chloroform after exposure while showering by Chinery, R L, Gleason, A K

“…In order to predict the exhaled breath concentration of chloroform in individuals exposed to chloroform while showering, an existing physiologically based…”
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Trefoil peptide expression in intestinal adaptation and renewal by Poulsom, R, Chinery, R, Sarraf, C, Lalani, E N, Stamp, G, Elia, G, Wright, N

“…There are many avenues where molecular biology is important in studying the gut, and here we explore methods for defining expression of a new gene family in…”
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Regulation of Mastomys ECL Cell Function by Transforming Growth Factor Alpha by Lawton, Gary P., Tang, Laura, Kidd, Mark, Chinery, Rebecca, Miu, Ken, Modlin, Irvin M.

“…Little progress has been made in the understanding of the pathobiology of gastric neoplasia over the past 4 decades. This reflects the paucity of information…”
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FasL is a β-catenin/TCF-4 target gene repressed by smads in RKO-1 colorectal cancer cells by CHINERY, R, WELLER, S

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Epidermal Growth Factor Receptor Activation Induces Nuclear Targeting of Cyclooxygenase-2, Basolateral Release of Prostaglandins, and Mitogenesis in Polarizing Colon Cancer Cells by Coffey, Robert J., Hawkey, Chris J., Damstrup, Lars, Graves-Deal, Ramona, Daniel, Vincent C., Dempsey, Peter J., Chinery, Rebecca, Kirkland, Susan C., DuBois, Raymond N., Jetton, Thomas L., Morrow, Jason D.

“…Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is…”
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Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins by Adler, Haskell T., Chinery, Rebecca, Wu, Daniel Y., Kussick, Steven J., Payne, John M., Fornace, Albert J., Tkachuk, Douglas C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration by Playford, R J, Marchbank, T, Chinery, R, Evison, R, Pignatelli, M, Boulton, R A, Thim, L, Hanby, A M

“…Gastric epithelium is attacked by acid, pepsin, and ingested agents. When a mucosal lesion occurs, the defect is rapidly closed by cell migration. Because…”
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Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells by CHINERY, R, BEAUCHAMP, R. D, SHYR, Y, KIRKLAND, S. C, COFFEY, R. J, MORROW, J. D

“…Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal…”
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