Search Results - "Chiba, P."

Classification of arm swing as a clinical marker of advancing spinal deformity among community-dwelling female volunteers 60 years or older by Kobayashi, Tetsuya, Jimbo, Shizuo, Senoo, Issei, Shimizu, Mutsuya, Ito, Hiroshi, Hisashi Chiba, P. T.

“…The clinical characteristics of adult spinal deformity (ASD) include worsening of deformity during gait, which leads to unstable posture and propensity to…”
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First results of a national external quality assessment scheme for the detection of SARS-CoV-2 genome sequences by Görzer, I., Buchta, Ch, Chiba, P., Benka, B., Camp, J.V., Holzmann, H., Puchhammer-Stöckl, E., Aberle, S.W.

“…•Implementation of SARS-CoV-2 genome testing by numerous laboratories in Austria.•Broad range of combinations of nucleic acid extraction and RT-PCR…”
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Pharmacoinformatic approaches to design natural product type ligands of ABC-transporters by Klepsch, F, Jabeen, I, Chiba, P, Ecker, G F

“…ABC-transporter have been recognized as being responsible for multiple drug resistance in tumor therapy, for decreased brain uptake and low oral…”
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O083 : Absence of BSEP/ABCB11 protects from cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis by Fuchs, C.D, Paumgartner, G, Wahlström, A, Chiba, P, Stojakovic, T, Claudel, T, Marschall, H.-U, Trauner, M

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Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24) by Heffeter, P., Jakupec, M.A., Körner, W., Chiba, P., Pirker, C., Dornetshuber, R., Elbling, L., Sutterlüty, H., Micksche, M., Keppler, B.K., Berger, W.

“…Recently, we have introduced [tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772, FFC24) as a new lanthanum compound which has promising anticancer…”
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Future directions for drug transporter modelling by Ekins, S., Ecker, G. F., Chiba, P., Swaan, P. W.

“…Since the late 1980s computational methods such as quantitative structure-activity relationship (QSAR) and pharmacophore approaches have become more widely…”
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Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A) by Heffeter, P, Pongratz, M, Steiner, E, Chiba, P, Jakupec, M A, Elbling, L, Marian, B, Körner, W, Sevelda, F, Micksche, M, Keppler, B K, Berger, W

“…KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A) is a metal complex with promising anticancer activity. Since chemoresistance is…”
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The importance of a nitrogen atom in modulators of multidrug resistance by Ecker, G, Huber, M, Schmid, D, Chiba, P

“…The presence of a nitrogen atom, charged at physiological pH, has frequently been considered to be a hallmark of P-glycoprotein (PGP) inhibitors, although…”
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Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance by Chiba, P, Ecker, G, Schmid, D, Drach, J, Tell, B, Goldenberg, S, Gekeler, V

“…The sodium channel blocker propafenone and a series of analogs have been identified as effective modulators of P-glyco-protein-mediated multidrug resistance in…”
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Structure–activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements by Schmid, Diethart, Ecker, Gerhard, Kopp, Stephan, Hitzler, Manuela, Chiba, Peter

“…Propafenone analogs (PAs) were previously identified as potent inhibitors of P-glycoprotein (Pgp)-mediated toxin efflux. For this as well as other classes of…”
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Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance by Kaiser, D, Smiesko, M, Kopp, S, Chiba, P, Ecker, G F

“…Overexpression of membrane bound, ATP-dependent transport proteins is one of the predominant mechanisms leading to multiple drug resistance in tumor therapy as…”
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Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein--an overview by Ecker, G, Chiba, P

“…Resistance of tumor cells to a wide variety of cytotoxic agents represents a major problem in cancer therapy. In most cases, the cross resistance profile has…”
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Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells by Yuan, Yueling, Cai, Tiange, Callaghan, Richard, Li, Qianwen, Huang, Yinghong, Wang, Bingyue, Huang, Qingqing, Du, Manling, Ma, Qianqian, Chiba, Peter, Cai, Yu

“…Psoralen (PSO), a major active component of Psoralea corylifolia, has been shown to overcome multidrug resistance in cancer. A drug carrier comprising a…”
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Flagging Drugs That Inhibit the Bile Salt Export Pump by Montanari, Floriane, Pinto, Marta, Khunweeraphong, Narakorn, Wlcek, Katrin, Sohail, M. Imran, Noeske, Tobias, Boyer, Scott, Chiba, Peter, Stieger, Bruno, Kuchler, Karl, Ecker, Gerhard F

“…The bile salt export pump (BSEP) is an ABC-transporter expressed at the canalicular membrane of hepatocytes. Its physiological role is to expel bile salts into…”
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Computational models for prediction of interactions with ABC-transporters by Ecker, Gerhard F., Stockner, Thomas, Chiba, Peter

“…The polyspecific ligand recognition pattern of ATB-binding cassette (ABC)-transporters, combined with the limited knowledge on the molecular basis of their…”
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Artificial neural networks as versatile tools for prediction of MDR-modulatory activity by Tmej, C, Chiba, P, Schaper, K J, Ecker, G, Fleischhacker, W

“…Following our ongoing studies on structure-activity relationship studies of propafenone-type modulators of multidrug resistance, we performed both a…”
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P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach by Pleban, Karin, Kopp, Stephan, Csaszar, Edina, Peer, Michael, Hrebicek, Thomas, Rizzi, Andreas, Ecker, Gerhard F, Chiba, Peter

“…P-glycoprotein (P-gp) is an energy-dependent multidrug efflux pump conferring resistance to cancer chemotherapy. Characterization of the mechanism of drug…”
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Investigation of cytotoxic effects of 8 norbornane derivatives on 4 human cancer cell lines using the MTT assay by Jäger, W, Päsler, B, Buchbauer, G, Chiba, P

“…A group of 8 structurally modified norbornane analogs, selected on basis of water solubility, was tested for its potential cytotoxic effects using a modified…”
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Self-Organizing Maps for Identification of New Inhibitors of P-Glycoprotein by Kaiser, Dominik, Terfloth, Lothar, Kopp, Stephan, Schulz, Jan, de Laet, Randolf, Chiba, Peter, Ecker, Gerhard F, Gasteiger, Johann

“…Self-organizing maps were trained to separate high- and low-active propafenone-type inhibitors of P-glycoprotein. The trained maps were subsequently used to…”
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P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir by JANNEH, Omar, ANWAR, Tariq, JUNGBAUER, Christof, KOPP, Stefan, KHOO, Saye H, BACK, David J, CHIBA, Peter

“…Drug efflux (for example, P-glycoprotein [P-gp], multidrug resistance-associated proteins [MRPs] and breast cancer resistance protein [BCRP]) and influx (for…”
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