Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specifi c activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the conte...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 149; no. 1; pp. 82 - 85
Main Authors: Spirina, L. V, Kondakova, I. V, Choinzonov, E. L, Sharova, N. P, Chigevskay, S. Y, Shishkin, D. A
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-07-2010
Springer US
Springer
Springer Nature B.V
Subjects:
Biomedical and Life Sciences
Biomedicine
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - pathology
Cell Biology
Chemical Fractionation
Electrophoresis, Polyacrylamide Gel
Fluorometry
Head and Neck Neoplasms - enzymology
Head and Neck Neoplasms - pathology
head and neck squamous cell carcinomas
Humans
Internal Medicine
Laboratory Medicine
Middle Aged
Pathology
proteasomal regulators
Proteasome Endopeptidase Complex - metabolism
proteasome immune subunits
proteasomes
Proteolysis
Squamous cell carcinoma
Statistics, Nonparametric
Tumors
proteasome immune subunits
head and neck squamous cell carcinomas
proteasomal regulators
proteasomes
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Summary:The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specifi c activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory proteasomal complex PA28. In the presence of regional metastases, 26S proteasome activity decreases and the content of proteasome immune subunit LMP7 in the tumor increases.
Bibliography:http://dx.doi.org/10.1007/s10517-010-0881-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0881-8