Search Results - "Chibalina, M. V."

Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis by Puri, C, Chibalina, M V, Arden, S D, Kruppa, A J, Kendrick-Jones, J, Buss, F

“…Tissue expression microarrays, employed to determine the players and mechanisms leading to prostate cancer development, have consistently shown that myosin VI,…”
Get full text

Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder by Zhan, L., Kerr, J. R., Lafuente, M.-J., Maclean, A., Chibalina, M. V., Liu, B., Burke, B., Bevan, S., Nasir, J.

“…L. Zhan, J. R. Kerr, M.‐J. Lafuente, A. Maclean, M. V. Chibalina, B. Liu, B. Burke, S. Bevan and J. Nasir (2011) Neuropathology and Applied Neurobiology37,…”
Get full text

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion by Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik

“…Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers…”
Get full text

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production by Knudsen, Jakob G., Hamilton, Alexander, Ramracheya, Reshma, Tarasov, Andrei I., Brereton, Melissa, Haythorne, Elizabeth, Chibalina, Margarita V., Spégel, Peter, Mulder, Hindrik, Zhang, Quan, Ashcroft, Frances M., Adam, Julie, Rorsman, Patrik

“…Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice)…”
Get full text

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation by Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I, Cha, Chae Young, Chibalina, Margarita V, Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R, Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O, Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R V, Kaku, Kohei, Ladds, Graham, Rorsman, Patrik

“…Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated…”
Get full text

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets by Briant, Linford J.B., Dodd, Michael S., Chibalina, Margarita V., Rorsman, Nils J.G., Johnson, Paul R.V., Carmeliet, Peter, Rorsman, Patrik, Knudsen, Jakob G.

“…Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence,…”
Get full text

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion by Collins, Stephan C, Do, Hyun Woong, Hastoy, Benoit, Hugill, Alison, Adam, Julie, Chibalina, Margarita V, Galvanovskis, Juris, Godazgar, Mahdieh, Lee, Sheena, Goldsworthy, Michelle, Salehi, Albert, Tarasov, Andrei I, Rosengren, Anders H, Cox, Roger, Rorsman, Patrik

“…The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1…”
Get full text

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells by Hastoy, Benoît, Godazgar, Mahdieh, Clark, Anne, Nylander, Vibe, Spiliotis, Ioannis, van de Bunt, Martijn, Chibalina, Margarita V., Barrett, Amy, Burrows, Carla, Tarasov, Andrei I., Scharfmann, Raphael, Gloyn, Anna L., Rorsman, Patrik

“…Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used…”
Get full text

Na+ current properties in islet α‐ and β‐cells reflect cell‐specific Scn3a and Scn9a expression by Zhang, Quan, Chibalina, Margarita V., Bengtsson, Martin, Groschner, Lukas N., Ramracheya, Reshma, Rorsman, Nils J. G., Leiss, Veronika, Nassar, Mohammed A., Welling, Andrea, Gribble, Fiona M., Reimann, Frank, Hofmann, Franz, Wood, John N., Ashcroft, Frances M., Rorsman, Patrik

“…Key points α‐ and β‐cells express both Nav1.3 and Nav1.7 Na+ channels but in different relative amounts. The differential expression explains the different…”
Get full text

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton by Kudryashov, Dmitry S., Chibalina, Margarita V., Birukov, Konstantin G., Lukas, Thomas J., Sellers, James R., Van Eldik, Linda J., Watterson, D.Martin, Shirinsky, Vladimir P.

“…Myosin light chain kinase (MLCK) is the key regulator of cell motility and smooth muscle contraction in higher vertebrates. We searched for the features of the…”
Get full text

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes by Adam, Julie, Ramracheya, Reshma, Chibalina, Margarita V., Ternette, Nicola, Hamilton, Alexander, Tarasov, Andrei I., Zhang, Quan, Rebelato, Eduardo, Rorsman, Nils J.G., Martín-del-Río, Rafael, Lewis, Amy, Özkan, Gizem, Do, Hyun Woong, Spégel, Peter, Saitoh, Kaori, Kato, Keiko, Igarashi, Kaori, Kessler, Benedikt M., Pugh, Christopher W., Tamarit-Rodriguez, Jorge, Mulder, Hindrik, Clark, Anne, Frizzell, Norma, Soga, Tomoyoshi, Ashcroft, Frances M., Silver, Andrew, Pollard, Patrick J., Rorsman, Patrik

“…We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells…”
Get full text

Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder: Altered expression of dopamine signalling genes by Zhan, L., Kerr, J. R., Lafuente, M.-J., Maclean, A., Chibalina, M. V., Liu, B., Burke, B., Bevan, S., Nasir, J.

Get full text

Potential roles of myosin VI in cell motility by Chibalina, Margarita V, Puri, Claudia, Kendrick-Jones, John, Buss, Folma

“…There is now increasing evidence that myosin motor proteins, together with the dynamic actin filament machinery and associated adhesion proteins, play crucial…”
Get more information

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostellum by Zouwail, S, Pettitt, T R, Dove, S K, Chibalina, M V, Powner, D J, Haynes, L, Wakelam, MJO, Insall, R H

“…PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes,…”
Get full text

Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization by Birukov, Konstantin G., Schavocky, James P., Shirinsky, Vladimir P., Chibalina, Margarita V., Van Eldik, Linda J., Watterson, D. Martin

“…We report that the genetic locus that encodes vertebrate smooth muscle and nonmuscle myosin light chain kinase (MLCK) and kinase‐related protein (KRP) has a…”
Get full text

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium by Zouwail, Soha, Pettitt, Trevor R, Dove, Stephen K, Chibalina, Margarita V, Powner, Dale J, Haynes, Lee, Wakelam, Michael J O, Insall, Robert H

“…PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes,…”
Get full text

Evidence against the regulation of caldesmon inhibitory activity by p42/p44erk mitogen‐activated protein kinase in vitro and demonstration of another caldesmon kinase in intact gizzard smooth muscle by Krymsky, Mikhail A., Chibalina, Margarita V., Shirinsky, Vladimir P., Marston, Steven B., Vorotnikov, Alexander V.

“…The effect of direct phosphorylation by recombinant p44erk1 mitogen‐activated protein kinase on the inhibitory activity of caldesmon and its C‐terminal…”
Get full text

Functional properties and intracellular localization of high molecular weight isoforms of ligh chain myosin kinase by Chibalina, M V, Kudriashov, D S, Shekhonin, B V, Shirinskiĭ, V P

“…The vertebrate genetic locus, coding for a Ca2+/calmodulin-dependent enzyme myosin light chain kinase (MLCK), the key regulator of smooth muscle contraction…”
Get more information

Differences in phorbol-dependent phosphorylation of regulatory proteins and contraction of phasic and tonic smooth muscle by Vorotnikov, A V, Krymskiĭ, M A, Chibalina, M V, Kudriashov, D S, Shirinskiĭ, V P

“…Smooth muscles are divided into slowly contracting tonic and relatively fast phasic muscles. In both cases Ca2+ is a key mediator of the contractile response…”
Get more information