Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion

Abstract Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how t...

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Bibliographic Details
Published in:	Cerebral cortex (New York, N.Y. 1991) Vol. 32; no. 12; pp. 2668 - 2687
Main Authors:	West, Sarah L, Aronson, Justin D, Popa, Laurentiu S, Feller, Kathryn D, Carter, Russell E, Chiesl, William M, Gerhart, Morgan L, Shekhar, Aditya C, Ghanbari, Leila, Kodandaramaiah, Suhasa B, Ebner, Timothy J
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 07-06-2022
Subjects:	Animals Brain Mapping Calcium Diagnostic Imaging Locomotion Magnetic Resonance Imaging Mice Motor Cortex - diagnostic imaging Motor Cortex - physiology Neural Pathways - diagnostic imaging Neural Pathways - physiology Original brain states independent components secondary motor cortex functional connectivity retrosplenial cortex
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Summary:	Abstract Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these functional interactions change with behavioral state. Mesoscopic Ca2+ imaging through transparent polymer skulls in mice reveals elevated activation of the dorsal cerebral cortex during locomotion. Using the correlations between the time series of Ca2+ fluorescence from 28 regions (nodes) obtained using spatial independent component analysis (sICA), we examined the changes in functional connectivity of the cortex from rest to locomotion with a goal of understanding the changes to the cortical functional state that facilitate locomotion. Both the transitions from rest to locomotion and from locomotion to rest show marked increases in correlation among most nodes. However, once a steady state of continued locomotion is reached, many nodes, including primary motor and somatosensory nodes, show decreases in correlations, while retrosplenial and the most anterior nodes of the secondary motor cortex show increases. These results highlight the changes in functional connectivity in the cerebral cortex, representing a series of changes in the cortical state from rest to locomotion and on return to rest.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1047-3211 1460-2199 1460-2199
DOI:	10.1093/cercor/bhab373