Search Results - "Chimenti, Michael"

T cells, particularly activated CD4+ cells, maintain anti-CD20-mediated NK cell viability and antibody dependent cellular cytotoxicity by Wang, Zhaoming, Chimenti, Michael S., Strouse, Christopher, Weiner, George J.

“…Anti-CD20 monoclonal antibody (mAb) therapy is a mainstay of therapy for B cell malignancies, however many patients fail to respond or eventually develop…”
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Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response by Todd, Brittany P, Chimenti, Michael S, Luo, Zili, Ferguson, Polly J, Bassuk, Alexander G, Newell, Elizabeth A

“…Traumatic brain injury (TBI) is a leading cause of death and disability that lacks neuroprotective therapies. Following a TBI, secondary injury response…”
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Differential gene expression analysis for multi-subject single-cell RNA-sequencing studies with aggregateBioVar by Thurman, Andrew L, Ratcliff, Jason A, Chimenti, Michael S, Pezzulo, Alejandro A

“…Abstract Motivation Single-cell RNA-sequencing (scRNA-seq) provides more granular biological information than bulk RNA-sequencing; bulk RNA sequencing remains…”
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Development of a humanized anti-FABP4 monoclonal antibody for potential treatment of breast cancer by Hao, Jiaqing, Jin, Rong, Yi, Yanmei, Jiang, Xingshan, Yu, Jianyu, Xu, Zhen, Schnicker, Nicholas J, Chimenti, Michael S, Sugg, Sonia L, Li, Bing

“…Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular…”
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The impact of sex and physical activity on the local immune response to muscle pain by Lesnak, Joseph B., Hayashi, Kazuhiro, Plumb, Ashley N., Janowski, Adam J., Chimenti, Michael S., Sluka, Kathleen A.

“…[Display omitted] •Muscle pain caused transcriptional activation of immune pathways in both sexes.•Transcriptional activation of MHC II signaling was…”
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Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis by Hao, Jiaqing, Yu, Jianyu, Yorek, Matthew S., Yu, Chi-Li, Pope, R. Marshall, Chimenti, Michael S., Xiong, Yiqin, Klingelhutz, Aloysius, Jabbari, Ali, Li, Bing

“…One of the hallmarks of intractable psoriasis is neutrophil infiltration in skin lesions. However, detailed molecular mechanisms of neutrophil chemotaxis and…”
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Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes by Gourronc, Francoise A., Chimenti, Michael S., Lehmler, Hans-Joachim, Ankrum, James A., Klingelhutz, Aloysius J.

“…Polychlorinated biphenyls (PCBs) accumulate in adipose tissue and are linked to obesity and diabetes. The congener, PCB52 (2,2′,5,5′-tetrachorobiphenyl), is…”
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pH sensing by FAK-His58 regulates focal adhesion remodeling by Choi, Chang-Hoon, Webb, Bradley A, Chimenti, Michael S, Jacobson, Matthew P, Barber, Diane L

“…Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK),…”
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TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex by Merritt, Nicole, Garcia, Keith, Rajendran, Dushyandi, Lin, Zhen-Yuan, Zhang, Xiaomeng, Mitchell, Katrina M, Borcherding, Nicholas, Fullenkamp, Colleen, Chimenti, Michael S, Gingras, Anne-Claude, Harvey, Kieran F, Tanas, Munir R

“…Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The…”
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Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome by Bullert, Amanda J., Wang, Hui, Linahon, Morgan J., Chimenti, Michael S., Adamcakova-Dodd, Andrea, Li, Xueshu, Dailey, Michael E., Klingelhutz, Aloysius J., Ankrum, James A., Stevens, Hanna E., Thorne, Peter S., Lehmler, Hans-Joachim

“…A semi-volatile polychlorinated biphenyl (PCB) congener, PCB52, is present in the indoor air of schools; however, the effects of inhaled PCB52 on the brain…”
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Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1) by Kumar, Praveen, Chimenti, Michael S., Pemble, Hayley, Schönichen, André, Thompson, Oliver, Jacobson, Matthew P., Wittmann, Torsten

“…A group of diverse proteins reversibly binds to growing microtubule plus ends through interactions with end-binding proteins (EBs). These +TIPs control…”
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Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice by Debreceni, Ivy L, Chimenti, Michael S, Serreze, David V, Geurts, Aron M, Chen, Yi-Guang, Lieberman, Scott M

“…Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice…”
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The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice by Simonsen, Derek, Cady, Nicole, Zhang, Chunyun, Shrode, Rachel L, McCormick, Michael L, Spitz, Douglas R, Chimenti, Michael S, Wang, Kai, Mangalam, Ashutosh, Lehmler, Hans-Joachim

“…Abstract The toxicity of many “inert” ingredients of pesticide formulations, such as safeners, is poorly characterized, despite evidence that humans may be…”
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Transcriptome sequencing of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes by Gourronc, Francoise A., Helm, Brynn K., Robertson, Larry W., Chimenti, Michael S., Joachim-Lehmler, Hans, Ankrum, James A., Klingelhutz, Aloysius J.

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants that accumulate in adipose tissue and have been associated with cardiometabolic disease. We…”
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Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice by Allred, Merri-Grace, Chimenti, Michael S, Ciecko, Ashley E, Chen, Yi-Guang, Lieberman, Scott M

“…Type I interferons (IFNs) are required for spontaneous lacrimal gland inflammation in the nonobese diabetic (NOD) mouse model of Sjögren's disease, but the…”
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Modulation of the Immunological Milieu in Acute Aneurysmal Subarachnoid Hemorrhage: The Potential Role of Monocytes Through CXCL10 Secretion by Sanchez, Sebastian, Chimenti, Michael S, Lu, Yongjun, Sagues, Elena, Gudino, Andres, Dier, Carlos, Hasan, David, Samaniego, Edgar A

“…Emerging evidence indicates that aneurysmal subarachnoid hemorrhage (aSAH) elicits a response from both innate and adaptive immune systems. An upregulation of…”
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Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) by Helm-Kwasny, Brynn Kyleakin, Bullert, Amanda, Wang, Hui, Chimenti, Michael S., Adamcakova-Dodd, Andrea, Jing, Xuefang, Li, Xueshu, Meyerholz, David K., Thorne, Peter S., Lehmler, Hans-Joachim, Ankrum, James A., Klingelhutz, Aloysius J.

“…Elevated airborne PCB levels in older schools are concerning due to their health impacts, including cancer, metabolic dysfunction-associated steatotic liver…”
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Ten simple rules for providing effective bioinformatics research support by Kumuthini, Judit, Chimenti, Michael, Nahnsen, Sven, Peltzer, Alexander, Meraba, Rebone, McFadyen, Ross, Wells, Gordon, Taylor, Deanne, Maienschein-Cline, Mark, Li, Jian-Liang, Thimmapuram, Jyothi, Murthy-Karuturi, Radha, Zass, Lyndon

“…Life scientists are increasingly turning to high-throughput sequencing technologies in their research programs, owing to the enormous potential of these…”
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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression by Kohlmeyer, Jordan L, Lingo, Joshua J, Kaemmer, Courtney A, Scherer, Amanda, Warrier, Akshaya, Voigt, Ellen, Raygoza Garay, Juan A, McGivney, Gavin R, Brockman, Qierra R, Tang, Amy, Calizo, Ana, Pollard, Kai, Zhang, Xiaochun, Hirbe, Angela C, Pratilas, Christine A, Leidinger, Mariah, Breheny, Patrick, Chimenti, Michael S, Sieren, Jessica C, Monga, Varun, Tanas, Munir R, Meyerholz, David K, Darbro, Benjamin W, Dodd, Rebecca D, Quelle, Dawn E

“…Malignant peripheral nerve sheath tumors (MPNST) are lethal, Ras-driven sarcomas that lack effective therapies. We investigated effects of targeting…”
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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway by Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M

“…A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein. Medicinal…”
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