Search Results - "Chin, Michael"

Basic mechanisms for adverse cardiovascular events associated with air pollution by Chin, Michael T

“…Air pollution is a significant cause of cardiovascular morbidity and mortality worldwide. Although the epidemiologic association between air pollution…”
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Intracellular Delivery of Proteins with Cell-Penetrating Peptides for Therapeutic Uses in Human Disease by Dinca, Ana, Chien, Wei-Ming, Chin, Michael T

“…Protein therapy exhibits several advantages over small molecule drugs and is increasingly being developed for the treatment of disorders ranging from single…”
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Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450 by Zhou, Qi, Chin, Michael, Fu, Yue, Liu, Peng, Yang, Yang

“…Naturally occurring enzymes can be a source of unnatural reactivity that can be molded by directed evolution to generate efficient biocatalysts with valuable…”
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The UCR time series archive by Dau, Hoang Anh, Bagnall, Anthony, Kamgar, Kaveh, Yeh, Chin-Chia Michael, Zhu, Yan, Gharghabi, Shaghayegh, Ratanamahatana, Chotirat Ann, Keogh, Eamonn

“…The UCR time series archive–introduced in 2002, has become an important resource in the time series data mining community, with at least one thousand published…”
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Pathogenic Mechanisms of Hypertrophic Cardiomyopathy beyond Sarcomere Dysfunction by Chou, Chun, Chin, Michael T.

“…Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, affecting 1 in 500 people in the general population. Although…”
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Role of the Alpha-B-Crystallin Protein in Cardiomyopathic Disease by Thorkelsson, Andres, Chin, Michael T

“…Alpha-B-crystallin, a member of the small heat shock family of proteins, has been implicated in a variety of cardiomyopathies and in normal cardiac…”
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In utero exposure to diesel exhaust air pollution promotes adverse intrauterine conditions, resulting in weight gain, altered blood pressure, and increased susceptibility to heart failure in adult mice by Weldy, Chad S, Liu, Yonggang, Liggitt, H Denny, Chin, Michael T

“…Exposure to fine particulate air pollution (PM₂.₅) is strongly associated with cardiovascular morbidity and mortality. Exposure to PM₂.₅ during pregnancy…”
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Common and Distinctive Intercellular Communication Patterns in Human Obstructive and Nonobstructive Hypertrophic Cardiomyopathy by Codden, Christina J, Chin, Michael T

“…Hypertrophic Cardiomyopathy (HCM) is a common inherited disorder characterized by unexplained left ventricular hypertrophy with or without left ventricular…”
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A method for cryopreservation and single nucleus RNA-sequencing of normal adult human interventricular septum heart tissue reveals cellular diversity and function by Larson, Amy, Chin, Michael T

“…Single cell sequencing of human heart tissue is technically challenging and methods to cryopreserve heart tissue for obtaining single cell information have not…”
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Visual Analytics for RNN-Based Deep Reinforcement Learning by Wang, Junpeng, Zhang, Wei, Yang, Hao, Yeh, Chin-Chia Michael, Wang, Liang

“…Deep reinforcement learning (DRL) targets to train an autonomous agent to interact with a pre-defined environment and strives to achieve specific goals through…”
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Discussion: Creating a Favorable Microenvironment for Fat Grafting in a Novel Model of Radiation-Induced Mammary Fat Pad Fibrosis by Lujan-Hernandez, Jorge, Chin, Michael S.

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Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular Communication by Perera, Gayani, Power, Liam, Larson, Amy, Codden, Christina J, Awata, Junya, Batorsky, Rebecca, Strathdee, Douglas, Chin, Michael T

“…Barth Syndrome, a rare X-linked disorder affecting 1:300,000 live births, results from defects in Tafazzin, an acyltransferase that remodels cardiolipin and is…”
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Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab by Chin, S. Michael, Kimberlin, Christopher R., Roe-Zurz, Zygy, Zhang, Pamela, Xu, Allison, Liao-Chan, Sindy, Sen, Debasish, Nager, Andrew R., Oakdale, Nicole Schirle, Brown, Colleen, Wang, Feng, Yang, Yuting, Lindquist, Kevin, Yeung, Yik Andy, Salek-Ardakani, Shahram, Chaparro-Riggers, Javier

“…4-1BB ( CD137 , TNFRSF9 ) is an inducible costimulatory receptor expressed on activated T cells. Clinical trials of two agonist antibodies, utomilumab…”
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Financial market Volatility, macroeconomic fundamentals and investor Sentiment by (Jeremy) Chiu, Ching-wai, Harris, Richard D.F., Stoja, Evarist, Chin, Michael

“…•We investigate the relationship between financial volatility and the real economy.•Adverse shocks to aggregate demand and supply increase persistent…”
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Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling by Moore, Jarrod, Ewoldt, Jourdan, Venturini, Gabriela, Pereira, Alexandre C, Padilha, Kallyandra, Lawton, Matthew, Lin, Weiwei, Goel, Raghuveera, Luptak, Ivan, Perissi, Valentina, Seidman, Christine E, Seidman, Jonathan, Chin, Michael T, Chen, Christopher, Emili, Andrew

“…Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a leading cause of sudden cardiac death in young adults. Despite profound…”
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Learning-From-Disagreement: A Model Comparison and Visual Analytics Framework by Wang, Junpeng, Wang, Liang, Zheng, Yan, Yeh, Chin-Chia Michael, Jain, Shubham, Zhang, Wei

“…With the fast-growing number of classification models being produced every day, numerous model interpretation and comparison solutions have also been…”
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Time series joins, motifs, discords and shapelets: a unifying view that exploits the matrix profile by Yeh, Chin-Chia Michael, Zhu, Yan, Ulanova, Liudmila, Begum, Nurjahan, Ding, Yifei, Dau, Hoang Anh, Zimmerman, Zachary, Silva, Diego Furtado, Mueen, Abdullah, Keogh, Eamonn

“…The last decade has seen a flurry of research on all-pairs-similarity-search (or similarity joins ) for text, DNA and a handful of other datatypes, and these…”
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Is There an Optimal Autonomic State for Enhanced Flow and Executive Task Performance? by Chin, Michael S, Kales, Stefanos N

“…Flow describes a state of optimal experience that can promote a positive adaptation to increasing stress. The aim of the current study is to identify the ideal…”
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Spatial Transcriptomic Analysis of Focal and Normal Areas of Myocyte Disarray in Human Hypertrophic Cardiomyopathy by Laird, Jason, Perera, Gayani, Batorsky, Rebecca, Wang, Hongjie, Arkun, Knarik, Chin, Michael T

“…Hypertrophic Cardiomyopathy (HCM) is a common inherited disorder that can lead to heart failure and sudden cardiac death, characterized at the histological…”
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Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering by Ding, Kerr, Chin, Michael, Zhao, Yunlong, Huang, Wei, Mai, Binh Khanh, Wang, Huanan, Liu, Peng, Yang, Yang, Luo, Yunan

“…The effective design of combinatorial libraries to balance fitness and diversity facilitates the engineering of useful enzyme functions, particularly those…”
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