Search Results - "Chin, David Y."

Targeting membrane proteins for antibody discovery using phage display by Jones, Martina L., Alfaleh, Mohamed A., Kumble, Sumukh, Zhang, Shuo, Osborne, Geoffrey W., Yeh, Michael, Arora, Neetika, Hou, Jeff Jia Cheng, Howard, Christopher B., Chin, David Y., Mahler, Stephen M.

“…A critical factor in the successful isolation of new antibodies by phage display is the presentation of a correctly folded antigen. While this is relatively…”
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Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates by Munro, Trent P., Mahler, Stephen M., Huang, Edwin P., Chin, David Y., Gray, Peter P.

“…Therapeutic monoclonal antibodies (mAbs) currently dominate the biologics marketplace. Development of a new therapeutic mAb candidate is a complex, multistep…”
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Functional gains in energy and cell metabolism after TSPO gene insertion by Liu, Guo-Jun, Middleton, Ryan J, Kam, Winnie Wai-Ying, Chin, David Y, Hatty, Claire R, Chan, Ronald H Y, Banati, Richard B

“…Recent loss-of-function studies in tissue-specific as well as global Tspo (Translocator Protein 18 kDa) knockout mice have not confirmed its long assumed…”
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Beyond Antibodies: Development of a Novel Protein Scaffold Based on Human Chaperonin 10 by Alsultan, Abdulkarim M., Chin, David Y., Howard, Christopher B., de Bakker, Christopher J., Jones, Martina L., Mahler, Stephen M.

“…Human Chaperonin 10 (hCpn10) was utilised as a novel scaffold for presenting peptides of therapeutic and diagnostic significance. Molecular dynamic simulations…”
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A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies by Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P., Munro, Trent P.

“…Recombinant monoclonal antibodies currently dominate the protein biologics marketplace. The path from target antigen discovery and screening, to a recombinant…”
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Production and characterisation of recombinant human chaperonin 10 for treatment of inflammatory disease by Naylor, Dean J., Hunt, Ben, Guidolin, Angelo, Hey, Allan W., Bastiras, Stan, de Bakker, Christopher J., Chin, David Y., Marquis, Christopher P., Lambert, Daniel, Howard, Christopher B., Dobbin, Caroline A., Mahler, Stephen M.

“…•Production of a novel protein based therapeutic for treating inflammatory diseases.•Process productivity improved using specific host strain and gene promoter…”
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Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening by Song, Michael, Raphaelli, Kristin, Jones, Martina L., Aliabadi-Zadeh, Khosrow, Leung, Kar Man, Crowley, David, Hughes, Benjamin, Mahler, Stephen, Gray, Peter P., Huang, Edwin P., Chin, David Y.

“…BACKGROUND: Human embryonic kidney‐293 (HEK‐293) cells are commonly used as a transient expression host but their application in stable therapeutic protein…”
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Cytotoxic Activity of CD48 Monoclonal Antibodies Against Human Lymphoma Cells by Wei, Jiewei, Chin, David Y., Mahler, Stephen M.

“…CD48 is a cell surface, glycosylphosphatidylinositol-linked glycoprotein, and a potential target for treatment of leukemia and lymphoma. Two anti-CD48 mAbs,…”
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Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology by Catzel, Dallia, Chin, David Y., Stanton, Peter G., Gray, Peter P., Mahler, Stephen M.

“…Complex glycoprotein biopharmaceuticals, such as follicle stimulating hormone (FSH), erythropoietin and tissue plasminogen activator consist of a range of…”
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Expression and characterisation of recombinant human CD48 and isolation of a human anti-CD48 monoclonal antibody by phage display by Wei, Jiewei, Chin, David Y, Catzel, Dallia, Pera, Natasha, Mahler, Stephen M

“…Human CD48, a membrane‐bound, glycosylphosphatidylinositol (GPI)‐linked glycoprotein, is a potential tumour target for the treatment of leukaemias and…”
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The Application of Emerging Technologies in Genomics and Proteomics to Drug Development by Mahler, Stephen M, Chin, David Y, Van Dyk, Derek D

“…The completion of the first draft of the Human Genome Project and the emerging discipline of proteomics will have a major impact on the future and practice of…”
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Hybrid therapy for Helicobacter pylori infection:A systemic review and meta-analysis by Hsu, Ping-I, Lin, Pei-Chin, Graham, David Y

“…AIM: To compare the effectiveness of hybrid therapy with other recommended regimens using metaanalysis.METHODS: Bibliographical searches for randomized trials…”
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Improved Protein-A separation of VH3 Fab from Fc after Papain Digestion of Antibodies by Seldon, Therese A., Hughes, Karen E., Munster, David J., Chin, David Y., Jones, Martina L.

“…Antibody-binding fragments (Fab) are generated from whole antibodies by treatment with papain and can be separated from the Fc component using Protein-A…”
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Improved Protein-A separation of V(H)3 Fab from Fc after papain digestion of antibodies by Seldon, Therese A, Hughes, Karen E, Munster, David J, Chin, David Y, Jones, Martina L

“…Antibody-binding fragments (Fab) are generated from whole antibodies by treatment with papain and can be separated from the Fc component using Protein-A…”
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Functional gains in energy and cell metabolism after TSPO gene insertion by Liu, Guo-Jun, Middleton, Ryan J., Kam, Winnie Wai-Ying, Chin, David Y., Hatty, Claire R., Chan, Ronald H. Y., Banati, Richard B.

“…Recent loss-of-function studies in tissue-specific as well as global Tspo (Translocator Protein 18 kDa) knockout mice have not confirmed its long assumed…”
Get full text