Search Results - "Chin, Paulynn S"

Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth by Kellaway, Sophie G., Potluri, Sandeep, Keane, Peter, Blair, Helen J., Ames, Luke, Worker, Alice, Chin, Paulynn S., Ptasinska, Anetta, Derevyanko, Polina K., Adamo, Assunta, Coleman, Daniel J. L., Khan, Naeem, Assi, Salam A., Krippner-Heidenreich, Anja, Raghavan, Manoj, Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze

“…Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene…”
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Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1 by Potluri, Sandeep, Assi, Salam A., Chin, Paulynn S., Coleman, Dan J.L., Pickin, Anna, Moriya, Shogo, Seki, Naohiko, Heidenreich, Olaf, Cockerill, Peter N., Bonifer, Constanze

“…Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor…”
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Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth by Coleman, Daniel J.L., Keane, Peter, Luque-Martin, Rosario, Chin, Paulynn S., Blair, Helen, Ames, Luke, Kellaway, Sophie G., Griffin, James, Holmes, Elizabeth, Potluri, Sandeep, Assi, Salam A., Bushweller, John, Heidenreich, Olaf, Cockerill, Peter N., Bonifer, Constanze

“…Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific…”
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t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming by Kellaway, Sophie, Chin, Paulynn S, Barneh, Farnaz, Bonifer, Constanze, Heidenreich, Olaf

“…Acute myeloid leukemia (AML) is a heterogenous disease with multiple sub-types which are defined by different somatic mutations that cause blood cell…”
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Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1 by Coleman, Daniel J.L., Keane, Peter, Chin, Paulynn S., Ames, Luke, Kellaway, Sophie, Blair, Helen, Khan, Naeem, Griffin, James, Holmes, Elizabeth, Maytum, Alexander, Potluri, Sandeep, Strate, Lara, Koscielniak, Kinga, Raghavan, Manoj, Bushweller, John, Heidenreich, Olaf, Rabbitts, Terry, Cockerill, Peter N., Bonifer, Constanze

“…AML is characterized by mutations in genes associated with growth regulation such as internal tandem duplications (ITD) in the receptor kinase FLT3. Inhibitors…”
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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia by Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, Bomken, Simon

“…•Myeloid relapse can originate from various differentiation stages of MLL/AF4+ ALL.•Dysregulation of epigenetic regulators underpins fundamental lineage…”
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A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program by Lin, Shan, Ptasinska, Anetta, Chen, Xiaoting, Shrestha, Mahesh, Assi, Salam A., Chin, Paulynn S., Imperato, Maria R., Aronow, B.J., Zhang, Jingsong, Weirauch, Matthew T., Bonifer, Constanze, Mulloy, James C.

“…Understanding and blocking the self-renewal pathway of preleukemia stem cells could prevent acute myeloid leukemia (AML) relapse. In this study, we show that…”
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