Search Results - "Child, Stephanie J"

Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses by Elde, Nels C., Child, Stephanie J., Eickbush, Michael T., Kitzman, Jacob O., Rogers, Kelsey S., Shendure, Jay, Geballe, Adam P., Malik, Harmit S.

“…In contrast to RNA viruses, double-stranded DNA viruses have low mutation rates yet must still adapt rapidly in response to changing host defenses. To…”
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Rapid adaptation to human protein kinase R by a unique genomic rearrangement in rhesus cytomegalovirus by Child, Stephanie J, Greninger, Alexander L, Geballe, Adam P

“…Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with one host species limits their ability to…”
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Antagonism of Protein Kinase R by Large DNA Viruses by Olson, Annabel T, Child, Stephanie J, Geballe, Adam P

“…Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of…”
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A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists by Carpentier, Kathryn S, Esparo, Nicolle M, Child, Stephanie J, Geballe, Adam P

“…During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses,…”
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Species Specificity of Protein Kinase R Antagonism by Cytomegalovirus TRS1 Genes by Child, Stephanie J, Brennan, Greg, Braggin, Jacquelyn E, Geballe, Adam P

“…Erratum ( vol. 86 , p. 12470 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Binding and Relocalization of Protein Kinase R by Murine Cytomegalovirus by CHILD, Stephanie J, GEBALLE, Adam P

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Evasion of Cellular Antiviral Responses by Human Cytomegalovirus TRS1 and IRS1 by CHILD, Stephanie J, HAKKI, Morgan, DE NIRO, Katherine L, GEBALLE, Adam P

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The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA by Gray, Elizabeth E., Winship, Damion, Snyder, Jessica M., Child, Stephanie J., Geballe, Adam P., Stetson, Daniel B.

“…Detection of intracellular DNA triggers activation of the STING-dependent interferon-stimulatory DNA (ISD) pathway, which is essential for antiviral responses…”
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A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB by Bayer, Avraham, Child, Stephanie J, Malik, Harmit S, Geballe, Adam P

“…Herpesviruses present a major global disease burden. Understanding the host cell mechanisms that block viral infections, as well as how viruses can evolve to…”
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Double-Stranded RNA Binding by a Heterodimeric Complex of Murine Cytomegalovirus m142 and m143 Proteins by CHILD, Stephanie J, HANSON, Laura K, BROWN, Crystal E, JANZEN, Deanna M, GEBALLE, Adam P

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Protein kinase R reveals an evolutionary model for defeating viral mimicry by Malik, Harmit S, Elde, Nels C, Child, Stephanie J, Geballe, Adam P

“…Distinguishing self from non-self is a fundamental biological challenge. Many pathogens exploit the challenge of self discrimination by employing mimicry to…”
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Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus by Child, Stephanie J, Hickson, Sarah E, Bayer, Avraham, Malouli, Daniel, Früh, Klaus, Geballe, Adam P

“…While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from…”
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Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication by Braggin, Jacquelyn E, Child, Stephanie J, Geballe, Adam P

“…Abstract Human cytomegalovirus (HCMV) lacking TRS 1 and IRS 1 (HCMV[Δ I /Δ T ]) cannot replicate in cell culture. Although both proteins can block the protein…”
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Complementation of Vaccinia Virus Lacking the Double-Stranded RNA-Binding Protein Gene E3L by Human Cytomegalovirus by Child, Stephanie J, Jarrahian, Sohail, Harper, Victoria M, Geballe, Adam P

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Translational Control by an Upstream Open Reading Frame in the HER-2/neu Transcript by Child, Stephanie J., Miller, Melanie K., Geballe, Adam P.

“…Overexpression of the HER-2 (neu, erb B-2) receptor results in cellular transformation and is associated with a variety of human cancers. Multiple mechanisms,…”
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Abundant Early Expression of gpUL4 from a Human Cytomegalovirus Mutant Lacking a Repressive Upstream Open Reading Frame by Alderete, J P, Child, S J, Geballe, A P

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Cell type-dependent and -independent control of HER-2/ neu translation by Child, Stephanie J, Miller, Melanie K, Geballe, Adam P

“…Overexpression of the HER-2 oncogene occurs in a variety of human tumors, including 25–30% of breast carcinomas, and has been associated with an adverse…”
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Species Specificity of Protein Kinase R Antagonism by Cytomegalovirus TRS1 Genes by Child, Stephanie J., Brennan, Greg, Braggin, Jacquelyn E., Geballe, Adam P.

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Species Specificity of Protein Kinase R Antagonism by Cytomegalovirus TRS 1 Genes by CHILD, Stephanie J, BRENNAN, Greg, BRAGGIN, Jacquelyn E, GEBALLE, Adam P

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Evidence for multiple species of vaccinia virus-encoded palmitylated proteins by Child, S J, Hruby, D E

“…When cells were infected with vaccinia virus in the presence of [3H]palmitic acid, radiolabel was incorporated into six viral proteins with apparent molecular…”
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