Search Results - "Childress, Paul"

Gene‐Metabolite Network Linked to Inhibited Bioenergetics in Association With Spaceflight‐Induced Loss of Male Mouse Quadriceps Muscle by Chakraborty, Nabarun, Waning, David L, Gautam, Aarti, Hoke, Allison, Sowe, Bintu, Youssef, Dana, Butler, Stephan, Savaglio, Michael, Childress, Paul J, Kumar, Raina, Moyler, Candace, Dimitrov, George, Kacena, Melissa A, Hammamieh, Rasha

“…ABSTRACT Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading…”
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A translational regulatory mechanism mediated by hypusinated eukaryotic initiation factor 5A facilitates beta cell identity and function by Connors, Craig T, Villaca, Catharina B P, Anderson-Baucum, Emily K, Rosario, Spencer R, Rutan, Caleb D, Childress, Paul J, Padgett, Leah R, Robertson, Morgan A, Mastracci, Teresa L

“…As professional secretory cells, beta cells require adaptable mRNA translation to facilitate a rapid synthesis of proteins, including insulin, in response to…”
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Systemic effects of BMP2 treatment of fractures on non-injured skeletal sites during spaceflight by Zamarioli, Ariane, Adam, Gremah, Maupin, Kevin A., Childress, Paul J., Brinker, Alexander, Ximenez, Joao P. B., Chakraborty, Nabarun, Gautam, Aarti, Hammamieh, Rasha, Kacena, Melissa A.

“…Unloading associated with spaceflight results in bone loss and increased fracture risk. Bone morphogenetic protein 2 (BMP2) is known to enhance bone formation,…”
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Neonatal Osteomacs and Bone Marrow Macrophages Differ in Phenotypic Marker Expression and Function by Mohamad, Safa F, Gunawan, Andrea, Blosser, Rachel, Childress, Paul, Aguilar‐Perez, Alexandra, Ghosh, Joydeep, Hong, Jung Min, Liu, Jianyun, Kanagasabapathy, Deepa, Kacena, Melissa A, Srour, Edward F, Bruzzaniti, Angela

“…ABSTRACT Osteomacs (OM) are specialized bone‐resident macrophages that are a component of the hematopoietic niche and support bone formation. Also located in…”
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The effects of spaceflight and fracture healing on distant skeletal sites by Dadwal, Ushashi C., Maupin, Kevin A., Zamarioli, Ariane, Tucker, Aamir, Harris, Jonathan S., Fischer, James P., Rytlewski, Jeffery D., Scofield, David C., Wininger, Austin E., Bhatti, Fazal Ur Rehman, Alvarez, Marta, Childress, Paul J., Chakraborty, Nabarun, Gautam, Aarti, Hammamieh, Rasha, Kacena, Melissa A.

“…Spaceflight results in reduced mechanical loading of the skeleton, which leads to dramatic bone loss. Low bone mass is associated with increased fracture risk,…”
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Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality by Shao, Yu, Wichern, Emily, Childress, Paul J, Adaway, Michele, Misra, Jagannath, Klunk, Angela, Burr, David B, Wek, Ronald C, Mosley, Amber L, Liu, Yunlong, Robling, Alexander G, Brustovetsky, Nickolay, Hamilton, James, Jacobs, Kylie, Vashishth, Deepak, Stayrook, Keith R, Allen, Matthew R, Wallace, Joseph M, Bidwell, Joseph P

“…A goal of osteoporosis therapy is to restore lost bone with structurally sound tissue. Mice lacking the transcription factor nuclear matrix protein 4 ( , , , )…”
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The effects of high fat diet, bone healing, and BMP-2 treatment on endothelial cell growth and function by Bhatti, Fazal Ur Rehman, Dadwal, Ushashi C., Valuch, Conner R., Tewari, Nikhil P., Awosanya, Olatundun D., de Andrade Staut, Caio, Sun, Seungyup, Mendenhall, Stephen K., Perugini, Anthony J., Nagaraj, Rohit U., Battina, Hanisha L., Nazzal, Murad K., Blosser, Rachel J., Maupin, Kevin A., Childress, Paul J., Li, Jiliang, Kacena, Melissa A.

“…Angiogenesis is a vital process during the regeneration of bone tissue. The aim of this study was to investigate angiogenesis at the fracture site as well as…”
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Anabolic and Catabolic Regimens of Human Parathyroid Hormone 1–34 Elicit Bone- and Envelope-Specific Attenuation of Skeletal Effects in Sost-Deficient Mice by Robling, Alexander G, Kedlaya, Rajendra, Ellis, Shana N, Childress, Paul J, Bidwell, Joseph P, Bellido, Teresita, Turner, Charles H

“…PTH is a potent calcium-regulating factor that has skeletal anabolic effects when administered intermittently or catabolic effects when maintained at…”
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Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight by Chakraborty, Nabarun, Zamarioli, Ariane, Gautam, Aarti, Campbell, Ross, Mendenhall, Stephen K, Childress, Paul J., Dimitrov, George, Sowe, Bintu, Tucker, Aamir, Zhao, Liming, Hammamieh, Rasha, Kacena, Melissa A.

“…Adverse effects of spaceflight on musculoskeletal health increase the risk of bone injury and impairment of fracture healing. Its yet elusive molecular…”
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Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function by Mohamad, Safa F., Xu, Linlin, Ghosh, Joydeep, Childress, Paul J., Abeysekera, Irushi, Himes, Evan R., Wu, Hao, Alvarez, Marta B., Davis, Korbin M., Aguilar-Perez, Alexandra, Hong, Jung Min, Bruzzaniti, Angela, Kacena, Melissa A., Srour, Edward F.

“…Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell…”
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Functional Impairment of Bone Formation in the Pathogenesis of Osteoporosis: The Bone Marrow Regenerative Competence by Bidwell, Joseph P., Alvarez, Marta B., Hood, Mark, Childress, Paul

“…The skeleton is a high-renewal organ that undergoes ongoing cycles of remodeling. The regenerative bone formation arm ultimately declines in the aging,…”
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Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation by Emmakah, Arbi M, Arman, Hussain E, Alvarez, Marta B, Childress, Paul J, Bidwell, Joseph P, Goebel, William S, Gabriel Chu, Tien-Min, Kacena, Melissa A

“…Megakaryocytes (MKs) can induce proliferation of calvarial osteoblasts [Ciovacco et al., 2009], but this same phenomenon has not been reported for bone marrow…”
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Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites by Zamarioli, Ariane, Campbell, Zachery R., Maupin, Kevin A., Childress, Paul J., Ximenez, Joao P. B., Adam, Gremah, Chakraborty, Nabarun, Gautam, Aarti, Hammamieh, Rasha, Kacena, Melissa A.

“…With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we…”
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Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station by Maupin, Kevin A., Childress, Paul, Brinker, Alexander, Khan, Faisal, Abeysekera, Irushi, Aguilar, Izath Nizeet, Olivos, David J., Adam, Gremah, Savaglio, Michael K., Ganesh, Venkateswaran, Gorden, Riley, Mannfeld, Rachel, Beckner, Elliott, Horan, Daniel J., Robling, Alexander G., Chakraborty, Nabarun, Gautam, Aarti, Hammamieh, Rasha, Kacena, Melissa A.

“…Gravity has an important role in both the development and maintenance of bone mass. This is most evident in the rapid and intense bone loss observed in both…”
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Cohousing Male Mice with and without Segmental Bone Defects by Rytlewski, Jeffrey D, Childress, Paul J, Scofield, David C, Khan, Faisal, Alvarez, Marta B, Tucker, Aamir T, Harris, Jonathan S, Peveler, Jessica L, Hickman, Debra L, Chu, Tien-Min G, Kacena, Melissa A

“…Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries…”
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Nmp4/CIZ: Road block at the intersection of PTH and load by Childress, Paul, Robling, Alexander G, Bidwell, Joseph P

“…Abstract Teriparatide (parathyroid hormone, [PTH]) is the only FDA-approved drug that replaces bone lost to osteoporosis. Enhancing PTH efficacy will improve…”
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RAGE supports parathyroid hormone-induced gains in femoral trabecular bone by Philip, Binu K, Childress, Paul J, Robling, Alexander G, Heller, Aaron, Nawroth, Peter P, Bierhaus, Angelika, Bidwell, Joseph P

“…Parathyroid hormone (PTH) restores bone mass to the osteopenic skeleton, but significant questions remain as to the underlying mechanisms. The receptor for…”
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Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency by He, Yongzheng, Childress, Paul, Hood, Jr, Mark, Alvarez, Marta, Kacena, Melissa A, Hanlon, Michael, McKee, Bryce, Bidwell, Joseph P, Yang, Feng-Chun

“…Parathyroid hormone (PTH) anabolic osteoporosis therapy is intrinsically limited by unknown mechanisms. We previously showed that disabling the transcription…”
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Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone by Robling, Alexander G., Childress, Paul, Yu, Jun, Cotte, Jessica, Heller, Aaron, Philip, Binu K., Bidwell, Joseph P.

“…The nucleocytoplasmic shuttling transcription factor Nmp4/CIZ (nuclear matrix protein 4/cas interacting zinc finger protein) is a ubiquitously expressed…”
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Uphill running does not exacerbate collagenase-induced pathological changes in the Achilles tendon of rats selectively bred for high-capacity running by Dirks, Rachel C, Galley, Matthew R, Childress, Paul J, Fearon, Angela M, Scott, Alexander, Koch, Lauren G, Britton, Steven L, Warden, Stuart J

“…The Achilles tendon is a frequent site for degeneration, and advanced understanding of this pathology requires an animal model that replicates the human…”
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