Search Results - "Chin, Yanni K Y"

Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
Get full text

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation by Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B., Mobli, Mehdi

“…Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights into channel structure and pharmacology…”
Get full text

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider by Finol-Urdaneta, Rocio K, Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R, Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K-Y, Wingerd, Joshua S, Undheim, Eivind A B, Cristofori-Armstrong, Ben, Hill, Adam P, Herzig, Volker, King, Glenn F, Vetter, Irina, Rash, Lachlan D, Adams, David J, Alewood, Paul F

“…The King Baboon spider, , is a burrowing African tarantula. Its impressive size and appealing coloration are tempered by reports describing severe localized…”
Get full text

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function by Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N., Zhao, Jing, Stehbens, Samantha J., Mobli, Mehdi, Leffler, Andreas, Jiang, Daohua, Cox, James J., Waxman, Stephen G., Dib-Hajj, Sulayman D., Neely, G. Gregory, Durek, Thomas, Vetter, Irina

“…Voltage-gated sodium (Na V ) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the…”
Get full text

Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation by Jia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J., Mobli, Mehdi

“…Macrocyclisation of proteins and peptides results in a remarkable increase in structural stability, making cyclic peptides and proteins of great interest in…”
Get full text

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity by Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K.-Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J., Rash, Lachlan D.

“…Voltage-gated sodium (Na V ) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new…”
Get full text

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a by Chassagnon, Irène R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D., King, Glenn F.

“…Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing…”
Get full text

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene by Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S., King, Glenn F.

“…Spiders are one of the most successful venomous animals, with more than 48,000 described species. Most spider venoms are dominated by cysteine-rich peptides…”
Get full text

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities by Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi, Collins, Brett M.

“…Phox homology (PX) domains are membrane interacting domains that bind to phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity…”
Get full text

The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides by Deplazes, Evelyne, Chin, Yanni K.‐Y., King, Glenn F., Mancera, Ricardo L.

“…The cross‐strand disulfides (CSDs) found in β‐hairpin antimicrobial peptides (β‐AMPs) show a unique disulfide geometry that is characterized by unusual torsion…”
Get full text

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides by Herzig, Volker, de Araujo, Aline Dantas, Greenwood, Kathryn P, Chin, Yanni K-Y, Windley, Monique J, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham M, Alewood, Paul F, King, Glenn F

“…Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about…”
Get full text

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals by Eagles, David A, Saez, Natalie J, Krishnarjuna, Bankala, Bradford, Julia J, Chin, Yanni K-Y, Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E, Undheim, Eivind A B, Norton, Raymond S, Thomas, Walter G, Vetter, Irina, King, Glenn F, Robinson, Samuel D

“…Venoms are excellent model systems for studying evolutionary processes associated with predator-prey interactions. Here, we present the discovery of a peptide…”
Get full text

Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2 by Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi, Strømgaard, Kristian

“…Peptides targeting disease-relevant protein–protein interactions are an attractive class of therapeutics covering the otherwise undruggable space between small…”
Get full text

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus by Touchard, Axel, Brust, Andreas, Cardoso, Fernanda Caldas, Chin, Yanni K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme, Escoubas, Pierre

“…Most ant venoms consist predominantly of small linear peptides, although some contain disulfide-linked peptides as minor components. However, in striking…”
Get full text

Cysteine-Rich α‑Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor by Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y, Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A, King, Glenn F, Lewis, Richard J, Adams, David J, Alewood, Paul F

“…α-Conotoxins that target muscle nicotinic acetylcholine receptors (nAChRs) commonly fall into two structural classes, frameworks I and II containing two and…”
Get full text

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs by Chow, Chun Yuen, Chin, Yanni K.-Y, Walker, Andrew A, Guo, Shaodong, Blomster, Linda V, Ward, Micaiah J, Herzig, Volker, Rokyta, Darin R, King, Glenn F

“…Voltage-gated sodium (NaV) channels play a fundamental role in normal neurological function, especially via the initiation and propagation of action…”
Get full text

The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor by Herzig, Volker, Chen, Yong-Cyuan, Chin, Yanni K.-Y., Dekan, Zoltan, Chang, Yu-Wang, Yu, Hui-Ming, Alewood, Paul F., Chen, Chien-Chang, King, Glenn F.

“…Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to cardiovascular and nerve systems. Further, knockout animal studies…”
Get full text

Structure and bioactivity of an insecticidal trans-defensin from assassin bug venom by Walker, Andrew A, Chin, Yanni K-Y, Guo, Shaodong, Jin, Jiayi, Wilbrink, Evienne, Goudarzi, Mohaddeseh Hedayati, Wirth, Hayden, Gordon, Eric, Weirauch, Christiane, King, Glenn F

“…Disulfide-rich peptides such as defensins play diverse roles in immunity and ion channel modulation, as well as constituting the bioactive components of many…”
Get more information

A selective NaV1.1 activator with potential for treatment of Dravet syndrome epilepsy by Chow, Chun Yuen, Chin, Yanni K.Y., Ma, Linlin, Undheim, Eivind A.B., Herzig, Volker, King, Glenn F.

“…[Display omitted] Dravet syndrome (DS) is a catastrophic epileptic encephalopathy characterised by childhood-onset polymorphic seizures, multiple…”
Get full text

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7 by Klint, Julie K, Chin, Yanni K-Y, Mobli, Mehdi

“…Many spider-venom peptides are known to modulate the activity of the voltage-gated sodium (NaV) subtype 1.7 (NaV1.7) channel, which has emerged as a promising…”
Get more information