Search Results - "Childers, Kaleen K."

A one-step, multi-component reaction for the synthesis of fully substituted 5-amino-4-carboxamidthiazoles by Childers, Kaleen K., Haidle, Andrew M., Machacek, Michelle R., Rogers, J. Patrick, Romeo, Eric

“…[Display omitted] A novel multi-component reaction has been developed for the synthesis of fully substituted 5-amino-4-carboxamidthiazoles. Condensation of an…”
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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors by Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael

“…The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for…”
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Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors by Katz, Jason D., Haidle, Andrew, Childers, Kaleen K., Zabierek, Anna A., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Su, Hua-Poo, Munshi, Sanjeev, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

“…[Display omitted] The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal…”
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MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation by Haidle, Andrew M., Childers, Kaleen K., Zabierek, Anna A., Katz, Jason D., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

“…[Display omitted] Attempts to optimize pharmacokinetic properties in a promising series of pyrrolopyrimidinone MARK inhibitors for the treatment of Alzheimer’s…”
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Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms by Haidle, Andrew M, Zabierek, Anna A, Childers, Kaleen K, Rosenstein, Craig, Mathur, Anjili, Altman, Michael D, Chan, Grace, Xu, Lin, Bachman, Eric, Mo, Jan-Rung, Bouthillette, Melaney, Rush, Thomas, Tempest, Paul, Marshall, C Gary, Young, Jonathan R

“…A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric…”
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