Search Results - "Chin, Mei Yieng"

Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion by Armstrong, Heather K., Gillis, Joanna L., Johnson, Ian R. D., Nassar, Zeyad D., Moldovan, Max, Levrier, Claire, Sadowski, Martin C., Chin, Mei Yieng, Tomlinson Guns, Emma S., Tarulli, Gerard, Lynn, David J., Brooks, Douglas A., Selth, Luke A., Centenera, Margaret M., Butler, Lisa M.

“…The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple…”
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Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes by Kharmate, Geetanjali, Hosseini-Beheshti, Elham, Caradec, Josselin, Chin, Mei Yieng, Tomlinson Guns, Emma S

“…Exosomes proteins and microRNAs have gained much attention as diagnostic tools and biomarker potential in various malignancies including prostate cancer (PCa)…”
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Steroidogenesis in Peripheral and Transition Zones of Human Prostate Cancer Tissue by Deb, Subrata, Chin, Mei Yieng, Pham, Steven, Adomat, Hans, Hurtado-Coll, Antonio, Gleave, Martin E, Tomlinson Guns, Emma S

“…The peripheral zone (PZ) and transition zone (TZ) represent about 70% of the human prostate gland with each zone having differential ability to develop…”
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A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice by Fokidis, H. Bobby, Yieng Chin, Mei, Ho, Victor W., Adomat, Hans H., Soma, Kiran K., Fazli, Ladan, Nip, Ka Mun, Cox, Michael, Krystal, Gerald, Zoubeidi, Amina, Tomlinson Guns, Emma S.

“…•A low carbohydrate diet, compared to a typical Western diet, inhibits PCa tumor growth in vivo in mice.•LNCaP xenograft tumor growth was studied in both…”
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Correction: Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes by Kharmate, Geetanjali, Hosseini-Beheshti, Elham, Caradec, Josselin, Chin, Mei Yieng, Tomlinson Guns, Emma S

“…[This corrects the article DOI: 10.1371/journal.pone.0154967.]…”
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Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models by Deb, Subrata, Pham, Steven, Ming, Dong-Sheng, Chin, Mei Yieng, Adomat, Hans, Hurtado-Coll, Antonio, Gleave, Martin E, Guns, Emma S Tomlinson

“…Castration-resistant prostate tumors acquire the independent capacity to generate androgens by upregulating steroidogenic enzymes or using steroid precursors…”
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The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation by Wang, Jing, Chin, Mei Yieng, Li, Gang

“…p33ING2 is a novel candidate tumor suppressor, which has been shown to be involved in the regulation of gene transcription, cell cycle arrest, and apoptosis in…”
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Anti-Tumor Effects of Ginsenoside 20(S)-Protopanaxadiol and 1,25-Dihydroxyvitamin D3 Combination in Castration Resistant Prostate Cancer by Ben-Eltriki, Mohamed, Deb, Subrata, Shankar, Gehana, Meckling, Gray, Hassona, Mohamed, Yamazaki, Takeshi, Fazli, Ladan, Chin, Mei Yieng, Tomlinson Guns, Emma S.

“…In spite of possessing desirable anticancer properties, currently, limited clinical success has been achieved with 20(S)-protopanaxadiol (aPPD) and…”
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Tissue-specific regulation of checkpoint kinase 2 expression by p53 by Chin, Mei Yieng, Li, Gang

“…Chk2 (Checkpoint kinase 2) is emerging as a critical mediator of genotoxic stress and diverse cellular responses. Upon ionizing radiation, Chk2 is activated to…”
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Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment by Hosseini-Beheshti, Elham, Choi, Wendy, Weiswald, Louis-Bastien, Kharmate, Geetanjali, Ghaffari, Mazyar, Roshan-Moniri, Mani, Hassona, Mohamed D, Chan, Leslie, Chin, Mei Yieng, Tai, Isabella T, Rennie, Paul S, Fazli, Ladan, Tomlinson Guns, Emma S

“…Prostate cancer (PCa) is the most frequently diagnosed cancer in men. Current research on tumour-related extracellular vesicles (EVs) suggests that exosomes…”
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Steroid Metabolism in Human Prostate Cancer Tissue: Effect of CYP17 Inhibitors by Deb, Subrata, Chin, Mei Yieng, Pham, Steven, Adomat, Hans, Hurtado‐Coll, Antonio, Gleave, Martin, Tomlinson Guns, Emma S.

“…Abstract only De novo steroidogenesis is a mechanism that develops during castration‐resistant prostate cancer (CRPC). There is increasing evidence of…”
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Comparing the efficiency of exosomes isolation from prostate and pancreatic cancer cell lines using size exclusion chromatography and ExoQuick-TC by Chin, Mei Yieng, Guns, Emma, Kalra, Jessica

“…Background: Both prostate cancer (PCa) and pancreatic ductal adenocarcinoma (PDAC) continue to demonstrate poor outcomes due to late stage diagnosis. Research…”
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Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro by Deb, Subrata, Chin, Mei Yieng, Adomat, Hans, Guns, Emma S. Tomlinson

“…•Abiraterone is a newly approved drug used for prostate cancer treatment.•Abiraterone inhibits human CYP3A4-mediated inactivation of 1α,25-dihydroxyvitamin…”
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Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo by Ming, Dong-Sheng, Pham, Steven, Deb, Subrata, Chin, Mei Yieng, Kharmate, Geetanjali, Adomat, Hans, Beheshti, Elham Hosseini, Locke, Jennifer, Guns, Emma Tomlinson

“…Castration-resistant prostate cancer (CRPC) remains largely dependent on androgen receptor (AR). Residual tissue androgens are consistently detected within…”
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20(S)-protopanaxadiol regio-selectively targets androgen receptor: anticancer effects in castration-resistant prostate tumors by Ben-Eltriki, Mohamed, Deb, Subrata, Hassona, Mohamed, Meckling, Gray, Fazli, Ladan, Chin, Mei Yieng, Lallous, Nada, Yamazaki, Takeshi, Jia, William, Rennie, Paul S, Cherkasov, Artem, Tomlinson Guns, Emma S

“…We have explored the effects of 20(S)-protopanaxadiol (aPPD), a naturally derived ginsenoside, against androgen receptor (AR) positive castration resistant…”
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Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro by Deb, Subrata, Chin, Mei Yieng, Adomat, Hans, Guns, Emma S. Tomlinson

“…•Vitamin D and ginsenosides have common disease targets, e.g. cancer, metabolic syndrome and neurodegenerative diseases.•Ginsenosides attenuate human…”
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The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells by Chin, Mei Yieng, Ng, Kin Cheung P., Li, Gang

“…The roles of p33 ING2 as a tumor suppressor candidate have been shown through regulation of gene transcription, induction of cell cycle arrest, and apoptosis…”
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The novel tumor suppressor p331NG2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation by JING WANG, MEI YIENG CHIN, GANG LI

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