Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients

Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients

In this short report, we describe an outbreak of COVID-19 caused by Omicron subvariant BA.5.2.1 in highly vaccinated patients in a respiratory ward in a large acute general hospital in North West London, United Kingdom. The attack rate was high (14/33 (42%)) but the clinical impact was relatively no...

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Bibliographic Details
Published in:Epidemiology and infection Vol. 151; p. e171
Main Authors: Gopal Rao, Guduru, Jinjika, Shamiso, James, Dianne, Mukombe, Nyarayi, Patel, Bharat, Chietcheu, Amelie, Macmanus, Christine, Adeboyeku, David, Davies, Emma, Brown, Benjamin
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 26-09-2023
Subjects:
COVID-19
COVID-19 vaccines
Disease control
Disease transmission
Epidemics
Health risks
Hospitals
Mutation
Nosocomial infection
Nosocomial infections
Outbreaks
Pandemics
Patients
Phylogenetics
Pneumonitis
Public health
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Short Paper
Vaccination
Ventilation
Viral diseases
United Kingdom > UK
England
COVID-19
vaccines
outbreaks
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Summary:In this short report, we describe an outbreak of COVID-19 caused by Omicron subvariant BA.5.2.1 in highly vaccinated patients in a respiratory ward in a large acute general hospital in North West London, United Kingdom. The attack rate was high (14/33 (42%)) but the clinical impact was relatively non-severe including in patients who were at high risk of severe COVID-19. Twelve of fourteen patients had COVID-19 vaccinations. There was only one death due to COVID-19 pneumonitis. The findings of this outbreak investigation suggest that while the transmissibility of Omicron BA.5.2.1 subvariant is high, infections caused by this strain are non-severe in vaccinated patients, even if they are at high risk of severe COVID-19 infection.
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ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268823001590