value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection

value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection

Acute rejection remains a poor predictor of graft outcome. In this study, we measured serum levels of interferon (IFN)-γ and neopterin by enzyme-linked immunosorbent assay and a single nucleotide polymorphism (SNP) within the 3' untranslated region of the interleukin (IL)-12 B gene (1188 A/C) t...

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Bibliographic Details
Published in:Clinical and experimental immunology Vol. 152; no. 2; pp. 239 - 244
Main Authors: Chin, G.K, Adams, C.L, Carey, B.S, Shaw, S, Tse, W.-Y, Kaminski, E.R
Format: Journal Article
Language:English
Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-05-2008
Blackwell Publishing Ltd
Blackwell
Blackwell Science Inc
Subjects:
Acute Disease
acute renal allograft rejection
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers - blood
Female
Fundamental and applied biological sciences. Psychology
Graft Rejection - diagnosis
Graft Rejection - genetics
Graft Rejection - immunology
Humans
IFN-γ
IL-12 genetic polymorphisms
Interferon-gamma - blood
Interleukin-12 Subunit p40 - genetics
Kidney Transplantation - immunology
Male
Middle Aged
neopterin
Neopterin - blood
Polymerase Chain Reaction - methods
Polymorphism, Single Nucleotide
Prognosis
Retrospective Studies
Translational Studies
acute renal allograft rejection
Acute
Cytokine
Homograft
Interleukin 12
Biochemistry
IL-12 genetic polymorphisms
neopterin
Kidney
Rejection
IFN-γ
Urinary system
Graft
Genetics
Serum
Gamma interferon
Polymorphism
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Summary:Acute rejection remains a poor predictor of graft outcome. In this study, we measured serum levels of interferon (IFN)-γ and neopterin by enzyme-linked immunosorbent assay and a single nucleotide polymorphism (SNP) within the 3' untranslated region of the interleukin (IL)-12 B gene (1188 A/C) to determine whether either of these factors could predict acute rejection in renal transplantation. Significantly higher early post-transplant neopterin levels (days 5-7; 35·7 versus 19·9 nmol/l) were observed in recipients who subsequently rejected their grafts. Post-transplant neopterin levels showed a strong positive correlation with 1-month creatinine levels (Spearman's correlation 0·62, P < 0·001), suggesting macrophage activation early after transplantation. Pretransplant neopterin and IFN-γ levels and the IL-12B gene SNP did not predict acute rejection in this small retrospective study. The ability to predict acute rejection non-invasively early after transplantation could lead to individual tailoring of immunosuppressive regimens and perhaps lead eventually to longer graft survival.
Bibliography:http://dx.doi.org/10.1111/j.1365-2249.2008.03632.x
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2008.03632.x