Search Results - "Chillón, M Carmen"
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NEDD9 , an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients
Published in Oncotarget (29-09-2017)“…Intermediate-risk acute myeloid leukemia (IR-AML) is the largest subgroup of AML patients and is highly heterogeneous. Whereas adverse and favourable risk…”
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Liquid biopsy: a non‐invasive approach for Hodgkin lymphoma genotyping
Published in British journal of haematology (01-11-2021)“…Summary The Hodgkin lymphoma (HL) genomic landscape is hardly known due to the scarcity of tumour cells in the tissue. Liquid biopsy employing circulating…”
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Liquid biopsy for molecular characterization of diffuse large B-cell lymphoma and early assessment of minimal residual disease
Published in British journal of haematology (01-07-2024)“…Circulating tumour DNA (ctDNA) allows genotyping and minimal residual disease (MRD) detection in lymphomas. Using a next-generation sequencing (NGS) approach…”
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Molecular Characterization of Immunoglobulin Gene Rearrangements in Diffuse Large B-Cell Lymphoma: Antigen-Driven Origin and IGHV4-34 as a Particular Subgroup of the Non-GCB Subtype
Published in The American journal of pathology (01-11-2012)“…The pathogenesis of diffuse large B-cell lymphoma (DLBCL) remains partially unknown. The analysis of the B-cell receptor of the malignant cells could…”
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A New Next-Generation Sequencing Strategy for the Simultaneous Analysis of Mutations and Chromosomal Rearrangements at DNA Level in Acute Myeloid Leukemia Patients
Published in The Journal of molecular diagnostics : JMD (01-01-2020)“…Acute myeloid leukemias (AMLs) are currently genomically characterized by karyotype, fluorescence in situ hybridization (FISH), real-time quantitative PCR, and…”
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HLA specificities are associated with prognosis in IGHV-mutated CLL-like high-count monoclonal B cell lymphocytosis
Published in PloS one (01-03-2017)“…Molecular alterations leading progression of asymptomatic CLL-like high-count monoclonal B lymphocytosis (hiMBL) to chronic lymphocytic leukemia (CLL) remain…”
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HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma
Published in Blood (22-08-2013)“…Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease influenced by genetic and environmental factors. The role of the HLA system in tumor antigen…”
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Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
Published in Cancers (13-11-2018)“…In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to…”
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Immunoglobulin gene rearrangement IGHV3-48 is a predictive marker of histological transformation into aggressive lymphoma in follicular lymphomas
Published in Blood cancer journal (New York) (17-06-2019)“…Follicular lymphoma (FL) is a heterogeneous disease whose pathogenesis remains partially unknown. Around 20% of FL patients experience early progression or…”
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Genetic complexity impacts the clinical outcome of follicular lymphoma patients
Published in Blood cancer journal (New York) (11-01-2021)Get full text
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Do endothelial cells belong to the primitive stem leukemic clone in CML? Role of extracellular vesicles
Published in Leukemia research (01-08-2015)“…Abstract The expression of BCR-ABL in hematopoietic stem cells is a well-defined primary event in chronic myeloid leukemia (CML). Some reports have described…”
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Preferential Acquision of N-Glycosylation Sites in the VDJ Region in Germinal Center B-Cell-Like Difusse Large B-Cell Lymphoma
Published in Blood (16-11-2012)“…Abstract 1589 Acquired potentially N-glycosylation sites are produced by somatic hypermutation (SHM) in the immunoglobulin (Ig) variable region. This…”
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Relationship Between HLA Class I and II Polymorphisms with Susceptibility and Clinical Outcome in Diffuse Large B-Cell Lymphoma
Published in Blood (16-11-2012)“…Abstract 2680 The Human Leukocyte Antigen (HLA) system plays an important role in antitumor immune response. In the last years, different genome-wide…”
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Molecular Characterization of Immunoglobulin Gene Rearrangements in Diffuse Large B-Cell Lymphoma
Published in The American journal of pathology (01-11-2012)“…The pathogenesis of diffuse large B-cell lymphoma (DLBCL) remains partially unknown. The analysis of the B-cell receptor of the malignant cells could…”
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Clinical and Prognostic Value of Discrepancies in Microsatellite DNA Regions Between Recipient and Donor in Human Leukocyte Antigen-Identical Allogeneic Transplantation Setting
Published in Transplantation (15-10-2008)“…Detection of recipient versus donor disparities in microsatellite DNA regions (short tandem repeats [STR]) allows for sensitive and specific monitorization of…”
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Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma
Published in Haematologica (Roma) (01-07-2005)“…Hematology Service, University Hospital of Salamanca and Center for Cancer Research, University of Salamanca, Spain. BACKGROUND AND OBJECTIVES: Analysis of IgH…”
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Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients
Published in Blood cancer journal (New York) (06-02-2020)“…Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma…”
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FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor
Published in The hematology journal : the official journal of the European Haematology Association (2004)“…FLT3: gene alterations (internal tandem duplications - ITDs - and D835 mutations) are thought to be associated with poor-risk acute myeloid leukemia (AML)…”
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A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma
Published in The Journal of molecular diagnostics : JMD (01-01-2017)“…Identification and characterization of genetic alterations are essential for diagnosis of multiple myeloma and may guide therapeutic decisions. Currently,…”
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