Search Results - "Chikwana, Vimbai M."

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase by Tang, Buyun, Frasinyuk, Mykhaylo S, Chikwana, Vimbai M, Mahalingan, Krishna K, Morgan, Cynthia A, Segvich, Dyann M, Bondarenko, Svitlana P, Mrug, Galyna P, Wyrebek, Przemyslaw, Watt, David S, DePaoli-Roach, Anna A, Roach, Peter J, Hurley, Thomas D

“…The overaccumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease…”
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Structural basis for 2′-phosphate incorporation into glycogen by glycogen synthase by Chikwana, Vimbai M., Khanna, May, Baskaran, Sulochanadevi, Tagliabracci, Vincent S., Contreras, Christopher J., DePaoli-Roach, Anna, Roach, Peter J., Hurley, Thomas D.

“…Glycogen is a glucose polymer that contains minor amounts of covalently attached phosphate. Hyperphosphorylation is deleterious to glycogen structure and can…”
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Multiple Glycogen-binding Sites in Eukaryotic Glycogen Synthase Are Required for High Catalytic Efficiency toward Glycogen by Baskaran, Sulochanadevi, Chikwana, Vimbai M., Contreras, Christopher J., Davis, Keri D., Wilson, Wayne A., DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D.

“…Glycogen synthase is a rate-limiting enzyme in the biosynthesis of glycogen and has an essential role in glucose homeostasis. The three-dimensional structures…”
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Discovery and Characterization of an Amidinotransferase Involved in the Modification of Archaeal tRNA by Phillips, Gabriela, Chikwana, Vimbai M., Maxwell, Adrienne, El-Yacoubi, Basma, Swairjo, Manal A., Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie

“…The presence of the 7-deazaguanosine derivative archaeosine (G+) at position 15 in tRNA is one of the diagnostic molecular characteristics of the Archaea. The…”
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Brain glycogen serves as a critical glucosamine cache required for protein glycosylation by Sun, Ramon C., Young, Lyndsay E.A., Bruntz, Ronald C., Markussen, Kia H., Zhou, Zhengqiu, Conroy, Lindsey R., Hawkinson, Tara R., Clarke, Harrison A., Stanback, Alexandra E., Macedo, Jessica K.A., Emanuelle, Shane, Brewer, M. Kathryn, Rondon, Alberto L., Mestas, Annette, Sanders, William C., Mahalingan, Krishna K., Tang, Buyun, Chikwana, Vimbai M., Segvich, Dyann M., Contreras, Christopher J., Allenger, Elizabeth J., Brainson, Christine F., Johnson, Lance A., Taylor, Richard E., Armstrong, Dustin D., Shaffer, Robert, Waechter, Charles J., Vander Kooi, Craig W., DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D., Drake, Richard R., Gentry, Matthew S.

“…Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In…”
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Queuosine Deficiency in Eukaryotes Compromises Tyrosine Production through Increased Tetrahydrobiopterin Oxidation by Rakovich, Tatsiana, Boland, Coilin, Bernstein, Ilana, Chikwana, Vimbai M., Iwata-Reuyl, Dirk, Kelly, Vincent P.

“…Queuosine is a modified pyrrolopyrimidine nucleoside found in the anticodon loop of transfer RNA acceptors for the amino acids tyrosine, asparagine, aspartic…”
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Incorporation of phosphate into glycogen by glycogen synthase by Contreras, Christopher J., Segvich, Dyann M., Mahalingan, Krishna, Chikwana, Vimbai M., Kirley, Terence L., Hurley, Thomas D., DePaoli-Roach, Anna A., Roach, Peter J.

“…The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues…”
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Structural Basis of Biological Nitrile Reduction by Chikwana, Vimbai M., Stec, Boguslaw, Lee, Bobby W.K., de Crécy-Lagard, Valérie, Iwata-Reuyl, Dirk, Swairjo, Manal A.

“…The enzyme QueF catalyzes the reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), the only nitrile…”
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Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells by Khanna, May, Imasaki, Tsuyoshi, Chikwana, Vimbai M., Perez-Miller, Samantha, Hunter, Gerald O., Mosley, Amber, Takagi, Yuichiro, Hurley, Thomas D.

“…•Human glycogen synthase 1 (hGYS1) is purified by co-expression with glycogenin.•Recombinant hGYS1 produced in insect Hi5 cells is functional.•Recombinant…”
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