Search Results - "Chiarella, Renato A."

Polymorphism of Dehydro-Aripiprazole, the Active Metabolite of the Antipsychotic Drug Aripiprazole (Abilify) by Zeidan, Tarek A, Trotta, Jacob T, Chiarella, Renato A, Oliveira, Mark A, Hickey, Magali B, Almarsson, Örn, Remenar, Julius F

“…Crystal form exploration of dehydro-aripiprazole (dAPZ), the active metabolite of the antipsychotic drug aripiprazole (APZ), elucidated five polymorphs (I, II,…”
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The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms by Chiarella, Renato A, Gillon, Amy L, Burton, Rebecca C, Davey, Roger J, Sadiq, Ghazala, Auffret, Anthony, Cioffi, Marina, Hunter, Christopher A

“…This contribution concerns the issue of crystal nucleation in the polymorphic and hydrate forming system inosine-water. A combination of computational and…”
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Making Co-CrystalsThe Utility of Ternary Phase Diagrams by Chiarella, Renato A, Davey, Roger J, Peterson, Matthew L

“…We describe the use of ternary, isothermal phase diagrams of co-crystal-forming systems as a basis for understanding current crystallization methodologies and…”
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Structural Diversity of Brexpiprazole and Related Analogues: Impact on Solubility and Drug Delivery by Zeidan, Tarek A, Tilak, Pranoti A, Trotta, Jacob T, Curran, Erin, Oliveira, Mark A, Chiarella, Renato A, Almarsson, Örn, Hickey, Magali B

“…Brexpiprazole (BPZ) is an atypical antipsychotic drug indicated for the treatment of schizophrenia and depression. Crystal form screening of BPZ resulted in…”
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Applications of NIR in early stage formulation development. Part II. Content uniformity evaluation of low dose tablets by principal component analysis by Li, Weiyong, Bagnol, Laurent, Berman, Maxine, Chiarella, Renato A., Gerber, Michael

“…A near infrared method based on principal component analysis (PCA) was developed for predicting content uniformity of low dose tablets manufactured by a direct…”
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Making Co-CrystalsThe Utility of Ternary Phase Diagrams by Chiarella, Renato A., Davey, Roger J., Peterson, Matthew L.

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Particle-level insights into the powder flow behavior of the Fette 1200i tablet press feed frame using the discrete element method (DEM) by Kumar, Rohit, Li, Zihao, Guzman, Hector R., Chiarella, Renato A.

“…This study employs the DEM to simulate powder flow in the Fette-1200i tablet press three-chambered feed-frame system under varying operating conditions. It…”
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Influence of colloidal silicon dioxide‑magnesium stearate interaction on flow and compaction behavior of an MCC-Lactose binary mixture by Kumar, Rohit, Wagoner, Sam, Cummings, Jonathan, Tsolaki, Evangelia, Oliveira, Mark A., Worku, Zelalem A., Chiarella, Renato A.

“…The amount of glidant and lubricant in a tablet formulation is driven by their primary functionalities of enhancing flowability and reducing particle-wall…”
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Crystal Chemist, Crooner, Coach: A Transform Tribute to Professor Roger J. Davey by Almarsson, Örn, Collier, Sherry, Peterson, Matthew L., Hickey, Magali B., Cheung, Eugene Y., Oliveira, Mark, Chiarella, Renato A., Collier, Edwin A.

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Aripiprazole and Dehydro-Aripiprazole Solid Solutions: Crystalline Combinations of Drug and Active Metabolite in Tailored Compositions by Trotta, Jacob T., Zeidan, Tarek A., Tilak, Pranoti A., Foxman, Bruce M., Almarsson, Örn, Oliveira, Mark A., Chiarella, Renato A., Hickey, Magali B., Remenar, Julius F.

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Investigations into the role of the water activity for the control of solid form during crystallisation procedures by Chiarella, Renato A

“…In the pharmaceutical industry it is important to control the crystal phase and understand the solid state behaviour of the drug substance at an early stage of…”
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