Search Results - "Chimote, Ameet A."

Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19 by Chimote, Ameet A, Alshwimi, Abdulaziz O, Chirra, Martina, Gawali, Vaibhavkumar S, Powers-Fletcher, Margaret V, Hudock, Kristin M, Conforti, Laura

“…Severe COVID-19 is characterized by cytokine storm, an excessive production of proinflammatory cytokines that contributes to acute lung damage and death…”
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KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells by Kuras, Zerrin, Yun, Yeo-Heung, Chimote, Ameet A, Neumeier, Lisa, Conforti, Laura

“…The migration of T lymphocytes is an essential part of the adaptive immune response as T cells circulate around the body to carry out immune surveillance…”
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A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8 + T Cells in Head and Neck Cancer by Chimote, Ameet A, Gawali, Vaibhavkumar S, Newton, Hannah S, Wise-Draper, Trisha M, Conforti, Laura

“…The limited ability of cytotoxic CD8 T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective…”
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Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients by Gawali, Vaibhavkumar S., Chimote, Ameet A., Newton, Hannah S., Feria-Garzón, Manuel G., Chirra, Martina, Janssen, Edith M., Wise-Draper, Trisha M., Conforti, Laura

“…Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC)…”
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Targeted knockdown of the adenosine A2A receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells by Newton, Hannah S., Chimote, Ameet A., Arnold, Michael J., Wise-Draper, Trisha M., Conforti, Laura

“…In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor,…”
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Disruption of Kv1.3 Channel Forward Vesicular Trafficking by Hypoxia in Human T Lymphocytes by Chimote, Ameet A., Kuras, Zerrin, Conforti, Laura

“…Hypoxia in solid tumors contributes to decreased immunosurveillance via down-regulation of Kv1.3 channels in T lymphocytes and associated T cell function…”
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Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer by Chimote, Ameet A, Hajdu, Peter, Sfyris, Alexandros M, Gleich, Brittany N, Wise-Draper, Trisha, Casper, Keith A, Conforti, Laura

“…Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8 T-cell effector…”
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Implementing Research Shared (Core) Facility Billing Systems by Chimote, Ameet A, Mayhew, Christopher, Thornton, Sherry, Wetzel, Cynthia, White, Amanda N

“…Research Shared (core) Facilities (RSF) operate as centers of expertise and help to accelerate basic and translational science. A centralized platform for…”
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Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells by Chimote, Ameet A, Hajdu, Peter, Kucher, Vladimir, Boiko, Nina, Kuras, Zerrin, Szilagyi, Orsolya, Yun, Yeo-Heung, Conforti, Laura

“…Adenosine, a purine nucleoside, is present at high concentrations in tumors, where it contributes to the failure of immune cells to eliminate cancer cells. The…”
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The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin by Hajdu, Peter, Martin, Geoffrey V, Chimote, Ameet A, Szilagyi, Orsolya, Takimoto, Koichi, Conforti, Laura

“…Kv1.3 channels play a pivotal role in the activation and migration of T-lymphocytes. These functions are accompanied by the channels' polarization, which is…”
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How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity by Chirra, Martina, Newton, Hannah S., Gawali, Vaibhavkumar S., Wise-Draper, Trisha M., Chimote, Ameet A., Conforti, Laura

“…Competent antitumor immune cells are fundamental for tumor surveillance and combating active cancers. Once established, tumors generate a tumor…”
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Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma by Chimote, Ameet A, Lehn, Maria A, Bhati, Jay, Mascia, Anthony E, Sertorio, Mathieu, Lamba, Michael A, Ionascu, Dan, Tang, Alice L, Langevin, Scott M, Khodoun, Marat V, Wise-Draper, Trisha M, Conforti, Laura

“…Proton therapy (PT) is emerging as an effective and less toxic alternative to conventional X-ray-based photon therapy (XRT) for patients with advanced head and…”
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Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity by Hajdu, Péter, Chimote, Ameet A, Thompson, Tyler H, Koo, Youngmi, Yun, Yeoheung, Conforti, Laura

“…Abstract Effector memory T cells (TM ) play a key role in the pathology of certain autoimmune disorders. The activity of effector TM cells is under the control…”
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Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype by Chimote, Ameet A, Hajdu, Peter, Kottyan, Leah C, Harley, John B, Yun, Yeoheung, Conforti, Laura

“…Abstract Ca2+ signaling controls activation and effector functions of T lymphocytes. Ca2+ levels also regulate NFAT activation and CD40 ligand (CD40L)…”
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Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus by Khodoun, Marat, Chimote, Ameet A, Ilyas, Farhan Z, Duncan, Heather J, Moncrieffe, Halima, Kant, K Shashi, Conforti, Laura

“…Lupus nephritis (LN) is an autoimmune disease with substantial morbidity/mortality and limited efficacy of available therapies. Memory T (Tm) lymphocytes…”
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PD1 blockade enhances K + channel activity, Ca 2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer by Newton, Hannah S, Gawali, Vaibhavkumar S, Chimote, Ameet A, Lehn, Maria A, Palackdharry, Sarah M, Hinrichs, Benjamin H, Jandarov, Roman, Hildeman, David, Janssen, Edith M, Wise-Draper, Trisha M, Conforti, Laura

“…Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1…”
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Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex by Kuras, Zerrin, Kucher, Vladimir, Gordon, Scott M, Neumeier, Lisa, Chimote, Ameet A, Filipovich, Alexandra H, Conforti, Laura

“…The cAMP/PKA signaling system constitutes an inhibitory pathway in T cells and, although its biochemistry has been thoroughly investigated, its possible…”
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Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells by Lauf, Peter K, Misri, Sandeep, Chimote, Ameet A, Adragna, Norma C

“…This study explores the nature of K fluxes in human lens epithelial cells (LECs) in hyposmotic solutions. Total ion fluxes, Na-K pump, Cl-dependent Na-K-2Cl…”
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Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress by Chimote, Ameet A., Adragna, Norma C., Lauf, Peter K.

“…Membrane transport changes in human lens epithelial (HLE‐B3) cells under hyposmotic and apoptotic stress were compared. Cell potassium content, Ki, uptake of…”
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PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer by Newton, Hannah S, Gawali, Vaibhavkumar S, Chimote, Ameet A, Lehn, Maria A, Palackdharry, Sarah M, Hinrichs, Benjamin H, Jandarov, Roman, Hildeman, David, Janssen, Edith M, Wise-Draper, Trisha M, Conforti, Laura

“…BackgroundImmunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed…”
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