Search Results - "Chikhale, Rupesh V"

Unlocking the potential of PROTACs: A comprehensive review of protein degradation strategies in disease therapy by Bhole, Ritesh P., Kute, Payal R., Chikhale, Rupesh V., Bonde, C.G., Pant, Amit, Gurav, Shailendra S.

“…[Display omitted] •PROTACs (PROteolysis TArgeting Chimeras) are a technology used for protein degradation through the use of bifunctional small molecules.•They…”
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Identification of sugar-containing natural products that interact with i-motif DNA by Chikhale, Rupesh V., Guneri, Dilek, Yuan, Robert, Morris, Christopher J., Waller, Zoë A.E.

“…[Display omitted] There are thousands of compounds shown to interact with G-quadruplex DNA, yet very few which target i-motif (iM) DNA. Previous work showed…”
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A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA) by Ambade, Shraddha S., Gupta, Vivek Kumar, Bhole, Ritesh P., Khedekar, Pramod B., Chikhale, Rupesh V.

“…Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic…”
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Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region by Guneri, Dilek, Alexandrou, Effrosyni, El Omari, Kamel, Dvořáková, Zuzana, Chikhale, Rupesh V., Pike, Daniel T. S., Waudby, Christopher A., Morris, Christopher J., Haider, Shozeb, Parkinson, Gary N., Waller, Zoë A. E.

“…The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA in the promoter of the insulin gene that regulates transcription of…”
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Rutin from Begonia roxburghii modulates iNOS and Sep A activity in treatment of Shigella flexneri induced diarrhoea in rats: An in vitro, in vivo and computational analysis by Prasad, Rupali S., Chikhale, Rupesh V., Rai, Nitish, Akojwar, Natasha S., Purohit, Raksha A., Sharma, Pravesh, Kulkarni, Onkar, Laloo, Damiki, Gurav, Shailendra S., Itankar, Prakash R., Prasad, Satyendra K.

“…In developing countries, diarrhoea is a major issue of concern, where consistent use of antibiotics has resulted in several side effects along with development…”
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Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives by Bhole, Ritesh P., Chikhale, Rupesh V., Rathi, Karishma M.

“…Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses a significant public health challenge. Despite…”
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Identification of Mycobacterium tuberculosis transcriptional repressor EthR inhibitors: Shape-based search and machine learning studies by Chikhale, Rupesh V., Eldesoky, Gaber E., Kolpe, Mahima Sudhir, Suryawanshi, Vikramsinh Sardarsinh, Patil, Pritee Chunarkar, Bhowmick, Shovonlal

“…Tuberculosis has been a challenge to the world since prehistoric times, and with the advent of drug-resistant strains, it has become more challenging to treat…”
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Covalent drug – An emerging framework for targeted drug development by Bhole, Ritesh P., Joshi, Govinda O., Kapare, Harshad S., Chikhale, Rupesh V., Chaudhari, Somdatta

“…[Display omitted] •Historical overview traces covalent drugs since the 20th century, spotlighting safety concerns that hindered their…”
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Determination and Pharmacokinetic Study of Pirfenidone in Rat Serum by High-Performance Thin-Layer Chromatography by Thorat, Sonali G., Chikhale, Rupesh V.

“…A rapid, sensitive and selective high-performance thin-layer chromatography (HPTLC) method was developed and validated for the determination and…”
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Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy by Singh, Vibha, Bhoir, Siddhant, Chikhale, Rupesh V., Hussain, Javeena, Dwyer, Donard, Bryce, Richard A., Kirubakaran, Sivapriya, De Benedetti, Arrigo

“…Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory…”
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Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents by Bhole, Ritesh P., Chikhale, Rupesh V., Wavhale, Ravindra D., Asmary, Fatmah Ali, Almutairi, Tahani Mazyad, Alhajri, Hassna Mohammed, Bonde, Chandrakant G.

“…The androgen receptor inhibitor, Enzalutamide, proved effective against castration resistance prostate cancer, has demonstrated clinical benefits and increased…”
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Vitamin-anticancer drug conjugates: A new era for cancer therapy by Bhole,Ritesh, Jadhav,Shradha, Zambare,Yogesh, Chikhale,Rupesh V, Bonde,Chandrakant G

“…Background: Following cardiovascular diseases, cancer is the world's second leading cause of death. Chemotherapy is the conventional gold technique for…”
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Computational and network pharmacology studies of Phyllanthus emblica to tackle SARS-CoV-2 by Chikhale, Rupesh V., Sinha, Saurabh K., Khanal, Pukar, Gurav, Nilambari S., Ayyanar, Muniappan, Prasad, Satyendra K., Wanjari, Manish M., Patil, Rajesh B., Gurav, Shailendra S.

“…•Emblica officinalis is used as rejuvenator in Traditional Systems of Medicine.•Docking, MD and network pharmacology demonstrated antiviral & adjuvant…”
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Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis by Chikhale, Rupesh V, Barmade, Mahesh A, Murumkar, Prashant R, Yadav, Mange Ram

“…Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1), a vital enzyme for cell wall synthesis, plays a crucial role in the formation of lipoarabinomannan and…”
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Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat Tuberculosis by Umare, Mohit D., Khedekar, Pramod B., Chikhale, Rupesh V.

“…Tuberculosis is a prominent aliment throughout the world and a leading cause of mortality among infectious diseases. Drug development for multi‐drug resistance…”
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Mycobacterium enoyl acyl carrier protein reductase (InhA): A key target for antitubercular drug discovery by Prasad, Mayuri S., Bhole, Ritesh P., Khedekar, Pramod B., Chikhale, Rupesh V.

“…[Display omitted] •InhA remains a novel target for development of antitubercular drugs.•High throughput screening and encoded library technology helped…”
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Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease by Khan, Sumbul Fatma, Rathod, Priyanka, Gupta, Vivek K., Khedekar, Pramod B., Chikhale, Rupesh V.

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Identification of potential anti-TMPRSS2 natural products through homology modelling, virtual screening and molecular dynamics simulation studies by Chikhale, Rupesh V., Gupta, Vivek K., Eldesoky, Gaber E., Wabaidur, Saikh M., Patil, Shripad A., Islam, Md Ataul

“…Recent outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a pandemic of COVID-19. The absence of a therapeutic drug and…”
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Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach by Chikhale, Rupesh V., Gurav, Shailendra S., Patil, Rajesh B., Sinha, Saurabh K., Prasad, Satyendra K., Shakya, Anshul, Shrivastava, Sushant K., Gurav, Nilambari S., Prasad, Rupali S.

“…COVID-19 has ravaged the world and is the greatest of pandemics in modern human history, in the absence of treatment or vaccine, the mortality and morbidity…”
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DNA G‑Quadruplex and i‑Motif Structure Formation Is Interdependent in Human Cells by King, Jessica J, Irving, Kelly L, Evans, Cameron W, Chikhale, Rupesh V, Becker, Rouven, Morris, Christopher J, Peña Martinez, Cristian D, Schofield, Peter, Christ, Daniel, Hurley, Laurence H, Waller, Zoë A. E, Iyer, K. Swaminathan, Smith, Nicole M

“…Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show…”
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