Search Results - "Chibout, Salah‐Dine"

TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis by Arbués, Ainhoa, Brees, Dominique, Chibout, Salah-Dine, Fox, Todd, Kammüller, Michael, Portevin, Damien

“…TNF-α- as well as non-TNF-α-targeting biologics are prescribed to treat a variety of immune-mediated inflammatory disorders. The well-documented risk of…”
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Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury by Dieterle, Frank, Perentes, Elias, Cordier, André, Roth, Daniel R, Verdes, Pablo, Grenet, Olivier, Pantano, Serafino, Moulin, Pierre, Wahl, Daniel, Mahl, Andreas, End, Peter, Staedtler, Frank, Legay, François, Carl, Kevin, Laurie, David, Chibout, Salah-Dine, Vonderscher, Jacky, Maurer, Gérard

“…Current biomarkers for detecting kidney damage, such as serum creatinine (SCr) and blood urea nitrogen (BUN), lack the sensitivity needed for use in drug…”
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Unaltered hepatic wound healing response in male rats with ancestral liver injury by Beil, Johanna, Perner, Juliane, Pfaller, Lena, Gérard, Marie-Apolline, Piaia, Alessandro, Doelemeyer, Arno, Wasserkrug Naor, Adi, Martin, Lori, Piequet, Aline, Dubost, Valérie, Chibout, Salah-Dine, Moggs, Jonathan, Terranova, Rémi

“…The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of…”
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Inhibition of IL‐17A by secukinumab shows no evidence of increased Mycobacterium tuberculosis infections by Kammüller, Michael, Tsai, Tsen‐Fang, Griffiths, Christopher EM, Kapoor, Nidhi, Kolattukudy, Pappachan E, Brees, Dominique, Chibout, Salah‐Dine, Safi, Jorge, Fox, Todd

“…Secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin‐17A (IL‐17A), has been shown to have significant efficacy in the…”
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Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment by Germano, Davide, Uteng, Marianne, Pognan, Francois, Chibout, Salah-Dine, Wolf, Armin

“…•Multiple addition of Matrigel™ maintains hepatocyte functions for 14days.•14-Day repeated treatments with non-cytotoxic doses mimic chronic…”
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Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease by Sinnaeve, Peter R, Donahue, Mark P, Grass, Peter, Seo, David, Vonderscher, Jacky, Chibout, Salah-Dine, Kraus, William E, Sketch, Jr, Michael, Nelson, Charlotte, Ginsburg, Geoffrey S, Goldschmidt-Clermont, Pascal J, Granger, Christopher B

“…Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene…”
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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion by Lempiäinen, Harri, Couttet, Philippe, Bolognani, Federico, Müller, Arne, Dubost, Valérie, Luisier, Raphaëlle, Del Rio Espinola, Alberto, Vitry, Veronique, Unterberger, Elif B, Thomson, John P, Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Giudicelli, Fanny, Braeuning, Albert, Morawiec, Laurent, Zamurovic, Natasa, Längle, Ulrich, Scheer, Nico, Schübeler, Dirk, Goodman, Jay, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David J, Grenet, Olivier, Zell, Andreas, Templin, Markus F, Meehan, Richard R, Wolf, Roland C, Elcombe, Clifford R, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G

“…The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of…”
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Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human by Pognan, Francois, Mahl, J. Andreas, Papoutsi, Maria, Ledieu, David, Raccuglia, Marc, Theil, Diethilde, Voytek, Sarah B., Devine, Patrick J., Kubek-Luck, Katie, Claudio, Natalie, Cordier, Andre, Heier, Annabelle, Kolly, Carine, Hartmann, Andreas, Chibout, Salah-Dine, Bouchard, Page, Trendelenburg, Christian

“…A high incidence of hemangiosarcoma (HSA) was observed in mice treated for 2 years with siponimod, a sphingosine-1-phosphate receptor 1 (S1P1) functional…”
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T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia by Rubic-Schneider, Tina, Kuwana, Masataka, Christen, Brigitte, Aßenmacher, Manuela, Hainzl, Otmar, Zimmermann, Frank, Fischer, Robert, Koppenburg, Vera, Chibout, Salah-Dine, Wright, Timothy M., Seidl, Andreas, Kammüller, Michael

“…Immunogenicity of biotherapeutics and the elicitation of anti-drug antibodies are a key concern for their efficacy, pharmacokinetics, and safety. A…”
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Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome by Brasa, Sarah, Mueller, Arne, Jacquemont, Sébastien, Hahne, Florian, Rozenberg, Izabela, Peters, Thomas, He, Yunsheng, McCormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar, Terranova, Rémi

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation…”
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Role of innovation in pharmaceutical regulation: A proposal for principles to evaluate EU General Pharmaceutical Legislation from the innovator perspective by Heikkinen, Inkatuuli, Eskola, Sini, Acha, Virginia, Morrison, Alan, Walker, Chris, Weil, Catherine, Bril, Antoine, Wegner, Max, Metcalfe, Thomas, Chibout, Salah-Dine, Chlebus, Magda

“…•Pharmaceutical legislation is an important modulator of the pharmaceutical innovation system.•The legislation has evolved in the past 20 years into a complex…”
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Pimecrolimus Identifies a Common Genomic Anti-inflammatory Profile, is Clinically Highly Effective in Psoriasis and is Well Tolerated by Rappersberger, Klemens, Komar, Michael, Richter, Leo, Wolff, Klaus, Ebelin, Marie-Eve, Scott, Graham, Burtin, Pascale, Greig, Gerard, Kehren, Jeanne, Chibout, Salah-Dine, Cordier, Andre, Holter, Wolfgang, Oberbauer, Rainer, Stuetz, Anton

“…The ascomycin macrolactam pimecrolimus is a novel inflammatory cytokine release inhibitor that so far has not been administered systemically to humans. In this…”
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Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation by Schadt, Heiko S, Wolf, Armin, Mahl, Joerg Andreas, Wuersch, Kuno, Couttet, Philippe, Schwald, Marianne, Fischer, Audrey, Lienard, Mathilde, Emotte, Corinne, Teng, Chi-Hse, Skuba, Elizabeth, Richardson, Terrilyn A, Manenti, Luigi, Weiss, Andreas, Graus Porta, Diana, Fairhurst, Robin A, Kullak-Ublick, Gerd A, Chibout, Salah-Dine, Pognan, Francois, Kluwe, William, Kinyamu-Akunda, Jacqueline

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Bile acids in drug induced liver injury: Key players and surrogate markers by Schadt, Heiko S, Wolf, Armin, Pognan, Francois, Chibout, Salah-Dine, Merz, Michael, Kullak-Ublick, Gerd A

“…Summary Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered…”
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Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes by Richert, Lysiane, Lamboley, Christelle, Viollon-Abadie, Catherine, Grass, Peter, Hartmann, Nicole, Laurent, Stephane, Heyd, Bruno, Mantion, Georges, Chibout, Salah-Dine, Staedtler, Frank

“…The mRNA expression profile in control and clofibric acid (CLO)-treated mouse, rat, and human hepatocytes was analyzed using species-specific oligonucleotide…”
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A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function by Gerhold, David L, Ozer, Josef S, Dieterle, Frank, Troth, Sean, Perentes, Elias, Cordier, André, Verdes, Pablo, Staedtler, Frank, Mahl, Andreas, Grenet, Olivier, Roth, Daniel R, Wahl, Daniel, Legay, François, Holder, Daniel, Erdos, Zoltan, Vlasakova, Katerina, Jin, Hong, Yu, Yan, Muniappa, Nagaraja, Forest, Tom, Clouse, Holly K, Reynolds, Spencer, Bailey, Wendy J, Thudium, Douglas T, Topper, Michael J, Skopek, Thomas R, Sina, Joseph F, Glaab, Warren E, Vonderscher, Jacky, Maurer, Gérard, Chibout, Salah-Dine, Sistare, Frank D

“…A panel of urinary biomarkers enables the progression of renal injury and subsequent repair and recovery to be monitored after exposure of rats to either…”
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Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin by Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan, Uteng, Marianne

“…Arctigenin has previously been identified as a potential anti-tumor treatment for advanced pancreatic cancer. However, the mechanism of how arctigenin kills…”
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Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization by Segueni, Noria, Tritto, Elaine, Bourigault, Marie-Laure, Rose, Stéphanie, Erard, François, Le Bert, Marc, Jacobs, Muazzam, Di Padova, Franco, Stiehl, Daniel P., Moulin, Pierre, Brees, Dominique, Chibout, Salah-Dine, Ryffel, Bernhard, Kammüller, Michael, Quesniaux, Valerie F.

“…Antibodies targeting IL-17A or its receptor IL-17RA show unprecedented efficacy in the treatment of autoimmune diseases such as psoriasis. These therapies, by…”
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Safety differentiation: emerging competitive edge in drug development by Uteng, Marianne, Urban, Laszlo, Brees, Dominique, Muller, Patrick Y., Kullak-Ublick, Gerd A., Bouchard, Page, Tougas, Gervais, Chibout, Salah-Dine

“…•The key value-driver in pharma is break through therapies.•Safety is an important integral part of pharmaceutical differentiation.•Patient safety is much more…”
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LMX1B Mutations Cause Hereditary FSGS without Extrarenal Involvement by BOYER, Olivia, WOERNER, Stéphanie, SZUSTAKOWSKI, Joseph D, HEIBEL, Françoise, MATIGNON, Marie, BAUDOUIN, Véronique, CHANTREL, François, CHAMPIGNEULLE, Jacqueline, MARTIN, Laurent, NITSCHKE, Patrick, GUBLER, Marie-Claire, JOHNSON, Keith J, FAN YANG, CHIBOUT, Salah-Dine, ANTIGNAC, Corinne, OAKELEY, Edward J, LINGHU, Bolan, GRIBOUVAL, Olivier, TETE, Marie-Josèphe, DUCA, José S, KLICKSTEIN, Lloyd, DAMASK, Amy J

“…LMX1B encodes a homeodomain-containing transcription factor that is essential during development. Mutations in LMX1B cause nail-patella syndrome, characterized…”
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