Search Results - "Chiaro, Joseph A"

In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus by Smith, Lachlan J, Gorth, Deborah J, Showalter, Brent L, Chiaro, Joseph A, Beattie, Elizabeth E, Elliott, Dawn M, Mauck, Robert L, Chen, Weiliam, Malhotra, Neil R

“…Intervertebral disc degeneration is implicated as a major cause of low-back pain. There is a pressing need for new regenerative therapies for disc degeneration…”
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Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model by Martin, John T., Milby, Andrew H., Chiaro, Joseph A., Kim, Dong Hwa, Hebela, Nader M., Smith, Lachlan J., Elliott, Dawn M., Mauck, Robert L.

“…Intervertebral disc degeneration has been implicated in the etiology of low back pain; however, the current surgical strategies for treating symptomatic disc…”
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IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro by Gorth, Deborah J, Mauck, Robert L, Chiaro, Joseph A, Mohanraj, Bhavana, Hebela, Nader M, Dodge, George R, Elliott, Dawn M, Smith, Lachlan J

“…Inflammation plays a key role in the progression of intervertebral disc degeneration, a condition strongly implicated as a cause of lower back pain. The…”
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Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs by Chiaro, Joseph A, O'Donnell, Patricia, Shore, Eileen M, Malhotra, Neil R, Ponder, Katherine P, Haskins, Mark E, Smith, Lachlan J

“…ABSTRACT Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease characterized by deficient α‐L‐iduronidase activity, leading to the accumulation of…”
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Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture by Gorth, Deborah J, Lothstein, Katherine E, Chiaro, Joseph A, Farrell, Megan J, Dodge, George R, Elliott, Dawn M, Malhotra, Neil R, Mauck, Robert L, Smith, Lachlan J

“…ABSTRACT Degeneration of the intervertebral discs is strongly implicated as a cause of low back pain. Since current treatments for discogenic low back pain…”
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Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs by Chiaro, Joseph A, Baron, Matthew D, del Alcazar, Chelsea M, O'Donnell, Patricia, Shore, Eileen M, Elliott, Dawn M, Ponder, Katherine P, Haskins, Mark E, Smith, Lachlan J

“…Abstract Introduction Mucopolysaccharidosis I (MPS I) is a lysosomal storage disorder characterized by deficient α- l -iduronidase activity leading to…”
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Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture by Smith, Lachlan J, Chiaro, Joseph A, Nerurkar, Nandan L, Cortes, Daniel H, Horava, Sarena D, Hebela, Nader M, Mauck, Robert L, Dodge, George R, Elliott, Dawn M

“…Intervertebral disc degeneration is characterized by a cascade of cellular, biochemical and structural changes that may lead to functional impairment and low…”
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A comparative analysis of parvalbumin expression in pinfish ( Lagodon rhomboides) and toadfish ( Opsanus sp.) by Schoenman, Erich R., Chiaro, Joseph A., Jones, Ashley, Bastin, Loyd D., Coughlin, David J.

“…This study examines the role of a myoplasmic protein, parvalbumin, in enhancing muscle relaxation by fishes. Parvalbumin is thought to bind free Ca 2+ during…”
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Effects of neonatal enzyme replacement therapy and simvastatin treatment on cervical spine disease in mucopolysaccharidosis type I dogs by Smith, Lachlan J., Chiaro, Joseph A., O'Donnell, Patricia, Malhotra, Neil R., Shore, Eileen M., Ponder, Katherine P., Haskins, Mark E.

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IL-1ra delivered from poly microspheres attenuates IL-1[beta]-mediated degradation of nucleus pulposus in vitro by Gorth, Deborah J, Mauck, Robert L, Chiaro, Joseph A, Mohanraj, Bhavana, Hebela, Nader M, Dodge, George R, Elliott, Dawn M, Smith, Lachlan J

“…Introduction Inflammation plays a key role in the progression of intervertebral disc degeneration, a condition strongly implicated as a cause of lower back…”
Get full text