Search Results - "Chillappagari, Shashipavan"

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism by Chillappagari, Shashipavan, Belapurkar, Ratnal, Möller, Andreas, Molenda, Nicole, Kracht, Michael, Rohrbach, Susanne, Schmitz, M. Lienhard

“…The intracellular levels of the cytoprotective enzyme heme oxygenase-1 (HO-1) are tightly controlled. Here, we reveal a novel mechanism preventing the…”
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Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis by Korfei, Martina, Stelmaszek, Daniel, MacKenzie, BreAnne, Skwarna, Sylwia, Chillappagari, Shashipavan, Bach, Anna C, Ruppert, Clemens, Saito, Shigeki, Mahavadi, Poornima, Klepetko, Walter, Fink, Ludger, Seeger, Werner, Lasky, Joseph A, Pullamsetti, Soni S, Krämer, Oliver H, Guenther, Andreas

“…Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a poor prognosis. Pirfenidone is the first antifibrotic agent to be approved for…”
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SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression by Schmitz, M. Lienhard, Dreute, Jan, Pfisterer, Maximilian, Günther, Stefan, Kracht, Michael, Chillappagari, Shashipavan

“…The functionally redundant ubiquitin E3 ligases SIAH1 and SIAH2 have been implicated in the regulation of metabolism and the hypoxic response, while their role…”
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Therapeutic induction of Bcl2‐associated athanogene 3‐mediated autophagy in idiopathic pulmonary fibrosis by Chillappagari, Shashipavan, Schwarz, Julian, Kesireddy, Vidyasagar, Knoell, Jessica, Korfei, Martina, Hoetzenecker, Konrad, Schmitz, M. Lienhard, Behl, Christian, Bellusci, Saverio, Guenther, Andreas, Mahavadi, Poornima

“…Background Exaggerated fibroblast proliferation is a well‐known feature in idiopathic pulmonary fibrosis (IPF) which may be – in part – due to insufficient…”
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BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis by Chillappagari, Shashipavan, Guenther, Andreas, Mahavadi, Poornima

“…Idiopathic pulmonary fibrosis (IPF) is a dreadful and fatal disease of unknown etiology, for which no cure exists. Autophagy, a lysosomal cellular surveillance…”
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Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells by Chillappagari, Shashipavan, Garapati, Virajith, Mahavadi, Poornima, Naehrlich, Lutz, Schmeck, Bernd T., Schmitz, M. Lienhard, Guenther, Andreas

“…•Defective inhibitory activity of miR-155 on BACH1 in CF.•Increased BACH1 protein stability in CF.•Various defective regulatory loops account for dysregulated…”
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