Search Results - "Childs, Gwen V."

The Importance of Leptin to Reproduction by Childs, Gwen V, Odle, Angela K, MacNicol, Melanie C, MacNicol, Angus M

“…A healthy nutritional state is required for all aspects of reproduction and is signaled by the adipokine leptin. Leptin acts in a relatively narrow…”
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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy by Zhao, Shangang, Zhu, Yi, Schultz, Robbie D, Li, Na, He, Zhenyan, Zhang, Zhuzhen, Caron, Alexandre, Zhu, Qingzhang, Sun, Kai, Xiong, Wei, Deng, Hui, Sun, Jia, Deng, Yingfeng, Kim, Min, Lee, Charlotte E, Gordillo, Ruth, Liu, Tiemin, Odle, Angela K, Childs, Gwen V, Zhang, Ningyan, Kusminski, Christine M, Elmquist, Joel K, Williams, Kevin W, An, Zhiqiang, Scherer, Philipp E

“…The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the…”
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Molecular Mechanisms of Pituitary Cell Plasticity by Childs, Gwen V, MacNicol, Angus M, MacNicol, Melanie C

“…The mechanisms that mediate plasticity in pituitary function have long been a subject of vigorous investigation. Early studies overcame technical barriers and…”
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Post-Transcriptional Regulation of Gnrhr : A Checkpoint for Metabolic Control of Female Reproduction by Odle, Angela K, MacNicol, Melanie C, Childs, Gwen V, MacNicol, Angus M

“…The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity…”
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs by Banik, Jewel, Moreira, Ana Rita Silva, Lim, Juchan, Tomlinson, Sophia, Hardy, Linda L., Lagasse, Alex, Haney, Anessa, Crimmins, Meghan R., Boehm, Ulrich, Odle, Angela K., MacNicol, Melanie C., Childs, Gwen V., MacNicol, Angus M.

“…The pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including…”
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Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence by Odle, Angela K, Akhter, Noor, Syed, Mohsin M, Allensworth-James, Melody L, Beneš, Helen, Melgar Castillo, Andrea I, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…The adipokine leptin signals the body's nutritional status to the brain, and particularly, the hypothalamus. However, leptin receptors (LEPRs) can be found all…”
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Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility by Akhter, Noor, CarlLee, Tyler, Syed, Mohsin M, Odle, Angela K, Cozart, Michael A, Haney, Anessa C, Allensworth-James, Melody L, Beneš, Helen, Childs, Gwen V

“…The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient…”
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Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2 by MacNicol, Melanie C., Cragle, Chad E., McDaniel, F. Kennedy, Hardy, Linda L., Wang, Yan, Arumugam, Karthik, Rahmatallah, Yasir, Glazko, Galina V., Wilczynska, Ania, Childs, Gwen V., Zhou, Daohong, MacNicol, Angus M.

“…The Musashi family of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predominantly through translational repression…”
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Commentary on “Classifications of Anterior Pituitary Cell Types With Immunoenzyme Histochemistry”: Dr. Paul Nakane Blazed the Trail to Modern Technology by Childs, Gwen V.

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Gametes in Paradise–How the Oviduct Epithelial Microenvironment Supports and Protects Against Maternal Stress by Childs, Gwen V

“…Key Words: oviduct, estradiol, progesterone, cortisol, stress, air-liquid interface Abbreviations: E2, 17[beta]-estradiol; ER[alpha], estrogen receptor a; P4,…”
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410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet by Miles, Tiffany K., Allensworth, Melody L., Silva Moreira, Ana Rita, Odle, Angela K., Haney, Anessa, Lagasse, Alexandra, MacNicol, Angus M., Childs, Gwen V.

“…OBJECTIVES/GOALS: Maternal undernutrition, a form of malnutrition, can alter neonatal leptin signaling and result in metabolic dysfunction in adulthood. We…”
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SMAD-FOXL2 Regulation of FSHB: A Game of Human and Mouse by Odle, Angela K, Childs, Gwen V

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Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin by Odle, Angela K, Haney, Anessa, Allensworth-James, Melody, Akhter, Noor, Childs, Gwen V

“…Leptin is a cytokine produced by white fat cells, skeletal muscle, the placenta, and the pituitary gland among other tissues. Best known for its role in…”
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ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release by MacNicol, Angus M, Odle, Angela K, Childs, Gwen V

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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism by Miles, Tiffany K, Odle, Angela K, Byrum, Stephanie D, Lagasse, Alex, Haney, Anessa, Ortega, Victoria G, Bolen, Cole R, Banik, Jewel, Reddick, Milla M, Herdman, Ashley, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Abstract Anterior pituitary cell function requires a high level of protein synthesis and secretion which depend heavily on mitochondrial adenosine triphosphate…”
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The War on the Placenta: The Differing Battles of High-Fat Diet and Obesity by Odle, Angela, Allensworth-James, Melody, Childs, Gwen V

“…Commentary on Mahany et al., “Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.”…”
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Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation by Cragle, Chad E., MacNicol, Melanie C., Byrum, Stephanie D., Hardy, Linda L., Mackintosh, Samuel G., Richardson, William A., Gray, Nicola K., Childs, Gwen V., Tackett, Alan J., MacNicol, Angus M.

“…The Musashi family of mRNA translational regulators controls both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs…”
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Alzheimer amyloid-β- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood by Hendrix, Rachel D., Ou, Yang, Davis, Jakeira E., Odle, Angela K., Groves, Thomas R., Allen, Antiño R., Childs, Gwen V., Barger, Steven W.

“…Alzheimer's disease (AD) is associated with disturbances in blood glucose regulation, and type-2 diabetes elevates the risk for dementia. A role for amyloid-β…”
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Single nucleus multi-omics regulatory landscape of the murine pituitary by Ruf-Zamojski, Frederique, Zhang, Zidong, Zamojski, Michel, Smith, Gregory R., Mendelev, Natalia, Liu, Hanqing, Nudelman, German, Moriwaki, Mika, Pincas, Hanna, Castanon, Rosa Gomez, Nair, Venugopalan D., Seenarine, Nitish, Amper, Mary Anne S., Zhou, Xiang, Ongaro, Luisina, Toufaily, Chirine, Schang, Gauthier, Nery, Joseph R., Bartlett, Anna, Aldridge, Andrew, Jain, Nimisha, Childs, Gwen V., Troyanskaya, Olga G., Ecker, Joseph R., Turgeon, Judith L., Welt, Corrine K., Bernard, Daniel J., Sealfon, Stuart C.

“…To provide a multi-omics resource and investigate transcriptional regulatory mechanisms, we profile the transcriptome, chromatin accessibility, and methylation…”
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Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle by Moreira, Ana Rita Silva, Lim, Juchan, Urbaniak, Alicja, Banik, Jewel, Bronson, Katherine, Lagasse, Alex, Hardy, Linda, Haney, Anessa, Allensworth, Melody, Miles, Tiffany K, Gies, Allen, Byrum, Stephanie D, Wilczynska, Ania, Boehm, Ulrich, Kharas, Michael, Lengner, Christopher, MacNicol, Melanie C, Childs, Gwen V, MacNicol, Angus M, Odle, Angela K

“…Abstract The anterior pituitary controls key biological processes, including growth, metabolism, reproduction, and stress responses through distinct cell types…”
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