Search Results - "Chikashi Terao"

Revisited HLA and non-HLA genetics of Takayasu arteritis--where are we? by Terao, Chikashi

“…Takayasu arteritis (TAK) is an immune-mediated vasculitis affecting large arteries first reported in 1908 from Japan. Case reports of familial onset of TAK…”
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Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing by Kosugi, Shunichi, Momozawa, Yukihide, Liu, Xiaoxi, Terao, Chikashi, Kubo, Michiaki, Kamatani, Yoichiro

“…Structural variations (SVs) or copy number variations (CNVs) greatly impact the functions of the genes encoded in the genome and are responsible for diverse…”
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The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review by Ishikawa, Yuki, Terao, Chikashi

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually…”
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How to conduct research of rare autoimmune diseases by Terao, Chikashi

“…Rare autoimmune diseases are difficult to conduct researches in spite of present era with advanced scientific progress. Research using genetic approach is a…”
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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements by Amariuta, Tiffany, Ishigaki, Kazuyoshi, Sugishita, Hiroki, Ohta, Tazro, Koido, Masaru, Dey, Kushal K., Matsuda, Koichi, Murakami, Yoshinori, Price, Alkes L., Kawakami, Eiryo, Terao, Chikashi, Raychaudhuri, Soumya

“…Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric genetic studies and limited knowledge of shared causal variants…”
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Genetics of autosomal mosaic chromosomal alteration (mCA) by Liu, Xiaoxi, Kamatani, Yoichiro, Terao, Chikashi

“…Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are regarded as one of the common features of cancers. Strikingly,…”
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Chromosomal alterations among age-related haematopoietic clones in Japan by Terao, Chikashi, Suzuki, Akari, Momozawa, Yukihide, Akiyama, Masato, Ishigaki, Kazuyoshi, Yamamoto, Kazuhiko, Matsuda, Koichi, Murakami, Yoshinori, McCarroll, Steven A., Kubo, Michiaki, Loh, Po-Ru, Kamatani, Yoichiro

“…The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with…”
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Genetic analysis of IgG4-related disease by Ishikawa, Yuki, Terao, Chikashi

“…IgG4-related disease (IgG4-RD) is an emerging concept of a novel clinical entity, characterized by the swelling of the affected organs, increase in serum total…”
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Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer by Usui, Yoshiaki, Taniyama, Yukari, Endo, Mikiko, Koyanagi, Yuriko N., Kasugai, Yumiko, Oze, Isao, Ito, Hidemi, Imoto, Issei, Tanaka, Tsutomu, Tajika, Masahiro, Niwa, Yasumasa, Iwasaki, Yusuke, Aoi, Tomomi, Hakozaki, Nozomi, Takata, Sadaaki, Suzuki, Kunihiko, Terao, Chikashi, Hatakeyama, Masanori, Hirata, Makoto, Sugano, Kokichi, Yoshida, Teruhiko, Kamatani, Yoichiro, Nakagawa, Hidewaki, Matsuda, Koichi, Murakami, Yoshinori, Spurdle, Amanda B., Matsuo, Keitaro, Momozawa, Yukihide

“…Infection with Helicobacter pylori is known to confer a risk of gastric cancer. In this study, persons who carried certain genetic variants and were infected…”
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Eight novel susceptibility loci and putative causal variants in atopic dermatitis by Tanaka, Nao, Koido, Masaru, Suzuki, Akari, Otomo, Nao, Suetsugu, Hiroyuki, Kochi, Yuta, Tomizuka, Kouhei, Momozawa, Yukihide, Kamatani, Yoichiro, Ikegawa, Shiro, Yamamoto, Kazuhiko, Terao, Chikashi

“…Atopic dermatitis (AD) is the most common allergic disease in the world. While genetic components play critical roles in its pathophysiology, a large…”
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Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection by Zekavat, Seyedeh M., Lin, Shu-Hong, Bick, Alexander G., Liu, Aoxing, Paruchuri, Kaavya, Wang, Chen, Uddin, Md Mesbah, Ye, Yixuan, Yu, Zhaolong, Liu, Xiaoxi, Kamatani, Yoichiro, Bhattacharya, Romit, Pirruccello, James P., Pampana, Akhil, Loh, Po-Ru, Kohli, Puja, McCarroll, Steven A., Kiryluk, Krzysztof, Neale, Benjamin, Ionita-Laza, Iuliana, Engels, Eric A., Brown, Derek W., Smoller, Jordan W., Green, Robert, Karlson, Elizabeth W., Lebo, Matthew, Ellinor, Patrick T., Weiss, Scott T., Daly, Mark J., Terao, Chikashi, Zhao, Hongyu, Ebert, Benjamin L., Reilly, Muredach P., Ganna, Andrea, Machiela, Mitchell J., Genovese, Giulio, Natarajan, Pradeep

“…Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related…”
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Comparative evaluation of SNVs, indels, and structural variations detected with short- and long-read sequencing data by Kosugi, Shunichi, Terao, Chikashi

“…Short- and long-read sequencing technologies are routinely used to detect DNA variants, including SNVs, indels, and structural variations (SVs). However, the…”
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Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis by Suzuki, Akari, Terao, Chikashi, Yamamoto, Kazuhiko

“…Rheumatoid arthritis (RA) is an autoimmune disease of unknown pathologic mechanism. Extensive single-level analyses have been conducted, including genome-wide…”
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A case of retinitis pigmentosa homozygous for a rare CNGA1 causal variant by Saito, Kohei, Gotoh, Norimoto, Kang, Inyeop, Shimada, Toshio, Usui, Takeshi, Terao, Chikashi

“…Retinitis pigmentosa (RP) is a heterogenous hereditary disorder leading to blindness. Despite using next-generation sequencing technologies, causal variants in…”
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Genetic variants of calcium and vitamin D metabolism in kidney stone disease by Howles, Sarah A., Wiberg, Akira, Goldsworthy, Michelle, Bayliss, Asha L., Gluck, Anna K., Ng, Michael, Grout, Emily, Tanikawa, Chizu, Kamatani, Yoichiro, Terao, Chikashi, Takahashi, Atsushi, Kubo, Michiaki, Matsuda, Koichi, Thakker, Rajesh V., Turney, Benjamin W., Furniss, Dominic

“…Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a heritability of ~45–60%. We present genome-wide association…”
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Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus by Yin, Xianyong, Kim, Kwangwoo, Suetsugu, Hiroyuki, Bang, So-Young, Wen, Leilei, Koido, Masaru, Ha, Eunji, Liu, Lu, Sakamoto, Yuma, Jo, Sungsin, Leng, Rui-Xue, Otomo, Nao, Laurynenka, Viktoryia, Kwon, Young-Chang, Sheng, Yujun, Sugano, Nobuhiko, Hwang, Mi Yeong, Li, Weiran, Mukai, Masaya, Yoon, Kyungheon, Cai, Minglong, Ishigaki, Kazuyoshi, Chung, Won Tae, Huang, He, Takahashi, Daisuke, Lee, Shin-Seok, Wang, Mengwei, Karino, Kohei, Shim, Seung-Cheol, Zheng, Xiaodong, Miyamura, Tomoya, Kang, Young Mo, Ye, Dongqing, Nakamura, Junichi, Suh, Chang-Hee, Tang, Yuanjia, Motomura, Goro, Park, Yong-Beom, Ding, Huihua, Kuroda, Takeshi, Choe, Jung-Yoon, Li, Chengxu, Niiro, Hiroaki, Park, Youngho, Shen, Changbing, Miyamoto, Takeshi, Ahn, Ga-Young, Fei, Wenmin, Takeuchi, Tsutomu, Shin, Jung-Min, Li, Keke, Kawaguchi, Yasushi, Lee, Yeon-Kyung, Wang, Yongfei, Amano, Koichi, Park, Dae Jin, Yang, Wanling, Tada, Yoshifumi, Yamaji, Ken, Shimizu, Masato, Atsumi, Takashi, Suzuki, Akari, Sumida, Takayuki, Okada, Yukinori, Matsuda, Koichi, Matsuo, Keitaro, Kochi, Yuta, Kottyan, Leah C, Weirauch, Matthew T, Parameswaran, Sreeja, Eswar, Shruti, Salim, Hanan, Chen, Xiaoting, Yamamoto, Kazuhiko, Harley, John B, Ohmura, Koichiro, Kim, Tae-Hwan, Yang, Sen, Yamamoto, Takuaki, Kim, Bong-Jo, Shen, Nan, Ikegawa, Shiro, Lee, Hye-Soon, Zhang, Xuejun, Terao, Chikashi, Cui, Yong, Bae, Sang-Cheol

“…Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially…”
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Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis by Torii, Mie, Hashimoto, Motomu, Hanai, Akiko, Fujii, Takao, Furu, Moritoshi, Ito, Hiromu, Uozumi, Ryuji, Hamaguchi, Masahide, Terao, Chikashi, Yamamoto, Wataru, Uda, Miyabi, Nin, Kazuko, Morita, Satoshi, Arai, Hidenori, Mimori, Tsuneyo

“…Objectives: Sarcopenia is characterized by loss of muscle strength and mass, leading to falls and adverse health outcomes. Our aim was to determine the…”
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Functional annotation of human long noncoding RNAs via molecular phenotyping by Ramilowski, Jordan A, Yip, Chi Wai, Agrawal, Saumya, Chang, Jen-Chien, Ciani, Yari, Kulakovskiy, Ivan V, Mendez, Mickaël, Ooi, Jasmine Li Ching, Ouyang, John F, Parkinson, Nick, Petri, Andreas, Roos, Leonie, Severin, Jessica, Yasuzawa, Kayoko, Abugessaisa, Imad, Akalin, Altuna, Antonov, Ivan V, Arner, Erik, Bonetti, Alessandro, Bono, Hidemasa, Borsari, Beatrice, Brombacher, Frank, Cameron, Christopher JF, Cannistraci, Carlo Vittorio, Cardenas, Ryan, Cardon, Melissa, Chang, Howard, Dostie, Josée, Ducoli, Luca, Favorov, Alexander, Fort, Alexandre, Garrido, Diego, Gil, Noa, Gimenez, Juliette, Guler, Reto, Handoko, Lusy, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Kosuke, Hayatsu, Norihito, Heutink, Peter, Hirose, Tetsuro, Imada, Eddie L, Itoh, Masayoshi, Kaczkowski, Bogumil, Kanhere, Aditi, Kawabata, Emily, Kawaji, Hideya, Kawashima, Tsugumi, Kelly, S Thomas, Kojima, Miki, Kondo, Naoto, Koseki, Haruhiko, Kouno, Tsukasa, Kratz, Anton, Kurowska-Stolarska, Mariola, Kwon, Andrew Tae Jun, Leek, Jeffrey, Lennartsson, Andreas, Lizio, Marina, López-Redondo, Fernando, Luginbühl, Joachim, Maeda, Shiori, Makeev, Vsevolod J, Marchionni, Luigi, Medvedeva, Yulia A, Minoda, Aki, Müller, Ferenc, Muñoz-Aguirre, Manuel, Murata, Mitsuyoshi, Nishiyori, Hiromi, Nitta, Kazuhiro R, Noguchi, Shuhei, Noro, Yukihiko, Nurtdinov, Ramil, Okazaki, Yasushi, Orlando, Valerio, Paquette, Denis, Parr, Callum J C, Rackham, Owen J L, Rizzu, Patrizia, Sánchez Martinez, Diego Fernando, Sandelin, Albin, Sanjana, Pillay, Semple, Colin A M, Shibayama, Youtaro, Sivaraman, Divya M, Suzuki, Takahiro, Szumowski, Suzannah C, Tagami, Michihira, Taylor, Martin S, Terao, Chikashi, Thodberg, Malte, Thongjuea, Supat, Tripathi, Vidisha, Ulitsky, Igor, Verardo, Roberto, Vorontsov, Ilya E, Yamamoto, Chinatsu

“…Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the…”
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Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis by Saiki, Ryunosuke, Momozawa, Yukihide, Nannya, Yasuhito, Nakagawa, Masahiro M., Ochi, Yotaro, Yoshizato, Tetsuichi, Terao, Chikashi, Kuroda, Yutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Niida, Atsushi, Imoto, Seiya, Matsuda, Koichi, Morisaki, Takayuki, Murakami, Yoshinori, Kamatani, Yoichiro, Matsuda, Shuichi, Kubo, Michiaki, Miyano, Satoru, Makishima, Hideki, Ogawa, Seishi

“…Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases…”
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A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis by Kadoba, Keiichiro, Watanabe, Ryu, Iwasaki, Takeshi, Nakajima, Toshiki, Kitagori, Koji, Akizuki, Shuji, Murakami, Kosaku, Nakashima, Ran, Hashimoto, Motomu, Tanaka, Masao, Ohmura, Koichiro, Morinobu, Akio, Terao, Chikashi, Yoshifuji, Hajime

“…HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3…”
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