Search Results - "Chihade, Joseph"

When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases by González-Serrano, Ligia Elena, Chihade, Joseph W., Sissler, Marie

“…Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are essential components of the mitochondrial translation machinery. The correlation of mitochondrial…”
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Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs by Kuhle, Bernhard, Chihade, Joseph, Schimmel, Paul

“…Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong…”
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Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria by Hilander, Taru, Zhou, Xiao-Long, Konovalova, Svetlana, Zhang, Fu-Ping, Euro, Liliya, Chilov, Dmitri, Poutanen, Matti, Chihade, Joseph, Wang, En-Duo, Tyynismaa, Henna

“…Abstract Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced…”
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COVID-360: A Collaborative Effort to Develop a Multidisciplinary Set of Online Resources for Engaging Teaching on the COVID-19 Pandemic by Moore, Victoria Del Gaizo, Scheifele, Lisa Z, Chihade, Joseph W, Provost, Joseph J, Roecklein-Canfield, Jennifer A, Tsotakos, Nikolaos, Wolyniak, Michael J

“…The COVID-19 pandemic has challenged undergraduate instructors and students in an unprecedented manner. Each has needed to find creative ways to continue the…”
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Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation by Euro, Liliya, Konovalova, Svetlana, Asin-Cayuela, Jorge, Tulinius, Már, Griffin, Helen, Horvath, Rita, Taylor, Robert W, Chinnery, Patrick F, Schara, Ulrike, Thorburn, David R, Suomalainen, Anu, Chihade, Joseph, Tyynismaa, Henna

“…The accuracy of mitochondrial protein synthesis is dependent on the coordinated action of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mtARSs) and…”
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Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids by Hati, Sanchita, Ziervogel, Brigitte, Sternjohn, Julius, Wong, Fai-Chu, Nagan, Maria C, Rosen, Abbey E, Siliciano, Paul G, Chihade, Joseph W, Musier-Forsyth, Karin

“…Aminoacyl-tRNA synthetases catalyze the attachment of cognate amino acids to specific tRNA molecules. To prevent potential errors in protein synthesis caused…”
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Mitochondrial aminoacyl-tRNA synthetases by Chihade, Joseph

“…In all eukaryotic cells, protein synthesis occurs not only in the cytosol, but also in the mitochondria. Translation of mitochondrial genes requires a set of…”
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Abstract 2035: Towards bacterial expression of helminth mitochondrial aminoacyl-tRNA synthetases by Mueller, Noah, Abraha, Sara, Chihade, Joseph

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A streamlined molecular biology module for undergraduate biochemistry labs by Muth, Gregory W., Chihade, Joseph W.

“…Site‐directed mutagenesis and other molecular biology techniques, including plasmid manipulation and restriction analysis, are commonly used tools in the…”
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Abstract 1744 Bacterial expression of helminth aminoacyl-tRNA synthetases by Nelson, Jack, Abraha, Sara, Mueller, Noah, Chihade, Joseph

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Abstract 2055: Bacterial expression of unstable mutants of a human mitochondrial aminoacyl-tRNA synthetase by Bayene, Eledon, Klay, Meredith, Nair, Shreya, Randa, Lora, Chihade, Joseph

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Translocation within the acceptor helix of a major tRNA identity determinant by Lovato, Martha A., Chihade, Joseph W., Schimmel, Paul

“…The genetic code is defined by the specific aminoacylations of tRNAs by aminoacyl‐tRNA synthetases. Although the synthetases are widely conserved through…”
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Towards Bacterial Expression of Unstable Mutants of a Mitochondrial Enzyme by Randa, Lora, Beyene, Eledon, Gjertson, Max, Chihade, Joseph

“…Mutations in the human AARS2 gene, which codes for the mitochondrial alanyl‐tRNA synthetase, are linked with severe disease, including infantile cardiomyopathy…”
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Expression and Characterization of Helminthic Aminoacyl‐tRNA Synthetases by Wilson, David, Kammann, Molly, Qi, Leo, Williams, Augustus, Chihade, Joseph

“…Parasitic worms, broadly described as helminths, currently infect approximately 2 billion people worldwide. Existing treatment options are limited and many…”
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Abstract 1804 Extending the scope of a coupled assay to measure alanyl-tRNA synthetase activity by Munro, Katie, Salgado, Lizzet Solache, Qi, Leo, Williams, Augustus, Chihade, Joseph

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Origin of Mitochondria in Relation to Evolutionary History of Eukaryotic Alanyl-tRNA Synthetase by Chihade, Joseph W., Brown, James R., Schimmel, Paul R., de Pouplana, Lluis Ribas

“…The origin of the eukaryotic cell remains an unsolved question. Numerous experimental and phylogenetic observations support the symbiotic origin of the modern…”
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Assembly of a Catalytic Unit for RNA Microhelix Aminoacylation Using Nonspecific RNA Binding Domains by Chihade, Joseph W., Schimmel, Paul

“…An assembly of a catalytic unit for aminoacylation of an RNA microhelix is demonstrated here. This assembly may recapitulate a step in the historical…”
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Pathogenic Mutations in a Human Mitochondrial Enzyme Affect Protein Stability by Kennicott, Hannah, McCurdy, Clara, Makori, Jessica, Chihade, Joseph

“…Mutations in human mitochondrial alanyl tRNA‐synthetase have been correlated with at least two different pathologies, infantile cardiomyopathy and…”
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Towards a New Aminoacylation Assay for Alanyl‐tRNA Synthetases by Duplessis, Kyle, Heath, Jacob, McCarthy, Ian, Chihade, Joseph

“…Aminoacyl‐tRNA synthetases are crucial enzymes in protein biosynthesis, ensuring the fidelity of the genetic code by charging transfer RNAs with the…”
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Improving Prediction of Helminth Aminoacyl‐tRNA Synthetases through Manual Analysis of Genomic Data by Block, Alison, Gjertson, Max, Robinson, Jevon, Warner, Seth, Wilson, David, Chihade, Joseph

“…Helminth is a generic term for the parasitic worms that negatively impact health outcomes for a roughly a quarter of the global population. Although more than…”
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