Search Results - "Chilenski, Jennifer R."

Highly Enantioselective Hydrogenation of Aromatic-Heteroaromatic Ketones by Chen, Cheng-yi, Reamer, Robert A, Chilenski, Jennifer R, McWilliams, Chris J

“…Asymmetric hydrogenation of ketone 1 using trans-RuCl2[(R)-xylbinap][(R)-daipen] (3) as a catalyst afforded secondary alcohol 2 quantitatively and in 99.4% ee…”
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An Efficient Asymmetric Synthesis of an Estrogen Receptor Modulator by Sulfoxide-Directed Borane Reduction by Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard, Trost, Barry M.

“…An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic…”
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Nucleophilic Displacement at Benzhydryl Centers:  Asymmetric Synthesis of 1,1-Diarylalkyl Derivatives by Bolshan, Yuri, Chen, Cheng-yi, Chilenski, Jennifer R, Gosselin, Francis, Mathre, David J, O'Shea, Paul D, Roy, Amélie, Tillyer, Richard D

“…Activation of substituted 1,1-diarylmethanols as their corresponding toluenesulfonates and subsequent displacement with a range of carbon, nitrogen, oxygen,…”
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Scalable, efficient process for the synthesis of ( R)-3,5-bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex by Hansen, Karl B., Chilenski, Jennifer R., Desmond, Richard, Devine, Paul N., Grabowski, Edward J.J., Heid, Richard, Kubryk, Michele, Mathre, David J., Varsolona, Richard

“…( R)-3,5-Bistrifluoromethylphenyl ethanol 2, a key building block in the synthesis of aprepitant, has been synthesized from ketone 5 via catalytic asymmetric…”
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Unique Tandem Heck-Lactamization Naphthyridinone Ring Formation between Acrylanilides and Halogenated Pyridines by Cvetovich, Raymond J, Reamer, Robert A, DiMichele, Lisa, Chung, John Y. L, Chilenski, Jennifer R

“…The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-Heck products or undergo an unusual tandem…”
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Microplate evaluation of process adsorbents by Welch, Christopher J., Shaimi, Mohamed, Biba, Mirlinda, Chilenski, Jennifer R., Szumigala Jr, Ronald H., Dolling, Ulf, Mathre, David J., Reider, Paul J.

“…A microplate‐based assay to rapidly identify adsorbents suitable for removing process impurities is described. A solution containing both product and impurity…”
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Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate−ZnCl2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor by Chung, John Y. L, Cvetovich, Raymond J, Tsay, Fuh-Rong, Dormer, Peter G, DiMichele, Lisa, Mathre, David J, Chilenski, Jennifer R, Mao, Bing, Wenslow, Robert

“…A six-step preparation of thrombin inhibitor drug candidate 1 from pyrazinone 7 in 47% overall yield is described. The problem of low reactivity between weak…”
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The conformational bias of aryl, arylsulfonyl geminally substituted tertiary carbon centers: applications in substrate-based stereocontrol by Scott, Jeremy P, Mullens, Peter R, Brewer, Sarah E, Brands, Karel M J, Chilenski, Jennifer R, Davies, Antony J, Gibb, Andrew D, Lieberman, David R, Oliver, Steven F, Dolling, Ulf-H

“…Intramolecular nitrile oxide-olefin cycloaddition to form hexahydrobenzisoxazole 14, which engenders a phenylsulfonyl, 2,5-difluorophenyl geminally substituted…”
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Highly Enantioselective Hydrogenation of Aromatic−Heteroaromatic Ketones by Chen, Cheng-yi, Reamer, Robert A, Chilenski, Jennifer R, McWilliams, J. Christopher

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α-Methoxyphenyl acetic acid (MPA) for the configurational assignment of aromatic–heteroaromatic carbinols by 1H NMR spectroscopy by Chen, Cheng-yi, Reamer, Robert A., Roy, Amélie, Chilenski, Jennifer R.

“…[Display omitted] Configurational assignment for a wide array of aromatic–heteroaromatic carbinols using NMR method employing α-methoxyphenyl acetic acid (MPA)…”
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Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate−ZnCl 2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor by Chung, John Y. L., Cvetovich, Raymond J., Tsay, Fuh-Rong, Dormer, Peter G., DiMichele, Lisa, Mathre, David J., Chilenski, Jennifer R., Mao, Bing, Wenslow, Robert

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