Glioblastomas: correlation between oligodendroglial components, genetic abnormalities, and prognosis

It has been demonstrated that a small percentage (approximately 15%) of glioblastomas (GBM) presents an oligodendroglial component with a variable frequency of chromosome 1p and 19q deletions, the genetic alteration related to chemotherapy response and longer survival in oligodendrogliomas. There is...

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Bibliographic Details
Published in:	Virchows Archiv : an international journal of pathology Vol. 452; no. 5; pp. 481 - 490
Main Authors:	Pinto, Luciana Wernersbach, Mahler Araújo, Maria Betania, Vettore, Andre L., Wernersbach, Liana, Leite, André Campana C., Chimelli, Leila Maria C., Soares, Fernando Augusto
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01-05-2008 Springer Springer Nature B.V
Subjects:	Abnormalities Adolescent Adult Aged Aged, 80 and over Astrocytes - pathology Biological and medical sciences Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - pathology Chemotherapy Child Chromosome 1 Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Correlation Female Fluorescence Fluorescence in situ hybridization Gene Deletion Genetic abnormalities Genotype Glioblastoma - diagnosis Glioblastoma - genetics Glioblastoma - pathology Histology Humans Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Male Medical prognosis Medical sciences Medicine Medicine & Public Health Microsatellite Repeats - genetics Middle Aged Neurology Oligodendroglia - pathology Oligodendroglioma Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Phenotypes Prognosis Retrospective Studies Survival Tumors Tumors of the nervous system. Phacomatoses 1p loss 19q loss Prognostic factors Glioblastoma Oligodendroglial component Nervous system diseases Correlation 19q loss, Prognostic factors Prognosis Chromosome A1 Malignant tumor Chromosome F19 Malignant glioma Anatomic pathology Central nervous system disease Genetics Anomaly Cancer
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Summary:	It has been demonstrated that a small percentage (approximately 15%) of glioblastomas (GBM) presents an oligodendroglial component with a variable frequency of chromosome 1p and 19q deletions, the genetic alteration related to chemotherapy response and longer survival in oligodendrogliomas. There is a growing interest in investigating 1p and 19q losses in hybrid gliomas and their impact on prognosis. A series of 88 GBMs was investigated regarding 1p and/or 19q losses, 24 with oligodendroglioma-like areas, using quantitative microsatellite analysis and/or fluorescent in situ hybridization. When present, the oligodendroglial and astrocytic components were independently investigated. Clinical data, histology, and 1p/19q status were correlated. Tumors with oligodendroglial components showed three cases each of 1p or 19q loss and one with combined 1p/19q loss. No difference in 1p or 19q status was observed between the oligodendroglial and astrocytic components. Conventional GBM demonstrated isolated 1p loss in four cases and 19q loss in five. No association was seen between 1p/19q status and histology. Deletions at 1p and/or 19q were infrequent in GBMs with oligodendroglial components. Despite the hybrid phenotype, the pattern of genetic changes at 1p and 19q was not different from that usually observed in conventional GBMs, nor did it show any correlation with survival.
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-007-0562-9