Search Results - "Chilvers, Edwin R."

Priming and de‐priming of neutrophil responses in vitro and in vivo by Vogt, Katja L., Summers, Charlotte, Chilvers, Edwin R., Condliffe, Alison M.

“…The activation status of neutrophils can cycle from basal through primed to fully activated (“green‐amber‐red”), and at least in vitro, primed cells can…”
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Viscoelastic properties of differentiating blood cells are fate- and function-dependent by Ekpenyong, Andrew E, Whyte, Graeme, Chalut, Kevin, Pagliara, Stefano, Lautenschläger, Franziska, Fiddler, Christine, Paschke, Stephan, Keyser, Ulrich F, Chilvers, Edwin R, Guck, Jochen

“…Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is…”
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Mechanics meets medicine by Guck, Jochen, Chilvers, Edwin R

“…A new high-throughput measurement technique moves mechanical phenotyping of cells in malignant pleural effusions closer to the clinic (Tse et al., this issue)…”
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Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition by Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R

“…Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin…”
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Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice by Li, Wei, Long, Lu, Yang, Xudong, Tong, Zhen, Southwood, Mark, King, Ross, Caruso, Paola, Upton, Paul D, Yang, Peiran, Bocobo, Geoffrey A, Nikolic, Ivana, Higuera, Angelica, Salmon, Richard M, Jiang, He, Lodge, Katharine M, Hoenderdos, Kim, Baron, Rebecca M, Yu, Paul B, Condliffe, Alison M, Summers, Charlotte, Nourshargh, Sussan, Chilvers, Edwin R, Morrell, Nicholas W

“…Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating…”
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C13orf31 (FAMIN) is a central regulator of immunometabolic function by Cader, M Zaeem, Boroviak, Katharina, Zhang, Qifeng, Assadi, Ghazaleh, Kempster, Sarah L, Sewell, Gavin W, Saveljeva, Svetlana, Ashcroft, Jonathan W, Clare, Simon, Mukhopadhyay, Subhankar, Brown, Karen P, Tschurtschenthaler, Markus, Raine, Tim, Doe, Brendan, Chilvers, Edwin R, Griffin, Jules L, Kaneider, Nicole C, Floto, R Andres, D'Amato, Mauro, Bradley, Allan, Wakelam, Michael J O, Dougan, Gordon, Kaser, Arthur

“…Variants of the human gene C13orf31 ( LACC1 ) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called…”
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C5a anaphylatoxin and its role in critical illness‐induced organ dysfunction by Wood, Alexander J. T., Vassallo, Arlette, Summers, Charlotte, Chilvers, Edwin R., Conway‐Morris, Andrew

“…Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in…”
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Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo by Poole, Emma, Juss, Jatinder K., Krishna, Benjamin, Herre, Jurgen, Chilvers, Edwin R., Sinclair, John

“…Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in…”
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Metabolic Profiling of Human Eosinophils by Porter, Linsey, Toepfner, Nicole, Bashant, Kathleen R, Guck, Jochen, Ashcroft, Margaret, Farahi, Neda, Chilvers, Edwin R

“…Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, which are known to rely…”
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Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model by Lau, Doreen, Garçon, Fabien, Chandra, Anita, Lechermann, Laura M, Aloj, Luigi, Chilvers, Edwin R, Corrie, Pippa G, Okkenhaug, Klaus, Gallagher, Ferdia A

“…Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful adoptive T-cell therapy. Intravital microscopy is a powerful…”
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Quantification of Lung PET Images: Challenges and Opportunities by Chen, Delphine L, Cheriyan, Joseph, Chilvers, Edwin R, Choudhury, Gourab, Coello, Christopher, Connell, Martin, Fisk, Marie, Groves, Ashley M, Gunn, Roger N, Holman, Beverley F, Hutton, Brian F, Lee, Sarah, MacNee, William, Mohan, Divya, Parr, David, Subramanian, Deepak, Tal-Singer, Ruth, Thielemans, Kris, van Beek, Edwin J R, Vass, Laurence, Wellen, Jeremy W, Wilkinson, Ian, Wilson, Frederick J

“…Millions of people are affected by respiratory diseases, leading to a significant health burden globally. Because of the current insufficient knowledge of the…”
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Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma by Farahi, Neda, Paige, Ellie, Balla, Jozef, Prudence, Emily, Ferreira, Ricardo C, Southwood, Mark, Appleby, Sarah L, Bakke, Per, Gulsvik, Amund, Litonjua, Augusto A, Sparrow, David, Silverman, Edwin K, Cho, Michael H, Danesh, John, Paul, Dirk S, Freitag, Daniel F, Chilvers, Edwin R

“…The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other…”
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In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K.A., Berair, Rachid, Lok, Laurence S.C., Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P., Summers, Charlotte, Wong, Anna, Solanki, Chandra K., Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A. Michael, Brightling, Christopher E., Condliffe, Alison M., Chilvers, Edwin R.

“…[...]there is a need to develop noninvasive biomarkers of tissue eosinophilia. [...]although we have previously published a rigorous assessment of the…”
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Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands by Herre, Jurgen, Grönlund, Hans, Brooks, Heather, Hopkins, Lee, Waggoner, Lisa, Murton, Ben, Gangloff, Monique, Opaleye, Olaniyi, Chilvers, Edwin R, Fitzgerald, Kate, Gay, Nick, Monie, Tom, Bryant, Clare

“…Allergic responses can be triggered by structurally diverse allergens. Most allergens are proteins, yet extensive research has not revealed how they initiate…”
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The mechanics of myeloid cells by Bashant, Kathleen R, Toepfner, Nicole, Day, Christopher J, Mehta, Nehal N, Kaplan, Mariana J, Summers, Charlotte, Guck, Jochen, Chilvers, Edwin R

“…The effects of cell size, shape and deformability on cellular function have long been a topic of interest. Recently, mechanical phenotyping technologies…”
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The Neutrophil Life Cycle by Hidalgo, Andrés, Chilvers, Edwin R., Summers, Charlotte, Koenderman, Leo

“…Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells…”
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Future treatment in patients with chronic obstructive pulmonary disease: To reverse or not to reverse steroid resistance—that is the question by Koenderman, Leo, PhD, Chilvers, Edwin R., PhD

“…In susceptible subjects airways inflammation becomes autonomous in part through pathogen-associated molecular patterns and tissue-derived damage-associated…”
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Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils by McGovern, Naomi N, Cowburn, Andrew S, Porter, Linsey, Walmsley, Sarah R, Summers, Charlotte, Thompson, Alfred A R, Anwar, Sadia, Willcocks, Lisa C, Whyte, Moira K B, Condliffe, Alison M, Chilvers, Edwin R

“…Neutrophils play a central role in the innate immune response and a critical role in bacterial killing. Most studies of neutrophil function have been conducted…”
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Cardiovascular adaptation to hypoxia and the role of peripheral resistance by Cowburn, Andrew S, Macias, David, Summers, Charlotte, Chilvers, Edwin R, Johnson, Randall S

“…Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds…”
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Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects by Farahi, Neda, Singh, Nanak R., Heard, Sarah, Loutsios, Chrystalla, Summers, Charlotte, Solanki, Chandra K., Solanki, Kishor, Balan, Kottekkattu K., Ruparelia, Prina, Peters, A. Michael, Condliffe, Alison M., Chilvers, Edwin R.

“…Eosinophils are the major cellular effectors of allergic inflammation and represent an important therapeutic target. Although the genesis and activation of…”
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