Search Results - "Chin, Harvey F."

Mechanism of Cytokinetic Contractile Ring Constriction in Fission Yeast by Stachowiak, Matthew R., Laplante, Caroline, Chin, Harvey F., Guirao, Boris, Karatekin, Erdem, Pollard, Thomas D., O’Shaughnessy, Ben

“…Cytokinesis involves constriction of a contractile actomyosin ring. The mechanisms generating ring tension and setting the constriction rate remain unknown…”
Get full text

Actin Network Architecture Can Determine Myosin Motor Activity by Reymann, Anne-Cécile, Boujemaa-Paterski, Rajaa, Martiel, Jean-Louis, Guérin, Christophe, Cao, Wenxiang, Chin, Harvey F., De La Cruz, Enrique M., Théry, Manuel, Blanchoin, Laurent

“…The organization of actin filaments into higher-ordered structures governs eukaryotic cell shape and movement. Global actin network size and architecture are…”
Get full text

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S] by Singh, Rajesh K., Haka, Abigail S., Brumfield, Alexandria, Grosheva, Inna, Bhardwaj, Priya, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.

“…Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes…”
Get full text

The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes by Cai, Yiying, Chin, Harvey F., Lazarova, Darina, Menon, Shekar, Fu, Chunmei, Cai, Huaqing, Sclafani, Anthony, Rodgers, David W., De La Cruz, Enrique M., Ferro-Novick, Susan, Reinisch, Karin M.

“…The multimeric membrane-tethering complexes TRAPPI and TRAPPII share seven subunits, of which four (Bet3p, Bet5p, Trs23p, and Trs31p) are minimally needed to…”
Get full text

STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC by Garbarino, Jeanne, Pan, Meihui, Chin, Harvey F., Lund, Frederik W., Maxfield, Frederick R., Breslow, Jan L.

“…STARD4, a member of the evolutionarily conserved START gene family, has been implicated in the nonvesicular intracellular transport of cholesterol. However,…”
Get full text

Myosin Isoform Determines the Conformational Dynamics and Cooperativity of Actin Filaments in the Strongly Bound Actomyosin Complex by Prochniewicz, Ewa, Chin, Harvey F., Henn, Arnon, Hannemann, Diane E., Olivares, Adrian O., Thomas, David D., De La Cruz, Enrique M.

“…We used transient phosphorescence anisotropy to detect the microsecond rotational dynamics of erythrosin-iodoacetamide-labeled actin strongly bound to…”
Get full text

Direct observation of the myosin Va recovery stroke that contributes to unidirectional stepping along actin by Shiroguchi, Katsuyuki, Chin, Harvey F, Hannemann, Diane E, Muneyuki, Eiro, De La Cruz, Enrique M, Kinosita, Jr, Kazuhiko

“…Myosins are ATP-driven linear molecular motors that work as cellular force generators, transporters, and force sensors. These functions are driven by…”
Get full text

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates by Singh, Rajesh K., Haka, Abigail S., Asmal, Arky, Barbosa-Lorenzi, Valéria C., Grosheva, Inna, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.

“…OBJECTIVE:Aggregation and modification of LDLs (low-density lipoproteins) promote their retention and accumulation in the arteries. This is a critical…”
Get full text

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation by Haka, Abigail S, Singh, Rajesh K, Grosheva, Inna, Hoffner, Haley, Capetillo-Zarate, Estibaliz, Chin, Harvey F, Anandasabapathy, Niroshana, Maxfield, Frederick R

“…Although dendritic cells are known to play a role in atherosclerosis, few studies have examined the contribution of the wide variety of dendritic cell subsets…”
Get full text

Myosin V Inhibitor Based on Privileged Chemical Scaffolds by Islam, Kabirul, Chin, Harvey F, Olivares, Adrian O, Saunders, Lauren P, De La Cruz, Enrique M, Kapoor, Tarun M

“…Switching the motor off: Privileged chemical scaffolds were used as a starting point for the development of a specific chemical inhibitor 1 of myosin V, a key…”
Get full text

Actin Filament Dynamics in the Actomyosin VI Complex Is Regulated Allosterically by Calcium–Calmodulin Light Chain by Prochniewicz, Ewa, Pierre, Anaëlle, McCullough, Brannon R., Chin, Harvey F., Cao, Wenxiang, Saunders, Lauren P., Thomas, David D., De La Cruz, Enrique M.

“…The contractile and enzymatic activities of myosin VI are regulated by calcium binding to associated calmodulin (CaM) light chains. We have used transient…”
Get full text

Kinetic Analysis of the Guanine Nucleotide Exchange Activity of TRAPP, a Multimeric Ypt1p Exchange Factor by Chin, Harvey F., Cai, Yiying, Menon, Shekar, Ferro-Novick, Susan, Reinisch, Karin M., De La Cruz, Enrique M.

“…TRAPP complexes, which are large multimeric assemblies that function in membrane traffic, are guanine nucleotide exchange factors (GEFs) that activate the Rab…”
Get full text

TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates by Singh, Rajesh K., Haka, Abigail S., Asmal, Arky, Barbosa-Lorenzi, Valéria C., Grosheva, Inna, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.

Get full text

Measurements and Simulations of the Fission Yeast Cytokinetic Ring Tension during Constriction by Chin, Harvey F., Karatekin, Erdem, Pollard, Thomas D., O'shaughnessy, Ben

Get full text

Two Isoforms of Myosin-II Account for the Tension of the Fission Yeast Cytokinetic Ring by Wang, Shuyuan, Chin, Harvey F., Karatekin, Erdem, Pollard, Thomas D., O'Shaughnessy, Ben

Get full text

Abstract 570: Macrophage Catabolism of Aggregated Lipoproteins Using a Novel Extracellular Compartment Regulates Lipid Accumulation During Atherosclerosis by Singh, Rajesh K, Haka, Abigail S, Barbosa-Lorenzi, Valeria C, Asmal, Arky, Lund, Frederik, Xiong, Yuquan, Chin, Harvey F, Grosheva, Inna, Hla, Timothy, Maxfield, Frederick R

“…Abstract only Despite impressive advances in research, prevention, and treatment, atherosclerotic vascular disease remains the leading cause of death in the…”
Get full text

Macrophage catabolism of aggregated lipoproteins using a novel extracellular compartment regulates lipid accumulation during atherosclerosis by Singh, Rajesh K, Haka, Abigail S, Barbosa‐Lorenzi, Valeria C, Asmal, Arky, Lund, Frederik, Xiong, Yuquan, Chin, Harvey F, Grosheva, Inna, Hla, Timothy, Maxfield, Frederick R

“…Abstract only Despite impressive advances in research, prevention, and treatment, atherosclerotic vascular disease remains the leading cause of death in the…”
Get full text

Abstract 497: Cholesterol and Toll-like Receptor Signaling Are Important Regulators of Macrophage Interactions with Atherosclerotic Lipoprotein Aggregates by Chin, Harvey F, Haka, Abigail, Maxfield, Frederick R

“…Abstract only Macrophages encounter deposits of aggregated low-density lipoproteins (agLDL) in the subendothelial space of blood vessels during the first…”
Get full text

Experimental Measurement and Simulations of the Cytokinetic Ring Tension in Fission Yeast by Chin, Harvey F., Stachowiak, Matthew R., Laplante, Caroline, Karatekin, Erdem, Pollard, Thomas D., O'Shaughnessy, Ben

Get full text

Monocyte-derived dendritic cells upregulate extracellular catabolism of aggregated LDL upon maturation, leading to foam cell formation by Haka, Abigail S., Singh, Rajesh K., Grosheva, Inna, Hoffner, Haley, Capetillo-Zarate, Estibaliz, Chin, Harvey F., Anandasabapathy, Niroshana, Maxfield, Frederick R.

Get full text