Search Results - "Chien Lye, David"

Testing for SARS-CoV-2: Can We Stop at 2? by Lee, Tau Hong, Junhao Lin, Ray, Lin, Raymond T P, Barkham, Timothy, Rao, Pooja, Leo, Yee-Sin, Chien Lye, David, Young, Barnaby

“…Abstract The COVID-19 epidemic requires accurate identification and isolation of confirmed cases for effective control. This report describes the effectiveness…”
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Differentiating coronavirus disease 2019 (COVID-19) from influenza and dengue by Thein, Tun-Linn, Ang, Li Wei, Young, Barnaby Edward, Chen, Mark I-Cheng, Leo, Yee-Sin, Lye, David Chien Boon

“…The novel coronavirus disease 2019 (COVID-19) presents with non-specific clinical features. This may result in misdiagnosis or delayed diagnosis, and lead to…”
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Assessing Viral Shedding and Infectivity of Tears in Coronavirus Disease 2019 (COVID-19) Patients by Seah, Ivan Yu Jun, Anderson, Danielle E., Kang, Adrian Eng Zheng, Wang, Linfa, Rao, Pooja, Young, Barnaby Edward, Lye, David Chien, Agrawal, Rupesh

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Higher rates of carbapenem‐related seizures in older hospitalised adults by Neo, Han‐Yee, Tan, Keng‐Teng, Caroline, Caroline, Wei‐Han Ng, David, Pei‐Ying Ho, Esther, Lim, Jun‐Pei, Hsien‐Xiong Lee, Raphael, Choon‐Kiat Tan, Nigel, Chien‐Boon Lye, David, Ding, Yew‐Yoong

“…Clinical experience suggests higher occurrence of carbapenem‐associated seizures in the elderly than what is reported in the available literature (range…”
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Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore by Young, Barnaby Edward, Ong, Sean Wei Xiang, Kalimuddin, Shirin, Low, Jenny G, Tan, Seow Yen, Loh, Jiashen, Ng, Oon-Tek, Marimuthu, Kalisvar, Ang, Li Wei, Mak, Tze Minn, Lau, Sok Kiang, Anderson, Danielle E, Chan, Kian Sing, Tan, Thean Yen, Ng, Tong Yong, Cui, Lin, Said, Zubaidah, Kurupatham, Lalitha, Chen, Mark I-Cheng, Chan, Monica, Vasoo, Shawn, Wang, Lin-Fa, Tan, Boon Huan, Lin, Raymond Tzer Pin, Lee, Vernon Jian Ming, Leo, Yee-Sin, Lye, David Chien

“…IMPORTANCE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019 and has spread globally with sustained…”
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Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail by Hansen, Johanna, Baum, Alina, Pascal, Kristen E, Russo, Vincenzo, Giordano, Stephanie, Wloga, Elzbieta, Fulton, Benjamin O, Yan, Ying, Koon, Katrina, Patel, Krunal, Chung, Kyung Min, Hermann, Aynur, Ullman, Erica, Cruz, Jonathan, Rafique, Ashique, Huang, Tammy, Fairhurst, Jeanette, Libertiny, Christen, Malbec, Marine, Lee, Wen-Yi, Welsh, Richard, Farr, Glen, Pennington, Seth, Deshpande, Dipali, Cheng, Jemmie, Watty, Anke, Bouffard, Pascal, Babb, Robert, Levenkova, Natasha, Chen, Calvin, Zhang, Bojie, Romero Hernandez, Annabel, Saotome, Kei, Zhou, Yi, Franklin, Matthew, Sivapalasingam, Sumathi, Lye, David Chien, Weston, Stuart, Logue, James, Haupt, Robert, Frieman, Matthew, Chen, Gang, Olson, William, Murphy, Andrew J, Stahl, Neil, Yancopoulos, George D, Kyratsous, Christos A

“…Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments…”
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Protective immunity of SARS-CoV-2 infection and vaccines against medically attended symptomatic omicron BA.4, BA.5, and XBB reinfections in Singapore: a national cohort study by Tan, Celine Y, Chiew, Calvin J, Pang, Deanette, Lee, Vernon J, Ong, Benjamin, Lye, David Chien, Tan, Kelvin Bryan

“…Despite a large proportion of the population having been vaccinated and infected, Singapore had SARS-CoV-2 waves driven by the BA.5 and XBB sublineages of the…”
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Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes by Ong, Sean Wei Xiang, Young, Barnaby Edward, Lye, David Chien

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Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta) by Ong, Sean Wei Xiang, Chiew, Calvin J, Ang, Li Wei, Mak, Tze Minn, Cui, Lin, Toh, Matthias Paul H S, Lim, Yi Ding, Lee, Pei Hua, Lee, Tau Hong, Chia, Po Ying, Maurer-Stroh, Sebastian, Lin, Raymond T P, Leo, Yee Sin, Lee, Vernon J, Lye, David Chien, Young, Barnaby Edward

“…Abstract Background The impact of SARS-CoV-2 variants of concern (VOCs) on disease severity is unclear. In this retrospective study, we compared the outcomes…”
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Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study by Chia, Po Ying, Ong, Sean Wei Xiang, Chiew, Calvin J., Ang, Li Wei, Chavatte, Jean-Marc, Mak, Tze-Minn, Cui, Lin, Kalimuddin, Shirin, Chia, Wan Ni, Tan, Chee Wah, Chai, Louis Yi Ann, Tan, Seow Yen, Zheng, Shuwei, Lin, Raymond Tzer Pin, Wang, Linfa, Leo, Yee-Sin, Lee, Vernon J., Lye, David Chien, Young, Barnaby Edward

“…Highly effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed but variants of concerns are worrisome,…”
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Serological response to trivalent inactivated influenza vaccine in HIV-infected adults in Singapore by Lau, Yuk-Fai, Tang, Lay-Hoon, Chien Lye, David, Ooi, Eng-Eong, Leo, Yee-Sin

“…A cohort of 81 HIV-infected participants received seasonal trivalent inactivated influenza vaccine (TIV) and their humoral responses were monitored using…”
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Contemporary narrative review of treatment options for COVID‐19 by Shang, Lianhan, Lye, David Chien, Cao, Bin

“…The coronavirus disease 2019 (COVID‐19) pandemic is ongoing and many drugs have been studied in clinical trials. From a pathophysiological perspective,…”
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Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 by Carissimo, Guillaume, Xu, Weili, Kwok, Immanuel, Abdad, Mohammad Yazid, Chan, Yi-Hao, Fong, Siew-Wai, Puan, Kia Joo, Lee, Cheryl Yi-Pin, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Chee, Rhonda Sin-Ling, How, Wilson, Chan, Stephrene, Fan, Bingwen Eugene, Andiappan, Anand Kumar, Lee, Bernett, Rötzschke, Olaf, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David Chien, Renia, Laurent, Ng, Lai Guan, Larbi, Anis, Ng, Lisa FP

“…SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected…”
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First report of emergence of OXA-48 carbapenemase-producing Enterobacteriaceae in Singapore: Proactive or reactive infection control strategy? by Marimuthu, Kalisvar, MBBS, MRCP, FAMS, Teo, Jeanette W.P., PhD, Fong, Poh Bee, BSc, Hui Chin, Jani Ong, BSc, Qi, Kum Jia, BSc, Chien Boon, David Lye, FRACP, Li Ping, Angela Chow, MD, MPH, Krishnan, Prabha, MD, FRCPath, Sze Peng, Brenda Ang, MD, MPH

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Effectiveness of bivalent mRNA vaccines against medically attended symptomatic SARS-CoV-2 infection and COVID-19-related hospital admission among SARS-CoV-2-naive and previously infected individuals: a retrospective cohort study by Tan, Celine Y, Chiew, Calvin J, Pang, Deanette, Lee, Vernon J, Ong, Benjamin, Wang, Lin-Fa, Ren, Ee Chee, Lye, David Chien, Tan, Kelvin Bryan

“…Emergence of the SARS-CoV-2 omicron (B.1.1.529) variant with high immune evasion has led to the development and roll-out of bivalent mRNA vaccines targeting…”
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Effectiveness of primary series and booster vaccination against SARS-CoV-2 infection and hospitalisation among adolescents aged 12–17 years in Singapore: a national cohort study by Chiew, Calvin J, Premikha, M, Chong, Chia Yin, Wei, Wycliffe E, Ong, Benjamin, Lye, David Chien, Heng, Derrick, Lee, Vernon J, Tan, Kelvin Bryan

“…Singapore offered the BNT162b2 vaccine (tozinameran; Pfizer-BioNTech) to adolescents aged 12–17 years in May 18, 2021, and extended booster vaccines to this…”
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Effectiveness of a Fourth Dose of COVID-19 mRNA Vaccine Against Omicron Variant Among Elderly People in Singapore by Tan, Celine Y, Chiew, Calvin J, Lee, Vernon J, Ong, Benjamin, Lye, David Chien, Tan, Kelvin Bryan

“…Tan et al discuss a study which aims to estimate the effectiveness of a fourth mRNA vaccine dose against symptomatic SARS-CoV-2 infection, COVID-19-related…”
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Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2 by Su, Yvonne C F, Anderson, Danielle E, Young, Barnaby E, Linster, Martin, Zhu, Feng, Jayakumar, Jayanthi, Zhuang, Yan, Kalimuddin, Shirin, Low, Jenny G H, Tan, Chee Wah, Chia, Wan Ni, Mak, Tze Minn, Octavia, Sophie, Chavatte, Jean-Marc, Lee, Raphael T C, Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Yan, Gabriel Z, Maurer-Stroh, Sebastian, Mendenhall, Ian H, Leo, Yee-Sin, Lye, David Chien, Wang, Lin-Fa, Smith, Gavin J D

“…To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome have been described. Here, we report a…”
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Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates by Chng, Melissa Hui Yen, Lim, Mei Qiu, Rouers, Angeline, Becht, Etienne, Lee, Bernett, MacAry, Paul A., Lye, David Chien, Leo, Yee Sin, Chen, Jinmiao, Fink, Katja, Rivino, Laura, Newell, Evan W.

“…T cells play important multifaceted roles during dengue infection, and understanding their responses is important for defining correlates of protective…”
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In vitro vaccine challenge of PBMCs from BNT162b2 anaphylaxis patients reveals HSP90α‐NOD2‐NLRP3 nexus by Ko, Hui Ling, Zhuo, Nicole, Chang, Zi Wei, Santosa, Anindita, Kalimuddin, Shirin, Lim, Xin Rong, Tan, Seow Yen, Lye, David Chien, Toh, Dorothy, Young, Barnaby Edward, Renia, Laurent, Lee, Haur Yueh, Ren, Ee Chee

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