Search Results - "Chiaramonte, Monica G."

The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis by Niese, Kathryn A, Chiaramonte, Monica G, Ellies, Lesley G, Rothenberg, Marc E, Zimmermann, Nives

“…Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine,…”
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Cationic Amino Acid Transporter 2 Regulates Inflammatory Homeostasis in the Lung by Rothenberg, Marc E., Doepker, Matthew P., Lewkowich, Ian P., Chiaramonte, Monica G., Stringer, Keith F., Finkelman, Fred D., MacLeod, Carol L., Ellies, Lesley G., Zimmermann, Nives

“…Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse…”
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Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response by Chiaramonte, Monica G, Mentink-Kane, Margaret, Jacobson, Bruce A, Cheever, Allen W, Whitters, Matthew J, Goad, Mary E P, Wong, Anthony, Collins, Mary, Donaldson, Debra D, Grusby, Michael J, Wynn, Thomas A

“…Highly polarized type 2 cytokine responses can be harmful and even lethal to the host if they are too vigorous or persist too long. Therefore, it is important…”
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Opposing Regulatory Roles of Complement Factor 5 in the Development of Bleomycin-Induced Pulmonary Fibrosis by Addis-Lieser, Erin, Kohl, Jorg, Chiaramonte, Monica G

“…The mechanisms of idiopathic pulmonary fibrosis pathogenesis, a chronic and progressive interstitial lung disease, remain elusive. The complement system, a…”
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Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis by Chiaramonte, Monica G., Cheever, Allen W., Malley, James D., Donaldson, Debra D., Wynn, Thomas A.

“…In several allergic, autoimmune, and infectious diseases, fibrosis is a major cause of morbidity and mortality. Here, using a model of infection-induced liver…”
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Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases by Vaillant, Brian, Chiaramonte, Monica G, Cheever, Allen W, Soloway, Paul D, Wynn, Thomas A

“…Hepatic fibrosis is the hallmark of Schistosoma mansoni infection and often results in portal hypertension and bleeding from esophageal varices. The fibrotic…”
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IL-13 Is a Key Regulatory Cytokine for Th2 Cell-Mediated Pulmonary Granuloma Formation and IgE Responses Induced by Schistosoma mansoni Eggs by Chiaramonte, Monica G, Schopf, Lisa R, Neben, Tamlyn Y, Cheever, Allen W, Donaldson, Debra D, Wynn, Thomas A

“…Schistosoma mansoni egg-induced pulmonary granuloma formation is a cell-mediated inflammatory response associated with dominant Th2-type cytokine expression,…”
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CpG Oligonucleotides Can Prophylactically Immunize Against Th2-Mediated Schistosome Egg-Induced Pathology by an IL-12-Independent Mechanism by Chiaramonte, Monica G, Hesse, Matthias, Cheever, Allen W, Wynn, Thomas A

“…Using a Schistosoma mansoni egg-induced granuloma model, we examined the ability of CpG oligodeoxynucleotides (ODN) to suppress Th2-type cytokine expression…”
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P‐selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon γ and the IL‐13 decoy receptor by Wynn, Thomas A., Hesse, Matthias, Sandler, Netanya G., Kaviratne, Mallika, Hoffmann, Karl F., Chiaramonte, Monica G., Reiman, Rachael, Cheever, Allen W., Sypek, Joseph P., Mentink‐Kane, Margaret M.

“…The selectin family of cell adhesion molecules is widely thought to promote inflammatory reactions by facilitating leukocyte recruitment. However, it was…”
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Expression of a Recombinant Fab Antibody Fragment against Cruzipain, the Major Cysteine Proteinase ofTrypanosoma cruzi by Kaplan, Dan, Baldi, Carolina, Chiaramonte, Mónica G., Fernandez, Marisa M., Levin, Mariano J., Malchiodi, Emilio, Baldi, Alberto

“…Cruzipain, the major proteinase ofTrypanosoma cruzi,plays an important role in the biology of this parasite. This study reports the development of a…”
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An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response by Chiaramonte, M G, Donaldson, D D, Cheever, A W, Wynn, T A

“…In schistosomiasis, chronic parasite egg-induced granuloma formation can lead to tissue destruction and fibrosis, which causes much of the morbidity and…”
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Expression of a recombinant Fab antibody fragment against cruzipain, the major cysteine proteinase of Trypanosoma cruzi by Kaplan, D, Baldi, C, Chiaramonte, M G, Fernandez, M M, Levin, M J, Malchiodi, E, Baldi, A

“…Cruzipain, the major proteinase of Trypanosoma cruzi, plays an important role in the biology of this parasite. This study reports the development of a…”
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Modulation of cardiac physiology by an anti-Trypanosoma cruzi monoclonal antibody after interaction with myocardium by Cremaschi, G, Zwirner, N W, Gorelik, G, Malchiodi, E L, Chiaramonte, M G, Fossati, C A, Sterin-Borda, L

“…Circulating antibodies from human and murine chagasic sera are able to interact with myocardium, activating neurotransmitter receptors. Here, we studied the…”
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